| Runx3 Regulates CD8[+] T Cell Local Expansion and CD43 Glycosylation in Mice by H1N1 Influenza A Virus Infection. | Runx3 Regulates CD8(+) T Cell Local Expansion and CD43 Glycosylation in Mice by H1N1 Influenza A Virus Infection.
Hao Q, Kundu S, Shetty S, Tang H., Free PMC Article | 05/16/2024 |
| CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation. | CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
Bai J, Fan F, Gao C, Li S, Li W, Wei T, Cheng S, Yu J, Zheng C, Zhao J, Zou L, Feng L, Yi J, Qin H., Free PMC Article | 08/2/2023 |
| CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection. | CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection.
Alisson-Silva F, Mantuano NR, Lopes AL, Vasconcelos-Dos-Santos A, Vale AM, Costa MM, Cannon JL, Oliveira AC, Todeschini AR., Free PMC Article | 10/24/2020 |
| Data provide evidence for an important role of CD43 in modulating immune dysregulation and mortality following sepsis. | Increased mortality in CD43-deficient mice during sepsis.
Fay KT, Chihade DB, Chen CW, Klingensmith NJ, Lyons JD, Ramonell K, Liang Z, Coopersmith CM, Ford ML., Free PMC Article | 02/23/2019 |
| glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis | Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.
Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N., Free PMC Article | 08/13/2016 |
| findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1 | CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.
Velázquez F, Grodecki-Pena A, Knapp A, Salvador AM, Nevers T, Croce K, Alcaide P., Free PMC Article | 06/28/2016 |
| CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development. | Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report.
Meiler S, Baumer Y, McCurdy S, Lee BH, Kitamoto S, Boisvert WA., Free PMC Article | 03/28/2015 |
| We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production. | CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.
Zhou HF, Yan H, Cannon JL, Springer LE, Green JM, Pham CT., Free PMC Article | 07/6/2013 |
| Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism. | CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.
Cannon JL, Mody PD, Blaine KM, Chen EJ, Nelson AD, Sayles LJ, Moore TV, Clay BS, Dulin NO, Shilling RA, Burkhardt JK, Sperling AI., Free PMC Article | 12/10/2011 |
| study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage | Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
Hickey TB, Ziltener HJ, Speert DP, Stokes RW. | 04/30/2011 |
| The loss of both PSGL-1 and CD43 led to a further increase in T cell adhesion and proliferation | P-selectin glycoprotein ligand-1 negatively regulates T-cell immune responses.
Matsumoto M, Miyasaka M, Hirata T. | 01/21/2010 |
| The authors propose that CD43 is involved in the inflammatory response to M. tuberculosis and, through the induction of pro-inflammatory mediators, can regulate apoptosis to control intracellular growth of the bacterium. | CD43 controls the intracellular growth of Mycobacterium tuberculosis through the induction of TNF-alpha-mediated apoptosis.
Randhawa AK, Ziltener HJ, Stokes RW. | 01/21/2010 |
| CD43 generally serves as an antiadhesive molecule to attenuate neutrophil-endothelial interactions, but when E-selectin is expressed on endothelial cells, it also plays a proadhesive role as an E-selectin ligand. | CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner.
Matsumoto M, Shigeta A, Miyasaka M, Hirata T. | 01/21/2010 |
| results demonstrate that CD43 regulates Th cell differentiation in vitro and in vivo | CD43 regulates Th2 differentiation and inflammation.
Cannon JL, Collins A, Mody PD, Balachandran D, Henriksen KJ, Smith CE, Tong J, Clay BS, Miller SD, Sperling AI., Free PMC Article | 01/21/2010 |
| CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function | Signaling through CD43 regulates CD4 T-cell trafficking.
Mody PD, Cannon JL, Bandukwala HS, Blaine KM, Schilling AB, Swier K, Sperling AI., Free PMC Article | 01/21/2010 |
| Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. | Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice.
Fuzii HT, Travassos LR. | 01/21/2010 |
| CD43 is involved in the binding, uptake, and subsequent growth of Mycobacterium tuberculosis in murine macrophages and in vivo | CD43 is required for optimal growth inhibition of Mycobacterium tuberculosis in macrophages and in mice.
Randhawa AK, Ziltener HJ, Merzaban JS, Stokes RW. | 01/21/2010 |
| That CD43 costimulation was responsible for elevated cytokine/chemokine activity was confirmed at the transcriptional level by real-time PCR for IFN-gamma and CCL5, and by ELISA for IFN-gamma. | Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation.
Montufar-Solis D, Garza T, Klein JR., Free PMC Article | 01/21/2010 |
| Recruitment of neutrophils and activated T cells in in vivo models is not influenced by CD43 expression. | CD43 deficiency has no impact in competitive in vivo assays of neutrophil or activated T cell recruitment efficiency.
Carlow DA, Ziltener HJ. | 01/21/2010 |
| Cd43 displays dynamic roles in T cell immunity: a positive regulatory role in costimulation and trafficking of T cells to the central nervous system, and a negative regulatory role in the down-modulation of an immune response. | Dynamic regulation of T cell immunity by CD43.
Onami TM, Harrington LE, Williams MA, Galvan M, Larsen CP, Pearson TC, Manjunath N, Baum LG, Pearce BD, Ahmed R. | 01/21/2010 |
| Two functionally distinct populations of small intestinal intraepithelial lymphocytes (IELs) are described that differ according to the expression of a CD43 glycoform. | Maximum immunobioactivity of murine small intestinal intraepithelial lymphocytes resides in a subpopulation of CD43+ T cells.
Wang HC, Montufar-Solis D, Teng BB, Klein JR. | 01/21/2010 |
| These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells. | Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43.
Ford ML, Evavold BD. | 01/21/2010 |
| CD43 expressed on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in collaboration with PSGL-1. | CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin.
Matsumoto M, Shigeta A, Furukawa Y, Tanaka T, Miyasaka M, Hirata T. | 01/21/2010 |
| CD43 engagement and signaling are involved in the costimulatory and antiapoptotic effects of enzymatically inactive mutant trypanosomal trans-sialidase when it binds highly sialylated mucin CD43 on the T cell surface. | Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling.
Todeschini AR, Nunes MP, Pires RS, Lopes MF, Previato JO, Mendonça-Previato L, DosReis GA. | 01/21/2010 |
| Delayed onset of experimental autoimmune encephalomyelitis in CD43-deficient immunized mice and in recipients of adoptively transferred CD43-/- cells is characterized by significant reduction of T cell trafficking to the brain and spinal cord. | CD43 modulates severity and onset of experimental autoimmune encephalomyelitis.
Ford ML, Onami TM, Sperling AI, Ahmed R, Evavold BD. | 01/21/2010 |