Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis.
Kang F, Xie L, Qin T, Miao Y, Kang Y, Takahashi T, Liang T, Xie H, Gaisano HY., Free PMC Article

STX2 drives colorectal cancer proliferation via upregulation of EXOSC4.
Wang YX, Li YZ, Zhu HF, Zhang ZY, Qian XL, He GY.

STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway.
Wang Y, Xu H, Jiao H, Wang S, Xiao Z, Zhao Y, Bi J, Wei W, Liu S, Qiu J, Li T, Liang L, Ye Y, Liao W, Ding Y., Free PMC Article

STX2 is a causative gene for nonobstructive azoospermia.
Nakamura S, Kobori Y, Ueda Y, Tanaka Y, Ishikawa H, Yoshida A, Katsumi M, Saito K, Nakamura A, Ogata T, Okada H, Nakai H, Miyado M, Fukami M.

Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2.
Xu R, Zhou J, Zhou XD, Li Q, Perelman JM, Kolosov VP.

Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-β-induced cell behaviors of human scar dermal fibroblasts.
Horigome T, Takumi S, Shirai K, Kido T, Hagiwara-Chatani N, Nakashima A, Adachi N, Yano H, Hirai Y.

HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells.
Shi L, Qin E, Zhou J, Zhao J, Nie W, Jiang T, Chen W, Wu D, Huang L, Liu L, Lv L, Zhao M, Zhang Z, Wang F., Free PMC Article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.
Huang J, Huffman JE, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA, Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, CARDIoGRAM Consortium, Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ, CHARGE Consortium Hemostatic Factor Working Group., Free PMC Article

Epimorphin-induced MET sensitizes ovarian cancer cells to platinum.
Yew KH, Crow J, Hirst J, Pessetto Z, Godwin AK., Free PMC Article

Extracellular epimorphin modulates epidermal differentiation signals mediated by epidermal growth factor receptor.
Okugawa Y, Hirai Y.

Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients.
van Loon JE, Sanders YV, de Wee EM, Kruip MJ, de Maat MP, Leebeek FW., Free PMC Article

Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis.
Jia YL, Shi L, Zhou JN, Fu CJ, Chen L, Yuan HF, Wang YF, Yan XL, Xu YC, Zeng Q, Yue W, Pei XT.

Effect of genetic variations in syntaxin-binding protein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk.
van Loon JE, Leebeek FW, Deckers JW, Dippel DW, Poldermans D, Strachan DP, Tang W, O'Donnell CJ, Smith NL, de Maat MP., Free PMC Article

Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.
Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC., Free PMC Article

Overexpression of extracellular epimorphin leads to impaired epidermal differentiation in HaCaT keratinocytes.
Okugawa Y, Hirai Y.

SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane.
Flaumenhaft R, Rozenvayn N, Feng D, Dvorak AM., Free PMC Article

Epimorphin expression in interstitial pneumonia.
Terasaki Y, Fukuda Y, Suga M, Ikeguchi N, Takeya M., Free PMC Article

Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3.
Kauppi M, Wohlfahrt G, Olkkonen VM.