| Unraveling the molecular landscape of kAE1: a narrative review. | Unraveling the molecular landscape of kAE1: a narrative review.
Mungara P, Waiss M, Hartwig S, Burger D, Cordat E. | 07/11/2024 |
| Extracellular vesicle-derived miR-1249-5p regulates influenza A virus-induced acute lung injury in RAW246.7 cells through targeting SLC4A1. | Extracellular vesicle-derived miR-1249-5p regulates influenza A virus-induced acute lung injury in RAW246.7 cells through targeting SLC4A1.
Zhu M, Ma X, Huang J, Lu FG, Chen Y, Hu J, Cheng L, Zhang B, Liu W, Li L. | 11/19/2022 |
| protective factor in the pathogenesis of Meniere's disease | Solute carrier family 4 member 1 might participate in the pathogenesis of Meniere's disease in a murine endolymphatic hydrop model.
Sun S, Zhang D, Sun G, Song Y, Cai J, Fan Z, Wang H. | 03/7/2020 |
| properties are controlled by the O2-dependent association of hemoglobin with band 3 | Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties.
Chu H, McKenna MM, Krump NA, Zheng S, Mendelsohn L, Thein SL, Garrett LJ, Bodine DM, Low PS., Free PMC Article | 08/5/2017 |
| NH4Cl loading elicited adaptive doubling of AE1 mRNA in GPR4+/+, but a 50% less pronounced response in GPR4-/-. | Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.
Sun X, Stephens L, DuBose TD Jr, Petrovic S. | 10/3/2015 |
| Activities of AE1 and the sodium pump are coregulated in kidney. | Physical and functional links between anion exchanger-1 and sodium pump.
Su Y, Al-Lamki RS, Blake-Palmer KG, Best A, Golder ZJ, Zhou A, Karet Frankl FE., Free PMC Article | 04/25/2015 |
| AE1 is enhanced by acidosis, NaCl, and the combination of DOCA and NaHCO3 in renal collecting ducts. | Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone.
Mohebbi N, Perna A, van der Wijst J, Becker HM, Capasso G, Wagner CA., Free PMC Article | 07/27/2013 |
| These findings indicate that the conserved YXXPhi sequence or a noncanonical YXXXPhi sequence in the N-terminal region facilitates the endocytic recycling of erythroid AE1 through a clathrin-mediated pathway. | Clathrin-mediated endocytosis of mammalian erythroid AE1 anion exchanger facilitated by a YXXΦ or a noncanonical YXXXΦ motif in the N-terminal stretch.
Wang CC, Sato K, Otsuka Y, Otsu W, Inaba M. | 06/16/2012 |
| These results suggest that AE1 is potentially a key therapeutic target and the silencing of AE1 expression in gastric mucosa could provide a new therapeutic approach for treating gastric cancer. | Anti-tumour effects of small interfering RNA targeting anion exchanger 1 in experimental gastric cancer.
Suo WH, Zhang N, Wu PP, Zhao L, Song LJ, Shen WW, Zheng L, Tao J, Long XD, Fu GH., Free PMC Article | 06/9/2012 |
| These results demonstrate that mammalian erythroblast enucleation does not depend on the membrane integrity generated by the ankyrin-band 3 complex. | Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation.
Ji P, Lodish HF., Free PMC Article | 04/7/2012 |
| Data suggest that glycophorin A (Gpa) increases expression and activity of Cl-/HCO3- exchanger Ae1, that G719D mutation renders Ae1 mutant constructs GPA-unresponsive, and suggests a role for Ae1 amino acids 22-28 in GPA responsiveness. | Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1.
Stewart AK, Chebib FT, Akbar SW, Salas MJ, Sonik RA, Shmukler BE, Alper SL. | 07/23/2011 |
| podocyte protein kidney anion exchanger 1 interacts with nephrin and kinase to maintain the structure and function of the glomerular basement membrane. | Anion exchanger 1 interacts with nephrin in podocytes.
Wu F, Saleem MA, Kampik NB, Satchwell TJ, Williamson RC, Blattner SM, Ni L, Toth T, White G, Young MT, Parker MD, Alper SL, Wagner CA, Toye AM., Free PMC Article | 09/27/2010 |
| This review explores what is known about the erythrocyte membrane protein band 3 complexes of mice and humans, focussing on the observed species differences and their potential functional consequences. | Band 3 multiprotein complexes in the red cell membrane; of mice and men.
van den Akker E, Satchwell TJ, Williamson RC, Toye AM. | 09/13/2010 |
| Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC) spectrin deficiency, resulting in markedly reduced RBC membrane spectrin content, decreased band 3, and absent beta-adducin. | Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells.
Robledo RF, Lambert AJ, Birkenmeier CS, Cirlan MV, Cirlan AF, Campagna DR, Lux SE, Peters LL., Free PMC Article | 04/12/2010 |
| Suggest that the increase in Slc26a7 expression caused by deletion of AE1 represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney. | Increased acid load and deletion of AE1 increase Slc26a7 expression.
Sun X, Petrovic S. | 01/21/2010 |
| Study of the Ae1 E699Q mutation has revealed the existence of a novel pH-regulatory site of the Ae1 polypeptide. | Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity.
Chernova MN, Stewart AK, Barry PN, Jennings ML, Alper SL., Free PMC Article | 01/21/2010 |
| study shows that the DIDS-sensitive component of erythroid Cl(-) conductance is reduced or absent from Ae1(-/-) red cells; results are consistent with the hypothesis that the Ae1 anion exchanger polypeptide can operate infrequently in a conductive mode | Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes.
Alper SL, Vandorpe DH, Peters LL, Brugnara C., Free PMC Article | 01/21/2010 |
| the defect in self-tolerance in NZB AIHA is directed to the RBC type, and is not specific for, or dependent on, Band 3. Predisposition to RBC autoimmunity may be focused onto Band 3 by weak Th cell cross-reactivity | Deletion of the dominant autoantigen in NZB mice with autoimmune hemolytic anemia: effects on autoantibody and T-helper responses.
Hall AM, Ward FJ, Shen CR, Rowe C, Bowie L, Devine A, Urbaniak SJ, Elson CJ, Barker RN. | 01/21/2010 |
| Nucleotides encoding the 11-aa beta-hairpin loop in the mouse Slc4a1 gene replaced with sequence encoding a diglycine bridge thus destabilizing the eryhrocyte membrane. | An 11-amino acid beta-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes.
Stefanovic M, Markham NO, Parry EM, Garrett-Beal LJ, Cline AP, Gallagher PG, Low PS, Bodine DM., Free PMC Article | 01/21/2010 |
| The spectroscopic description of structural features of the P327R variant provides important clues about the location of one potential protein 4.2 binding surface on cytoplasmic domain of band 3 (cdb3) protein. | Structure of the cytoplasmic domain of erythrocyte band 3 hereditary spherocytosis variant P327R: band 3 Tuscaloosa.
Zhou Z, DeSensi SC, Stein RA, Brandon S, Song L, Cobb CE, Hustedt EJ, Beth AH. | 01/21/2010 |
| The slc4a1-/- mouse is the first genetic model of complete distal renal tubular acidosis. | Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1).
Stehberger PA, Shmukler BE, Stuart-Tilley AK, Peters LL, Alper SL, Wagner CA. | 01/21/2010 |
| two regions composed of helices 6, 7 and 8 and putative helices 12 and 13 which are required for anion conductance | Molecular mapping of the conductance activity linked to tAE1 expressed in Xenopus oocyte.
Borgese F, Renard C, Gabillat N, Pellissier B, Guizouarn H. | 01/21/2010 |
| Hematologic and survival data from C3H, CAST/Ei F2 wan homozygotes support the hypothesis that genetic modifiers significantly influence the band-3 null hereditary spherocytosis phenotype. | Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency.
Peters LL, Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA. | 01/21/2010 |
| data increase the minimal extent of a functionally defined carbonic anhydrase 2 binding site in anion exchanger 1 | Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer.
Dahl NK, Jiang L, Chernova MN, Stuart-Tilley AK, Shmukler BE, Alper SL. | 01/21/2010 |
| function as anion exchanger | [Band 3: expanding knowledge on its functions].
Inaba M. | 01/21/2010 |