| These results support a model in which the AE3 Cl(-)/HCO3(-) exchanger, coupled with parallel Cl(-) and H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-mediated disposal of CO2. | RNA SEQ Analysis Indicates that the AE3 Cl(-)/HCO(3)(-) Exchanger Contributes to Active Transport-Mediated CO(2) Disposal in Heart.
Vairamani K, Wang HS, Medvedovic M, Lorenz JN, Shull GE., Free PMC Article | 02/23/2019 |
| These findings suggest a new type of neuron-astrocyte communication, based on the expression of AE3 in neurons, which could explain how AE3 reduces seizure susceptibility | Role of Cl(-) -HCO(3)(-) exchanger AE3 in intracellular pH homeostasis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes.
Salameh AI, Hübner CA, Boron WF., Free PMC Article | 09/30/2017 |
| Ae3 is expressed in murine kidney at very low levels. | The murine Cl⁻/HCO⁻₃ exchanger Ae3 (Slc4a3) is not required for acid-base balance but is involved in magnesium handling by the kidney.
Kampik NB, Gehring N, Schnitzbauer U, Hennings JC, Hübner CA, Wagner CA. | 08/15/2015 |
| Report the importance of AE3-mediated Cl-/HCO3- exchange in cardiovascular pH regulation and the development of cardiomyocyte hypertrophy. | Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient in the AE3 Cl-/HCO3- exchanger.
Sowah D, Brown BF, Quon A, Alvarez BV, Casey JR., Free PMC Article | 01/24/2015 |
| In the TM180 cardiomyopathy model, loss of AE3 had no apparent anti-hypertrophic effect and led to more rapid decompensation and heart failure. | Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
Al Moamen NJ, Prasad V, Bodi I, Miller ML, Neiman ML, Lasko VM, Alper SL, Wieczorek DF, Lorenz JN, Shull GE., Free PMC Article | 05/14/2011 |
| Identification of Slc4a3 as underlying a previously unrecognized cause of blindness suggests this gene as a new candidate for a subset of hereditary vitreoretinal retinal degeneration | Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger.
Alvarez BV, Gilmour GS, Mema SC, Martin BT, Shull GE, Casey JR, Sauvé Y., Free PMC Article | 01/25/2010 |
| Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues. | Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction.
Casey JR, Sly WS, Shah GN, Alvarez BV., Free PMC Article | 01/21/2010 |
| It was concluded that the A867D allele is a functional mutant of AE3 and that the decreased activity of this mutation may cause changes in cell volume and abnormal intracellular pH. | Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3.
Vilas GL, Johnson DE, Freund P, Casey JR. | 01/21/2010 |
| In hippocampal neurons dissociated from anion exchanger AE3 knock-out mice, ammonium-induced alkalinization was much larger than that seen in neurons from wild-type mice. | Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.
Svichar N, Waheed A, Sly WS, Hennings JC, Hübner CA, Chesler M., Free PMC Article | 01/21/2010 |
| AE3 and NKCC1 affect Ca2+ handling | Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
Prasad V, Bodi I, Meyer JW, Wang Y, Ashraf M, Engle SJ, Doetschman T, Sisco K, Nieman ML, Miller ML, Lorenz JN, Shull GE., Free PMC Article | 01/21/2010 |
| Show that AE3 expression profoundly influences control of breathing in mice. | Expression of anion exchanger 3 influences respiratory rate in awake and isoflurane anesthetized mice.
Meier S, Hübner CA, Groeben H, Peters J, Bingmann D, Wiemann M. | 01/21/2010 |
| AE3 modulates seizure susceptibility in knockout mice. | Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Hentschke M, Wiemann M, Hentschke S, Kurth I, Hermans-Borgmeyer I, Seidenbecher T, Jentsch TJ, Gal A, Hübner CA., Free PMC Article | 01/21/2010 |