| Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction. | Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
Chiang IK, Humphrey D, Mills RJ, Kaltzis P, Pachauri S, Graus M, Saha D, Wu Z, Young P, Sim CB, Davidson T, Hernandez-Garcia A, Shaw CA, Renwick A, Scott DA, Porrello ER, Wong ES, Hudson JE, Red-Horse K, Del Monte-Nieto G, Francois M., Free PMC Article | 10/11/2023 |
| SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2. | SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2.
Hernández-García A, Pendleton KE, Kim S, Li Y, Kim BJ, Zaveri HP, Jordan VK, Berry AM, Ljungberg MC, Chen R, Lanz RB, Scott DA., Free PMC Article | 06/23/2023 |
| The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. | The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner.
Chiang IKN, Graus MS, Kirschnick N, Davidson T, Luu W, Harwood R, Jiang K, Li B, Wong YY, Moustaqil M, Lesieur E, Skoczylas R, Kouskoff V, Kazenwadel J, Arriola-Martinez L, Sierecki E, Gambin Y, Alitalo K, Kiefer F, Harvey NL, Francois M., Free PMC Article | 03/4/2023 |
| Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice. | Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice.
Yang JM, Ryu J, Kim I, Chang H, Kim IK., Free PMC Article | 08/28/2021 |
| The first genome-wide analysis of Sox7 function. | Sox7 Regulates Lineage Decisions in Cardiovascular Progenitor Cells.
Doyle MJ, Magli A, Estharabadi N, Amundsen D, Mills LJ, Martin CM., Free PMC Article | 07/4/2020 |
| Sox7 mediates HLA I antibody-dependent endothelial cell activation and acute kidney allograft rejection via the Jagged1-Notch1 pathway. | Sox7 is involved in antibody-dependent endothelial cell activation and renal allograft injury via the Jagged1-Notch1 pathway.
Qin Y, Sun B, Zhang F, Wang Y, Shen B, Liu Y, Guo Y, Fan Y, Qiu J. | 05/23/2020 |
| Data show that SOX7, SOX17 and SOX18 (SOXF) transcriptional factors are induced during satellite cell specification. | SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity.
Alonso-Martin S, Auradé F, Mademtzoglou D, Rochat A, Zammit PS, Relaix F., Free PMC Article | 05/4/2019 |
| Sox7 promotes tumor growth via vessel abnormalization, and its level determines the therapeutic outcome of VEGFR2 inhibition in High-grade glioma. | Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.
Kim IK, Kim K, Lee E, Oh DS, Park CS, Park S, Yang JM, Kim JH, Kim HS, Shima DT, Kim JH, Hong SH, Cho YH, Kim YH, Park JB, Koh GY, Ju YS, Lee HK, Lee S, Kim I., Free PMC Article | 04/6/2019 |
| SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival. | SOX7 Is Required for Muscle Satellite Cell Development and Maintenance.
Rajgara RF, Lala-Tabbert N, Marchildon F, Lamarche É, MacDonald JK, Scott DA, Blais A, Skerjanc IS, Wiper-Bergeron N., Free PMC Article | 05/26/2018 |
| By E10.5, both Sox7 complete knockout and FLK1-specific deletion of Sox7 lead to widespread vascular defects. In contrast, while SOX7 is expressed in the earliest specified blood progenitors, the VAV-specific deletion of Sox7 does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development. | SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development.
Lilly AJ, Mazan A, Scott DA, Lacaud G, Kouskoff V., Free PMC Article | 04/7/2018 |
| Data provide evidence that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis with alterations of the haematopoietic system, inducing the proliferation of blood progenitors in the bone marrow while blocking B lymphopoiesis. | SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development.
Cuvertino S, Lacaud G, Kouskoff V., Free PMC Article | 11/25/2017 |
| SOX7 inhibits the expression of RUNX1 target genes in hemogenic endothelium, while having no effect on RUNX1 expression itself. SOX7 directly interacts with RUNX1 and inhibits its transcriptional activity. | Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac.
Lilly AJ, Costa G, Largeot A, Fadlullah MZ, Lie-A-Ling M, Lacaud G, Kouskoff V. | 09/16/2017 |
| Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation. | Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro JI, Osawa T, Aburatani H, Kodama T, Wada Y, Yamashita JK, Minami T., Free PMC Article | 09/16/2017 |
| combined deletion of Sox7, Sox17, and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity | Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
Zhou Y, Williams J, Smallwood PM, Nathans J., Free PMC Article | 07/16/2016 |
| These data indicate that Sox7 is dispensable for both differentiation and maturation of primitive endoderm in an mouse embryonic stem cell model system. | Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells.
Kinoshita M, Shimosato D, Yamane M, Niwa H., Free PMC Article | 01/16/2016 |
| ETV2 directly regulates Sox7, and ETV2 governs endothelial development by regulating transcriptional networks which include Sox7. | Sox7 is regulated by ETV2 during cardiovascular development.
Behrens AN, Zierold C, Shi X, Ren Y, Koyano-Nakagawa N, Garry DJ, Martin CM., Free PMC Article | 04/25/2015 |
| Notch and SoxF factors combinatorially regulate Dll4 expression in arteries downstream of VEGF. | Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.
Sacilotto N, Monteiro R, Fritzsche M, Becker PW, Sanchez-Del-Campo L, Liu K, Pinheiro P, Ratnayaka I, Davies B, Goding CR, Patient R, Bou-Gharios G, De Val S., Free PMC Article | 09/28/2013 |
| Haploinsufficiency of Sox7 or Gata4 is sufficient to produce anterior congenital diaphragmatic hernia in mice. | Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1.
Wat MJ, Beck TF, Hernández-García A, Yu Z, Veenma D, Garcia M, Holder AM, Wat JJ, Chen Y, Mohila CA, Lally KP, Dickinson M, Tibboel D, de Klein A, Lee B, Scott DA., Free PMC Article | 01/26/2013 |
| Disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes. | Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.
Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, Ghafoor S, Young NJ, Okamatsu Y, McGrath J, Koopman P, Sharpe PT, Ohazama A., Free PMC Article | 01/26/2013 |
| SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. | SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.
Costa G, Mazan A, Gandillet A, Pearson S, Lacaud G, Kouskoff V. | 06/2/2012 |
| Sox7-sustained expression in the earliest committed hematopoietic precursors promotes the maintenance of their multipotent and self-renewing status. | Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification.
Gandillet A, Serrano AG, Pearson S, Lie-A-Ling M, Lacaud G, Kouskoff V. | 01/21/2010 |
| SOX7 and SOX17 are not normally expressed during lymphatic development, excluding a conventional redundancy mechanism with SOX18. Instead, these genes are activated specifically in the absence of SOX18 function, and only in certain strains. | Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice.
Hosking B, François M, Wilhelm D, Orsenigo F, Caprini A, Svingen T, Tutt D, Davidson T, Browne C, Dejana E, Koopman P. | 01/21/2010 |
| differential Sox7 gene expression presents a novel biomarker profile, and possible regulatory switch, to distinguish cardiovascular pedigrees within Flk-1(+) multi-lineage progenitors | Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis.
Nelson TJ, Chiriac A, Faustino RS, Crespo-Diaz RJ, Behfar A, Terzic A., Free PMC Article | 01/21/2010 |
| both Sox7 and Sox15 are able to induce the early stages of myogenesis. | SOX15 and SOX7 differentially regulate the myogenic program in P19 cells.
Savage J, Conley AJ, Blais A, Skerjanc IS. | 01/21/2010 |
| is required for the induction of Gata-4 and Gata-6, and the interplay among these transcription factors plays a crucial role in parietal endoderm differentiation | Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression.
Futaki S, Hayashi Y, Emoto T, Weber CN, Sekiguchi K., Free PMC Article | 01/21/2010 |