| Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice. | Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Wang P, Kang Q, Wu WS, Rui L., Free PMC Article | 04/3/2024 |
| SNAI2 promotes the malignant transformation of oral leukoplakia by modulating p-EMT. | SNAI2 promotes the malignant transformation of oral leukoplakia by modulating p-EMT.
Shang Q, Peng J, Jiang Y, Qing M, Zhou Y, Xu H, Chen Q. | 12/15/2023 |
| Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis. | Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis.
Fu W, Gu H, Ye Y. | 11/30/2023 |
| Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter. | Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.
Santos VC, Ostler JB, Harrison KS, Jones C., Free PMC Article | 05/17/2023 |
| LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice. | LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.
Kim MH, Li Y, Zheng Q, Jiang L, Myers MG Jr, Wu WS, Rui L., Free PMC Article | 03/3/2023 |
| Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug. | Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
Liang X, Yan Z, Wang P, Liu Y, Ao X, Liu Z, Wang D, Liu X, Zhu M, Gao S, Xie D, Zhou P, Gu Y., Free PMC Article | 01/15/2022 |
| Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2. | Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2.
Yu L, Wu S, Che S, Wu Y, Han N. | 08/7/2021 |
| Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. | Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes.
Liu Y, Lin H, Jiang L, Shang Q, Yin L, Lin JD, Wu WS, Rui L., Free PMC Article | 02/6/2021 |
| Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. | Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Wei Q, Nakahara F, Asada N, Zhang D, Gao X, Xu C, Alfieri A, Brodin NP, Zimmerman SE, Mar JC, Guha C, Guo W, Frenette PS., Free PMC Article | 01/2/2021 |
| Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. | Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis.
Hultgren NW, Fang JS, Ziegler ME, Ramirez RN, Phan DTT, Hatch MMS, Welch-Reardon KM, Paniagua AE, Kim LS, Shon NN, Williams DS, Mortazavi A, Hughes CCW., Free PMC Article | 11/21/2020 |
| Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. | Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium.
Gross KM, Zhou W, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C. | 10/3/2020 |
| SNAI2 maintains progenitor-like features in neuroblastoma cells. | The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy.
Vrenken KS, Vervoort BMT, van Ingen Schenau DS, Derks YHW, van Emst L, Grytsenko PG, Middelbeek JAJ, van Leeuwen FN. | 08/12/2020 |
| Genetic or pharmacological inhibition of SLUG or forced expression of Slc13a3 suppresses the growth of human AML cells. | Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.
Zhang Z, Li L, Wu C, Yin G, Zhu P, Zhou Y, Hong Y, Ni H, Qian Z, Wu WS., Free PMC Article | 08/12/2020 |
| MiR-30a-3p is down-regulated in the embryo implantation period and might have some effect on embryo implantation by acting as a suppressor of Epithelial-mesenchymal transition through targeting Snai2. | MicroRNA-30a-3p regulates epithelial-mesenchymal transition to affect embryo implantation by targeting Snai2†.
Li L, Gou J, Yi T, Li Z. | 06/13/2020 |
| Circulating tumor cells demonstrate enhanced migration in part through fibronectin regulation of integrin B1 and SLUG. | Fibronectin Regulation of Integrin B1 and SLUG in Circulating Tumor Cells.
Huaman J, Naidoo M, Zang X, Ogunwobi OO., Free PMC Article | 12/21/2019 |
| Study report that the Slug is highly expressed in quiescent mouse satellite cell (SCs) and functions as a direct transcriptional repressor of p16Ink4a. Loss of Slug promotes de-repression of p16Ink4a in SCs and accelerates the entry of SCs into a fully senescent state upon damage-induced stress. p16Ink4a depletion partially rescues defects in Slug-deficient SCs. | The transcription factor Slug represses p16(Ink4a) and regulates murine muscle stem cell aging.
Zhu P, Zhang C, Gao Y, Wu F, Zhou Y, Wu WS., Free PMC Article | 07/6/2019 |
| Increased SNAI2 expression is associated with the development of severe pulmonary hypertension. | Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.
Tang H, Babicheva A, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX., Free PMC Article | 12/22/2018 |
| transgenic mice expressing Slug and Kras in acinar cells were generated. Surprisingly, Slug attenuated Kras-induced acinar-ductal metaplasia (ADM)development, ERK1/2 phosphorylation and proliferation. Co-expression of Slug with Kras also attenuated chronic pancreatitis-induced changes in ADM development and fibrosis | Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia.
Ebine K, Chow CR, DeCant BT, Hattaway HZ, Grippo PJ, Kumar K, Munshi HG., Free PMC Article | 05/19/2018 |
| Results indicate that vimentin orchestrates the healing by controlling fibroblast proliferation, TGF-beta1-Slug signaling, and epithelial-mesenchymal transition (EMT) processing, and all of which in turn govern the required keratinocyte activation. | Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β-Slug signaling.
Cheng F, Shen Y, Mohanasundaram P, Lindström M, Ivaska J, Ny T, Eriksson JE., Free PMC Article | 02/10/2018 |
| our current findings highlight how Slug functions as an important transcriptional repressor that finely regulates the SCF/c-Kit signaling pathway. | A novel slug-containing negative-feedback loop regulates SCF/c-Kit-mediated hematopoietic stem cell self-renewal.
Zhang Z, Zhu P, Zhou Y, Sheng Y, Hong Y, Xiang D, Qian Z, Mosenson J, Wu WS., Free PMC Article | 09/2/2017 |
| Slug emerges as a key transcription factor driving smooth muscle cell towards a proliferative phenotype. | Slug Is Increased in Vascular Remodeling and Induces a Smooth Muscle Cell Proliferative Phenotype.
Coll-Bonfill N, Peinado VI, Pisano MV, Párrizas M, Blanco I, Evers M, Engelmann JC, García-Lucio J, Tura-Ceide O, Meister G, Barberà JA, Musri MM., Free PMC Article | 08/5/2017 |
| both Snail and Slug are able to form binary complexes with either YAP or TAZ that, together, control YAP/TAZ transcriptional activity and function throughout mouse development. | Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation.
Tang Y, Weiss SJ., Free PMC Article | 06/24/2017 |
| results demonstrate that skeletal stem/stromal cell mobilize Snail/Slug-YAP/TAZ complexes to control stem cell function | Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation.
Tang Y, Feinberg T, Keller ET, Li XY, Weiss SJ., Free PMC Article | 06/10/2017 |
| The data presented here demonstrate that Snai2 and Snai3 transcriptionally regulate the cellular fitness and functionality of not only CD4(+) regulatory T cells but effector CD8(alpha+) and CD4(+) conventional T cells as well. | Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs.
Pioli PD, Whiteside SK, Weis JJ, Weis JH., Free PMC Article | 12/17/2016 |
| TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2. | IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion.
Ke CY, Xiao WL, Chen CM, Lo LJ, Wong FH., Free PMC Article | 08/6/2016 |