| Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. | Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
Sisario D, Spindler M, Ermer KJ, Grütz N, Nicolai L, Gaertner F, Machesky LM, Bender M., Free PMC Article | 02/28/2024 |
| CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders. | CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders.
Kim NS, Ringeling FR, Zhou Y, Nguyen HN, Temme SJ, Lin YT, Eacker S, Dawson VL, Dawson TM, Xiao B, Hsu KS, Canzar S, Li W, Worley P, Christian KM, Yoon KJ, Song H, Ming GL., Free PMC Article | 10/29/2022 |
| Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion. | Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.
Ma R, Pang K, Kang H, Zhang Y, Bang G, Park S, Hwang E, Ryu JR, Kwon Y, Kang HR, Jin C, Kim Y, Kim SY, Kwon SK, Kim D, Sun W, Kim JY, Han K. | 07/23/2022 |
| Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation. | Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation.
Shen W, Jin L, Zhu A, Lin Y, Pan G, Zhou S, Cheng J, Zhang J, Tu F, Liu C, Xie Q, Chen X. | 03/13/2021 |
| Persistent Cyfip1 Expression Is Required to Maintain the Adult Subventricular Zone Neurogenic Niche. | Persistent Cyfip1 Expression Is Required to Maintain the Adult Subventricular Zone Neurogenic Niche.
Habela CW, Yoon KJ, Kim NS, Taga A, Bell K, Bergles DE, Maragakis NJ, Ming GL, Song H., Free PMC Article | 09/5/2020 |
| CYFIP1 dosage can bi-directionally impact inhibitory synaptic structure and function. | Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT., Free PMC Article | 04/11/2020 |
| Cyfip1 haploinsufficiency, mimicking human 15q11.2 microdeletion syndrome, does not alter hippocampal phasic or tonic GABAergic inhibition, substantially differing from the Fmrp knock-out mouse model. | Cyfip1 Haploinsufficiency Does Not Alter GABA(A) Receptor δ-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV(+) Interneurons and Granule Cells.
Trent S, Hall J, Connelly WM, Errington AC., Free PMC Article | 04/4/2020 |
| Cyfip1 haploinsufficiency increased compulsive-like behavior and induced genetic background-dependent, sex-dependent, and parent-of-origin-dependent effects on food consumption and CYFIP1 expression. | Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.
Babbs RK, Beierle JA, Ruan QT, Kelliher JC, Chen MM, Feng AX, Kirkpatrick SL, Benitez FA, Rodriguez FA, Pierre JJ, Anandakumar J, Kumar V, Mulligan MK, Bryant CD., Free PMC Article | 02/15/2020 |
| Cyfip1 haploinsufficiency compromises brain connectivity and function, which might explain its genetic association to neuropsychiatric disorders. | The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.
Domínguez-Iturza N, Lo AC, Shah D, Armendáriz M, Vannelli A, Mercaldo V, Trusel M, Li KW, Gastaldo D, Santos AR, Callaerts-Vegh Z, D'Hooge R, Mameli M, Van der Linden A, Smit AB, Achsel T, Bagni C., Free PMC Article | 12/14/2019 |
| Cyfip1 haploinsufficiency in mice led to decreased dendritic spine density and stability associated with social behavior and motor learning phenotypes. Behavioral training early in development resulted in alleviating the motor learning deficits caused by Cyfip1 haploinsufficiency. | Behavioral training rescues motor deficits in Cyfip1 haploinsufficiency mouse model of autism spectrum disorders.
Bachmann SO, Sledziowska M, Cross E, Kalbassi S, Waldron S, Chen F, Ranson A, Baudouin SJ., Free PMC Article | 06/15/2019 |
| These results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction. | New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.
Abekhoukh S, Sahin HB, Grossi M, Zongaro S, Maurin T, Madrigal I, Kazue-Sugioka D, Raas-Rothschild A, Doulazmi M, Carrera P, Stachon A, Scherer S, Drula Do Nascimento MR, Trembleau A, Arroyo I, Szatmari P, Smith IM, Milà M, Smith AC, Giangrande A, Caillé I, Bardoni B., Free PMC Article | 12/9/2017 |
| In Cyfip1-deficient mice, parental origin determines the impairment of synaptic functions and behavior. | Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice.
Chung L, Wang X, Zhu L, Towers AJ, Cao X, Kim IH, Jiang YH., Free PMC Article | 09/24/2016 |
| Data suggest that MAP kinase-interacting kinases (Mnk1, Mnk2) regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of cytoplasmic eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1. | The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
Beggs JE, Tian S, Jones GG, Xie J, Iadevaia V, Jenei V, Thomas G, Proud CG. | 05/30/2015 |
| CYFIP2 is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior. | C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.
Kumar V, Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS., Free PMC Article | 01/11/2014 |
| This study demonistrated that CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation. | CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C., Free PMC Article | 11/16/2013 |
| haploinsufficiency of Cyfip1 mimics key aspects of the phenotype of Fmr1 knockout mice and are consistent with the hypothesis that these effects are mediated by interaction of Cyfip1 and Fmrp in regulating activity-dependent translation. | Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
Bozdagi O, Sakurai T, Dorr N, Pilorge M, Takahashi N, Buxbaum JD., Free PMC Article | 03/23/2013 |
| The translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1. | The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.
Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C. | 01/21/2010 |
| indentification on mouse chromosome 7C | Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
Chai JH, Locke DP, Greally JM, Knoll JH, Ohta T, Dunai J, Yavor A, Eichler EE, Nicholls RD., Free PMC Article | 01/21/2010 |
| Sra-1 and Nap1 are constitutive and essential components of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly. | Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.
Steffen A, Rottner K, Ehinger J, Innocenti M, Scita G, Wehland J, Stradal TE., Free PMC Article | 01/21/2010 |