| Ssc-MiR-21-5p and Ssc-MiR-615 Regulates the Proliferation and Apoptosis of Leydig Cells by Targeting SOX5. | Ssc-MiR-21-5p and Ssc-MiR-615 Regulates the Proliferation and Apoptosis of Leydig Cells by Targeting SOX5.
Tang Q, Zhang Y, Yue L, Ren H, Pan C., Free PMC Article | 08/6/2022 |
| Identification of a novel Sox5 transcript in mouse testis. | Identification of a novel Sox5 transcript in mouse testis.
Zheng B, Huang C, Zhou J, Ye L. | 01/22/2022 |
| High expression levels and localization of Sox5 in dilated cardiomyopathy. | High expression levels and localization of Sox5 in dilated cardiomyopathy.
Liu Y, Jiang B, Cao Y, Chen W, Yin L, Xu Y, Qiu Z., Free PMC Article | 04/13/2021 |
| SOX-5 activates a novel RORgammat enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation. | SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation.
Tian Y, Han C, Wei Z, Dong H, Shen X, Cui Y, Fu X, Tian Z, Wang S, Zhou J, Yang D, Sun Y, Yuan J, Ni B, Wu Y., Free PMC Article | 02/6/2021 |
| In conclusion, our current research is the first attempt to identify SOX5 as a regulator to promote MMP-9 expression and to potentiate the migration and invasion activity in rheumatoid arthritis-fibroblast-like synoviocytes. Our data highlight the relevance of SOX5 as a potential novel therapeutic target in RA. | Transcription Factor SOX5 Promotes the Migration and Invasion of Fibroblast-Like Synoviocytes in Part by Regulating MMP-9 Expression in Collagen-Induced Arthritis.
Shi Y, Wu Q, Xuan W, Feng X, Wang F, Tsao BP, Zhang M, Tan W., Free PMC Article | 06/15/2019 |
| Data show that SRY-box containing gene 5 protein (Sox5) can physically bind to the collapsin response mediator protein 5 (CRMP5) promoter DNA. | Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.
Naudet N, Moutal A, Vu HN, Chounlamountri N, Watrin C, Cavagna S, Malleval C, Benetollo C, Bardel C, Dronne MA, Honnorat J, Meissirel C, Besançon R., Free PMC Article | 11/3/2018 |
| the novel role of Tgfb2, Fbxl18, and Tle3 in formation of Sox5, Sox6, and Sox9 dependent tissues. | An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos.
Lee WJ, Chatterjee S, Yap SP, Lim SL, Xing X, Kraus P, Sun W, Hu X, Sivakamasundari V, Chan HY, Kolatkar PR, Prabhakar S, Lufkin T., Free PMC Article | 03/17/2018 |
| Low SOX5 expression is associated with Glioma. | SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells.
Kurtsdotter I, Topcic D, Karlén A, Singla B, Hagey DW, Bergsland M, Siesjö P, Nistér M, Carlson JW, Lefebvre V, Persson O, Holmberg J, Muhr J. | 11/4/2017 |
| Study revealed that Sox5 and Sox6 prevent oligodendroglial differentiation, thus ensuring that the progenitor cells first reach their proper destination and only then lose their migratory capacity | Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.
Baroti T, Zimmermann Y, Schillinger A, Liu L, Lommes P, Wegner M, Stolt CC. | 10/22/2016 |
| This study demonstrated that Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. | Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
Baroti T, Schillinger A, Wegner M, Stolt CC. | 08/6/2016 |
| Results show that Sox9, Sox5, and Sox13 transcription factors are expressed in postnatal testis and may regulate multiple functions such as steroidogenesis and spermatogenesis. | Expressions of Sox9, Sox5, and Sox13 transcription factors in mice testis during postnatal development.
Daigle M, Roumaud P, Martin LJ. | 06/4/2016 |
| Results suggest that L-Sox5 protein expression may diminish along with the progress of chondrogenic differentiation. L-Sox5 may act as a negative regulator if expressed aberrantly at least in part by regulating the critical fate of chondrogenesis. | Constitutive L-Sox5 overexpression delays differentiation of ATDC5 cells into chondrocytes and correlates with reduced expression of differentiation markers.
Sun D, Deepak V, Mu P, Jiang H, Shi X, Liu Z, Zeng X, Liu W. | 10/3/2015 |
| T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resistant to experimental autoimmune encephalomyelitis and delayed-type hypersensitivity. | Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H., Free PMC Article | 10/25/2014 |
| Sox5 regulates the proliferation of malignant B cells. | Expression and function of a novel isoform of Sox5 in malignant B cells.
Edwards SK, Desai A, Liu Y, Moore CR, Xie P., Free PMC Article | 04/26/2014 |
| L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity | L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.
Yamashita S, Miyaki S, Kato Y, Yokoyama S, Sato T, Barrionuevo F, Akiyama H, Scherer G, Takada S, Asahara H., Free PMC Article | 09/22/2012 |
| MiR-194 regulates chondrogenic differentiation of adipose-derived stem cells by targeting Sox5 | MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5.
Xu J, Kang Y, Liao WM, Yu L., Free PMC Article | 07/28/2012 |
| Genetic variation in the transcription factor SOX5 is associated with COPD susceptibility | SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development.
Hersh CP, Silverman EK, Gascon J, Bhattacharya S, Klanderman BJ, Litonjua AA, Lefebvre V, Sparrow D, Reilly JJ, Anderson WH, Lomas DA, Mariani TJ., Free PMC Article | 08/20/2011 |
| SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia. | Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5.
Kiselak EA, Shen X, Song J, Gude DR, Wang J, Brody SL, Strauss JF 3rd, Zhang Z., Free PMC Article | 10/30/2010 |
| These data suggest that synovial joint morphogenesis relies on essential roles for Sox5/6 in promoting both growth plate and articular chondrocyte differentiation. | Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage.
Dy P, Smits P, Silvester A, Penzo-Méndez A, Dumitriu B, Han Y, de la Motte CA, Kingsley DM, Lefebvre V., Free PMC Article | 05/31/2010 |
| Sox5 may suppress the oncogenic effects of PDGFB signaling during glioma development by regulating p27(Kip1) in a p19(Arf)-dependent manner, leading to acute cellular senescence. | Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence.
Tchougounova E, Jiang Y, Bråsäter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L. | 01/21/2010 |
| Expression of Sox-5 and BMP-2 were significantly upregulated in the fracture callus of myostatin-deficient (-/-) mice compared to wild-type (+/+) mice at two weeks following osteotomy. | Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume.
Kellum E, Starr H, Arounleut P, Immel D, Fulzele S, Wenger K, Hamrick MW., Free PMC Article | 01/21/2010 |
| Sox5 binds and recruits CtBP2 and HDAC1 to the regulatory regions of melanocytic Sox10 target genes and direct inhibition of Sox10-dependent promoter activation. | The transcription factor Sox5 modulates Sox10 function during melanocyte development.
Stolt CC, Lommes P, Hillgärtner S, Wegner M., Free PMC Article | 01/21/2010 |
| molecular identities of early-born subplate and deep-layer neurons are not acquired solely during generation or shortly thereafter but undergo progressive postmitotic refinement mediated by SOX5 | SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons.
Kwan KY, Lam MM, Krsnik Z, Kawasawa YI, Lefebvre V, Sestan N., Free PMC Article | 01/21/2010 |
| This study uncovers critical cis-acting elements and transcription factors driving Agc1 expression in cartilage and increases understanding of the mode of action of the chondrogenic Sox trio. | L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer.
Han Y, Lefebvre V., Free PMC Article | 01/21/2010 |
| Generation of mice harboring a Sox5 conditional null allele is reported. | Generation of mice harboring a Sox5 conditional null allele.
Dy P, Han Y, Lefebvre V. | 01/21/2010 |