| miR-495 promotes intestinal epithelial cell apoptosis through downregulation of Sphingosine-1-phosphate. | miR-495 promotes intestinal epithelial cell apoptosis through downregulation of Sphingosine-1-phosphate.
Li R, Cairns C, Yu TX, Jaladanki R, Dodson CM, Chung HK, Xiao L, Wang JY, Turner DJ., Free PMC Article | 09/12/2024 |
| SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway. | SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
Piao J, Su Z, He J, Zhu T, Fan F, Wang X, Yang Z, Zhan H, Luo D. | 08/1/2024 |
| Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis. | Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis.
Li S, Xue X, Zhang H, Jiang L, Zhang Y, Zhu X, Wang Y. | 02/22/2024 |
| Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. | Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y., Free PMC Article | 01/16/2024 |
| UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1. | UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1.
Epshtein Y, Mathew B, Chen W, Jacobson JR., Free PMC Article | 11/2/2023 |
| ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress. | ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress.
Chen H, Luo S, Chen H, Zhang C., Free PMC Article | 10/10/2023 |
| The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels. | The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.
Jiang ZJ, Gong LW., Free PMC Article | 06/12/2023 |
| miR-542-5p targets c-myc and negates the cell proliferation effect of SphK1 in intestinal epithelial cells. | miR-542-5p targets c-myc and negates the cell proliferation effect of SphK1 in intestinal epithelial cells.
Li R, Rao JN, Smith AD, Chung HK, Xiao L, Wang JY, Turner DJ., Free PMC Article | 02/27/2023 |
| Sphingosine Kinase-1 (SPHK1) promotes inflammation in infantile pneumonia by regulating NLRP3 inflammasome and SIRT1 expression. | Sphingosine Kinase-1 (SPHK1) promotes inflammation in infantile pneumonia by regulating NLRP3 inflammasome and SIRT1 expression.
Ding N, Meng Y, Liu L, Ma S, Chen Y. | 01/11/2023 |
| Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling. | Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
Chen J, Lockett A, Zhao S, Huang LS, Wang Y, Wu W, Tang M, Haider S, Velez Rendon D, Khan R, Liu B, Felesena N, Sysol JR, Valdez-Jasso D, Tang H, Bai Y, Natarajan V, Machado RF., Free PMC Article | 12/31/2022 |
| Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH. | Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH.
Montefusco D, Jamil M, Maczis MA, Schroeder W, Levi M, Ranjit S, Allegood J, Bandyopadhyay D, Retnam R, Spiegel S, Cowart LA., Free PMC Article | 07/16/2022 |
| Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells. | Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.
Hafizi R, Imeri F, Stepanovska Tanturovska B, Manaila R, Schwalm S, Trautmann S, Wenger RH, Pfeilschifter J, Huwiler A., Free PMC Article | 06/18/2022 |
| SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer. | SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer.
Wu JN, Lin L, Luo SB, Qiu XZ, Zhu LY, Chen D, Wei ED, Fu ZH, Qin MB, Liang ZH, Huang JA, Liu SQ., Free PMC Article | 03/5/2022 |
| Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer. | Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
Velazquez FN, Zhang L, Viscardi V, Trocchia C, Hannun YA, Obeid LM, Snider AJ., Free PMC Article | 10/23/2021 |
| Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease. | Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Anderson AK, Lambert JM, Montefusco DJ, Tran BN, Roddy P, Holland WL, Cowart LA., Free PMC Article | 10/23/2021 |
| Role of Sphingosine 1-Phosphate Signalling Axis in Muscle Atrophy Induced by TNFalpha in C2C12 Myotubes. | Role of Sphingosine 1-Phosphate Signalling Axis in Muscle Atrophy Induced by TNFα in C2C12 Myotubes.
Bernacchioni C, Ghini V, Squecco R, Idrizaj E, Garella R, Puliti E, Cencetti F, Bruni P, Donati C., Free PMC Article | 09/11/2021 |
| Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice. | Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice.
Lyu B, Wang W, Ji XY, Ritter JK, Li N., Free PMC Article | 09/11/2021 |
| Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice. | Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Matsumoto N, Yamashita T, Shang J, Feng T, Osakada Y, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K. | 09/11/2021 |
| Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFalpha-dependent inflammation and apoptosis. | Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFα-dependent inflammation and apoptosis.
Avni D, Harikumar KB, Sanyal AJ, Spiegel S., Free PMC Article | 07/17/2021 |
| Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene. | Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene.
Yao GQ, Zhu M, Walker J, Insogna K., Free PMC Article | 07/17/2021 |
| Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes. | Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes.
Jozefczuk E, Szczepaniak P, Guzik TJ, Siedlinski M., Free PMC Article | 05/15/2021 |
| Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-delta in sepsis-associated liver injury. | Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury.
Tian T, Yao D, Zheng L, Zhou Z, Duan Y, Liu B, Wang P, Li Y., Free PMC Article | 04/13/2021 |
| K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice. | K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Xie J, Shao Y, Liu J, Cui M, Xiao X, Gong J, Xue B, Zhang Q, Hu X, Duan H., Free PMC Article | 04/3/2021 |
| The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes. | The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Cheresh P, Kim SJ, Huang LS, Watanabe S, Joshi N, Williams KJN, Chi M, Lu Z, Harijith A, Yeldandi A, Lam AP, Gottardi C, Misharin AV, Budinger GRS, Natarajan V, Kamp DW., Free PMC Article | 02/20/2021 |
| Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells. | Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
Ranasinghe ADCU, Lee DD, Schwarz MA., Free PMC Article | 01/9/2021 |