| Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. | Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction.
Yang W, Zhuang Y, Wu H, Su S, Li Y, Wang C, Tian Z, Peng L, Zhang X, Liu J, Pei X, Yuan W, Hu X, Meng B, Li D, Zhang Y, Shan H, Pan Z, Lu Y. | 10/28/2023 |
| Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome. | Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
Wang B, Dai Z, Gao Q, Liu Y, Gu G, Zheng H. | 03/19/2022 |
| CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage. | CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.
Zhu Y, Wen J, Huang G, Mittlesteadt J, Wen X, Lu X. | 05/15/2021 |
| Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer. | Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
Bernasocchi T, El Tekle G, Bolis M, Mutti A, Vallerga A, Brandt LP, Spriano F, Svinkina T, Zoma M, Ceserani V, Rinaldi A, Janouskova H, Bossi D, Cavalli M, Mosole S, Geiger R, Dong Z, Yang CG, Albino D, Rinaldi A, Schraml P, Linder S, Carbone GM, Alimonti A, Bertoni F, Moch H, Carr SA, Zwart W, Kruithof-de Julio M, Rubin MA, Udeshi ND, Theurillat JP., Free PMC Article | 03/6/2021 |
| SPOP is a key regulator of emergency hematopoiesis and inflammation sensing in the bone marrow. | The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation.
Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I., Free PMC Article | 11/23/2019 |
| SPOP is required for embryo implantation, endometrial decidualization, and uterine health in the mouse | Uterine function in the mouse requires speckle-type poz protein.
Hai L, Szwarc MM, He B, Lonard DM, Kommagani R, DeMayo FJ, Lydon JP., Free PMC Article | 07/27/2019 |
| no evidence that ERG is an effector of SPOP mutation in human prostate cancer or mouse models. | SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.
Shoag J, Liu D, Blattner M, Sboner A, Park K, Deonarine L, Robinson BD, Mosquera JM, Chen Y, Rubin MA, Barbieri CE., Free PMC Article | 05/11/2019 |
| loss of Spop, but not Spopl, disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh signaling and skeletal development | Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.
Cai H, Liu A., Free PMC Article | 04/14/2018 |
| Results demonstrate a negative role of Spop in the level and activity of Gli3, Shh signaling and ventral spinal cord patterning. | Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.
Cai H, Liu A., Free PMC Article | 12/23/2017 |
| Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation. | SPOP Regulates Endometrial Stromal Cell Decidualization in Mice.
Liu N, Liu X, Yu Q, Chen X, Ding Y, He J, Gao R, Wang Y, Liu X. | 09/30/2017 |
| These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability. | SPOP mutation leads to genomic instability in prostate cancer.
Boysen G, Barbieri CE, Prandi D, Blattner M, Chae SS, Dahija A, Nataraj S, Huang D, Marotz C, Xu L, Huang J, Lecca P, Chhangawala S, Liu D, Zhou P, Sboner A, de Bono JS, Demichelis F, Houvras Y, Rubin MA., Free PMC Article | 06/11/2016 |
| miR-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues. | Differential expression of speckled POZ protein, SPOP: putative regulation by miR-145.
Huang CJ, Chen HY, Lin WY, Choo KB. | 01/17/2015 |
| Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. | Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling.
Schwend T, Jin Z, Jiang K, Mitchell BJ, Jia J, Yang J., Free PMC Article | 01/25/2014 |
| similar S/T-rich motifs are present in Gli proteins as well as in numerous HIB-interacting proteins and mediate Gli degradation by SPOP | Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.
Zhang Q, Shi Q, Chen Y, Yue T, Li S, Wang B, Jiang J., Free PMC Article | 02/15/2010 |
| Interaction of endogenous PDX-1 and PCIF1 in MIN6 insulinoma cells, is demonstarted. | Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.
Liu A, Oliver-Krasinski J, Stoffers DA. | 01/21/2010 |
| MacroH2A1.2 binds the nuclear protein Spop. | MacroH2A1.2 binds the nuclear protein Spop.
Takahashi I, Kameoka Y, Hashimoto K. | 01/21/2010 |