| SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion. | SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion.
Kim H, Choi IA, Umemoto A, Bae S, Kaneko K, Mizuno M, Giannopoulou E, Pannellini T, Deng L, Park-Min KH., Free PMC Article | 08/28/2024 |
| A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. | A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression.
Plebanek MP, Xue Y, Nguyen YV, DeVito NC, Wang X, Holtzhausen A, Beasley GM, Theivanthiran B, Hanks BA. | 06/17/2024 |
| Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome. | Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Chen Y, Liu Z, Chen H, Wen Y, Fan L, Luo M. | 05/29/2024 |
| Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3beta-Srebp2 axis. | Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis.
Toshima T, Yagi M, Do Y, Hirai H, Kunisaki Y, Kang D, Uchiumi T., Free PMC Article | 05/13/2024 |
| The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway. | The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway.
Huang Y, Wang YF, Ruan XZ, Lau CW, Wang L, Huang Y., Free PMC Article | 01/30/2024 |
| Enhanced SREBP2-driven cholesterol biosynthesis by PKClambda/iota deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. | Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J., Free PMC Article | 12/20/2023 |
| Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. | Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X., Free PMC Article | 09/6/2023 |
| Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. | Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.
Tang W, Thundyil J, Lim GGY, Tng TJW, Yeow SQZ, Nair A, Chai C, Yao TP, Lim KL., Free PMC Article | 04/27/2023 |
| Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis. | Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis.
Tang X, Qin Q, Xu W, Zhang X., Free PMC Article | 03/24/2023 |
| Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2. | Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2.
Chen W, Wen L, Bao Y, Tang Z, Zhao J, Zhang X, Wei T, Zhang J, Ma T, Zhang Q, Zhi X, Li J, Zhang C, Ni L, Li M, Liang T., Free PMC Article | 12/31/2022 |
| LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2NLRC4 Axis. | LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis.
Ma J, Chen J, Xue K, Yu C, Dang E, Qiao H, Fang H, Pang B, Li Q, Sun Z, Qiao P, Wang L, Wang G, Shao S. | 07/30/2022 |
| Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. | Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis.
Zhou X, Shin S, He C, Zhang Q, Rasband MN, Ren J, Dai C, Zorrilla-Veloz RI, Shingu T, Yuan L, Wang Y, Chen Y, Lan F, Hu J., Free PMC Article | 10/23/2021 |
| Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris. | Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.
Yang X, Lin P, Wang J, Liu N, Yin F, Shen N, Guo S. | 07/24/2021 |
| Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. | Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency.
Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J., Free PMC Article | 06/12/2021 |
| Data suggest that yes-associated protein (YAP) knockdown protects against hepatic steatosis through suppression of the interaction between YAP and sterol regulatory element binding proteins (SREBP-1c and SREBP-2). | A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice.
Shu Z, Gao Y, Zhang G, Zhou Y, Cao J, Wan D, Zhu X, Xiong W., Free PMC Article | 07/25/2020 |
| genetic ablation of SREBP activity in myeloid cells or topical pharmacological inhibition of SREBP improved skin wound healing under homeostatic and chronic inflammatory conditions | The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Kusnadi A, Park SH, Yuan R, Pannellini T, Giannopoulou E, Oliver D, Lu T, Park-Min KH, Ivashkiv LB., Free PMC Article | 12/14/2019 |
| MicroRNA-98 regulates hepatic cholesterol metabolism by targeting SREBP2 | MicroRNA-98 regulates hepatic cholesterol metabolism via targeting sterol regulatory element-binding protein 2.
Geng C, Dong T, Jin W, Yu B, Yin F, Peng F, Chen G, Ji C, Ding F. | 03/30/2019 |
| Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. | Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice.
Lee JH, Jia Y, Thach TT, Han Y, Kim B, Wu C, Kim Y, Seo WD, Lee SJ. | 05/12/2018 |
| increase in SREBP-2 directly activates expression of patatin-like phospholipase domain-containing enzyme 8 (PNPLA8) gene, and PNPLA8 associates with autophagosomes and is associated with a decrease in cellular triglyceride | SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy.
Kim KY, Jang HJ, Yang YR, Park KI, Seo J, Shin IW, Jeon TI, Ahn SC, Suh PG, Osborne TF, Seo YK., Free PMC Article | 04/28/2018 |
| Reexpression of SCAP in SCAP-deficient cells restored SREBP2 protein expression and partially restored steroidogenic responses, confirming the requirement of SCAP-SREBP2 in steroidogenesis. | SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.
Shimizu-Albergine M, Van Yserloo B, Golkowski MG, Ong SE, Beavo JA, Bornfeldt KE., Free PMC Article | 01/27/2018 |
| The deletion of Srebf-2 and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR activity and SREBP-1c expression. | Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.
Rong S, Cortés VA, Rashid S, Anderson NN, McDonald JG, Liang G, Moon YA, Hammer RE, Horton JD., Free PMC Article | 11/18/2017 |
| Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination. | Oligodendroglial myelination requires astrocyte-derived lipids.
Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG., Free PMC Article | 09/9/2017 |
| The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate. | Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, Chiba K. | 06/24/2017 |
| SIRT1 gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT signalling pathway, suggesting that SIRT1 gene may play a protective role against osteoarthritis. | Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice.
Yu F, Zeng H, Lei M, Xiao DM, Li W, Yuan H, Lin JJ. | 04/1/2017 |
| SREBP-2 is critical for survival and limb patterning during development | SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K., Free PMC Article | 12/17/2016 |