| Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. | Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation.
Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B., Free PMC Article | 07/7/2023 |
| Intracellular beta1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. | Intracellular β(1)-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility.
Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK., Free PMC Article | 07/31/2021 |
| Study is the first to examine the subcellular localization of organic cation transporter 3 (OCT3) in any tissue, and the first to explore its spatial relationship to synaptic structures in the brain. Study suggests that OCT3 not only contributes to the clearance of extracellular monoamines, but also plays a role in their intracellular disposition and action. | Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice.
Gasser PJ, Hurley MM, Chan J, Pickel VM., Free PMC Article | 03/10/2018 |
| Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 in mice. | Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice.
Shirasaka Y, Lee N, Zha W, Wagner D, Wang J., Free PMC Article | 03/4/2017 |
| Study showed that few, if any, 5-HT neurons in the dorsal raphe are resistant to loss of Pet-1 for expression of Slc22a3 | Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons.
Wyler SC, Donovan LJ, Yeager M, Deneris E., Free PMC Article | 04/23/2016 |
| Findings suggest that OCT3 plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action. | Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM., Free PMC Article | 08/15/2015 |
| These results demonstrate that OCT3 is responsible for metformin accumulation and secretion in salivary glands. | Taste of a pill: organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands.
Lee N, Duan H, Hebert MF, Liang CJ, Rice KM, Wang J., Free PMC Article | 12/20/2014 |
| Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours. | Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Yang J, Kalogerou M, Gallacher J, Sampson JR, Shen MH. | 06/1/2013 |
| Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen. | Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channels.
Hollenhorst MI, Lips KS, Wolff M, Wess J, Gerbig S, Takats Z, Kummer W, Fronius M., Free PMC Article | 10/13/2012 |
| evidence for a new means of downregulating IL-4 production by basophils, both in vitro and in vivo, through OCT3 targeted by 5-HT and pharmacologic ligands. | Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands.
Schneider E, Machavoine F, Bricard-Rignault R, Levasseur M, Petit-Bertron AF, Gautron S, Ribeil JA, Launay JM, Mecheri S, Côté F, Dy M. | 11/19/2011 |
| these results show that reduced 5-HT clearance following HPA axis activation is likely mediated, at least in part, by the corticosterone-sensitive OCT3 | Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun.
Baganz N, Horton R, Martin K, Holmes A, Daws LC., Free PMC Article | 01/1/2011 |
| Slc22a3 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele. | The non-coding Air RNA is required for silencing autosomal imprinted genes.
Sleutels F, Zwart R, Barlow DP. | 12/9/2010 |
| a role of OCT3 in the regulation of fear and anxiety | Decreased anxiety in mice lacking the organic cation transporter 3.
Wultsch T, Grimberg G, Schmitt A, Painsipp E, Wetzstein H, Breitenkamp AF, Gründemann D, Schömig E, Lesch KP, Gerlach M, Reif A. | 01/21/2010 |
| Results suggest that organic cation transporter type 3 may be an important transporter mediating serotonergic signaling when serotonin transporter expression or function is compromised. | Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.
Baganz NL, Horton RE, Calderon AS, Owens WA, Munn JL, Watts LT, Koldzic-Zivanovic N, Jeske NA, Koek W, Toney GM, Daws LC., Free PMC Article | 01/21/2010 |
| findings show Air interacts with the Slc22a3 promoter chromatin & the H3K9 histone methyltransferase G9a in placenta; Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation & transcriptional repression | The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.
Nagano T, Mitchell JA, Sanz LA, Pauler FM, Ferguson-Smith AC, Feil R, Fraser P. | 01/21/2010 |
| OCT3 plays a role in the homeostatic regulation of aminergic neurotransmission in the brain. | Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice.
Vialou V, Balasse L, Callebert J, Launay JM, Giros B, Gautron S. | 01/21/2010 |
| STAT3 and Oct3/4, essential transcription factors for ES cell self-renewal, are involved in the regulation of Dax1 expression. | Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells.
Sun C, Nakatake Y, Ura H, Akagi T, Niwa H, Koide H, Yokota T. | 01/21/2010 |
| In 5HT transporter-deficient mice, OCT3 mRNA concentrations were significantly increased in the hippocampus, but not in other brain regions | Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice.
Schmitt A, Mössner R, Gossmann A, Fischer IG, Gorboulev V, Murphy DL, Koepsell H, Lesch KP. | 01/21/2010 |
| OCT3 is critical for the balanced neural and behavioral responses to environmentally induced variations in osmolarity and important for CNS function | Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation.
Vialou V, Amphoux A, Zwart R, Giros B, Gautron S., Free PMC Article | 01/21/2010 |
| Imprinted silencing of Slc22a3 does not need transcriptional overlap between Igf2r and Air. | Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air.
Sleutels F, Tjon G, Ludwig T, Barlow DP., Free PMC Article | 01/21/2010 |