| Analysis of biochemical features of ST8 alpha-N-acetyl-neuraminide alpha2,8-sialyltransferase (St8sia) 5 isoforms. | Analysis of biochemical features of ST8 α-N-acetyl-neuraminide α2,8-sialyltransferase (St8sia) 5 isoforms.
Araki E, Hane M, Hatanaka R, Kimura R, Tsuda K, Konishi M, Komura N, Ando H, Kitajima K, Sato C. | 04/16/2022 |
| Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression. | Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
Chen X, Wang L, Wu Y, Zhang H, Dong W, Yu X, Huang C, Li Y, Wang S, Zhang J. | 03/5/2022 |
| Knockdown of lncRNA MIR44352HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/betacatenin signaling pathway. | Knockdown of lncRNA MIR4435‑2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/β‑catenin signaling pathway.
Xing P, Wang Y, Zhang L, Ma C, Lu J., Free PMC Article | 11/22/2021 |
| Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia. | Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
Wang J, Zhang Q, Lu Y, Dong Y, Dhandapani KM, Brann DW, Yu RK., Free PMC Article | 11/22/2021 |
| GD3 synthase deletion alters retinal structure and impairs visual function in mice. | GD3 synthase deletion alters retinal structure and impairs visual function in mice.
Abreu CA, Teixeira-Pinheiro LC, Lani-Louzada R, da Silva-Junior AJ, Vasques JF, Gubert F, Nascimento-Dos-Santos G, Mohana-Borges R, Matos ES, Pimentel-Coelho PM, Santiago MF, Mendez-Otero R. | 11/22/2021 |
| Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model. | Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
Ohkawa Y, Zhang P, Momota H, Kato A, Hashimoto N, Ohmi Y, Bhuiyan RH, Farhana Y, Natsume A, Wakabayashi T, Furukawa K, Furukawa K., Free PMC Article | 09/18/2021 |
| Deletion of GD3 synthase attenuates bone loss that emerges with aging. | Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging.
Yo S, Hamamura K, Mishima Y, Hamajima K, Mori H, Furukawa K, Kondo H, Tanaka K, Sato T, Miyazawa K, Goto S, Togari A., Free PMC Article | 11/23/2019 |
| Targeted deletion of GD3S protects substantia nigra degeneration and prevents motor deficits associated with MPTP-poisoning. | Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.
Akkhawattanangkul Y, Maiti P, Xue Y, Aryal D, Wetsel WC, Hamilton D, Fowler SC, McDonald MP., Free PMC Article | 09/30/2017 |
| leptin/ObRb-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice | Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.
Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K. | 06/3/2017 |
| role of GD3 synthase in sciatic nerve and neuronal morphology during peripheral nerve regeneration | Mice lacking GD3 synthase display morphological abnormalities in the sciatic nerve and neuronal disturbances during peripheral nerve regeneration.
Ribeiro-Resende VT, Araújo Gomes T, de Lima S, Nascimento-Lima M, Bargas-Rega M, Santiago MF, Reis RA, de Mello FG., Free PMC Article | 06/27/2015 |
| This study demonistrated that Ganglioside deficiency(B4galnt1 and ST8SIA1 knockout mice causes inflammation and neurodegeneration via the activation of complement system in the spinal cord. | Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.
Ohmi Y, Ohkawa Y, Tajima O, Sugiura Y, Furukawa K, Furukawa K., Free PMC Article | 12/6/2014 |
| Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro. | Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro.
Wang J, Yu RK., Free PMC Article | 01/25/2014 |
| The results of this study indicated that destruction of glycolipid-enriched microdomain is caused by ganglioside deficiency with gradual intensity depending on the degree of defects of their compositions. | Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice.
Ohmi Y, Tajima O, Ohkawa Y, Yamauchi Y, Sugiura Y, Furukawa K, Furukawa K. | 04/2/2011 |
| This study showed that NMJs of old mice lacking GD3-synthase (expressing only O- and a-series gangliosides), which do not show an overt neurological phenotype but may develop subclinical synaptic deficits | Neuromuscular synaptic transmission in aged ganglioside-deficient mice.
Zitman FM, Todorov B, Verschuuren JJ, Jacobs BC, Furukawa K, Furukawa K, Willison HJ, Plomp JJ. | 03/19/2011 |
| GD3 has a role in hypoxia susceptibility by disabling the c-Src/NF-kappaB survival pathway resulting in lower Mn-SOD expression | GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.
Lluis JM, Llacuna L, von Montfort C, Bárcena C, Enrich C, Morales A, Fernandez-Checa JC., Free PMC Article | 05/3/2010 |
| The results of this study indicate that synaptic transmission at the NMJ is not crucially dependent on the particular presence of most ganglioside family members. | Neuromuscular synaptic function in mice lacking major subsets of gangliosides.
Zitman FM, Todorov B, Jacobs BC, Verschuuren JJ, Furukawa K, Furukawa K, Willison HJ, Plomp JJ. | 01/21/2010 |
| alpha2,8-sialyltransferase has roles in cell proliferation and mobility | Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility.
Kamimura Y, Furukawa K, Kittaka D, Nishio M, Hamamura K, Fukumoto S, Furukawa K. | 01/21/2010 |
| Molecular cloning and expression and sialylation of O-glycans | Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans.
Takashima S, Ishida HK, Inazu T, Ando T, Ishida H, Kiso M, Tsuji S, Tsujimoto M. | 01/21/2010 |