| NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome. | NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome.
Sobh A, Encinas E, Patel A, Surapaneni G, Bonilla E, Kaestner C, Poullard J, Clerio M, Vasan K, Freeman T, Lv D, Dupéré-Richer D, Riva A, Barwick BG, Zhou D, Boise LH, Mitsiades CS, Kim B, Bennett RL, Chandel NS, Licht JD. | 08/5/2024 |
| Colorectal cancer-associated mutations impair EphB1 kinase function. | Colorectal cancer-associated mutations impair EphB1 kinase function.
Kim Y, Ahmed S, Miller WT., Free PMC Article | 11/2/2023 |
| Adenylate kinase 2 is a biomarker related to the prognosis of glioma and the immune microenvironment. | Adenylate kinase 2 is a biomarker related to the prognosis of glioma and the immune microenvironment.
Liu Z, Tang C, Teng X, Mohamed ZA, Fan J., Free PMC Article | 06/26/2023 |
| AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis. | AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.
Kim H, Jeong M, Na DH, Ryu SH, Jeong EI, Jung K, Kang J, Lee HJ, Sim T, Yu DY, Yu HC, Cho BH, Jung YK., Free PMC Article | 06/11/2022 |
| Adenylate kinase 2 expression and addiction in T-ALL. | Adenylate kinase 2 expression and addiction in T-ALL.
Maslah N, Latiri M, Asnafi V, Féroul M, Bedjaoui N, Steimlé T, Six E, Verhoyen E, Macintyre E, Lagresle-Peyrou C, Lhermitte L, Andrieu GP., Free PMC Article | 07/10/2021 |
| Reticular dysgenesis caused by an intronic pathogenic variant in AK2. | Reticular dysgenesis caused by an intronic pathogenic variant in AK2.
Ichikawa S, Prockop S, Cunningham-Rundles C, Sifers T, Conner BR, Wu S, Karam R, Walsh MF, Fiala E., Free PMC Article | 05/29/2021 |
| Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B-cell activation. | Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B-cell activation.
Chou J, Alazami AM, Jaber F, Hoyos-Bachiloglu R, Jones J, Weeks S, Alosaimi MF, Bainter W, Cangemi B, Badran YR, Mohammed R, Alroqi F, Almutairi A, Al-Onazi N, AlAjaji S, Al-Saud B, Arnaout R, Elkins M, Devana S, Imperial J, Li B, Drexhage L, Abdel Rahman AM, Jacob M, Haddad H, Hanna-Wakim R, Dbaibo G, Massaad MJ, Dasouki M, Mikhael R, Baz Z, Geha RS, Al-Mousa H. | 03/6/2021 |
| Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma. | Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
Liu H, Pu Y, Amina Q, Wang Q, Zhang M, Song J, Guo J, Mardan M., Free PMC Article | 11/21/2020 |
| Methylation on AK2 is associated with the development of anti-tuberculosis drug-induced liver injury. | Genome-Wide Analysis of DNA Methylation and Antituberculosis Drug-Induced Liver Injury in the Han Chinese Population.
Huai C, Wei Y, Li M, Zhang X, Wu H, Qiu X, Shen L, Chen L, Zhou W, Zhang N, Zhu G, Zhang Y, Zhang Z, He L, Qin S. | 06/6/2020 |
| Genetic variants of AK2 activates tenofovir for HIV therapy. | Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067.
Figueroa DB, Tillotson J, Li M, Piwowar-Manning E, Hendrix CW, Holtz TH, Bokoch K, Bekker LG, van Griensven F, Mannheimer S, Hughes JP, Grant RM, Bumpus NN., Free PMC Article | 08/4/2018 |
| Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression. | Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.
Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK. | 05/12/2018 |
| In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. | Lack of SIRPα phosphorylation and concomitantly reduced SHP-2-PI3K-Akt2 signaling decrease osteoblast differentiation.
Holm CK, Engman S, Sulniute R, Matozaki T, Oldenborg PA, Lundberg P. | 05/27/2017 |
| AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. | AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
Six E, Lagresle-Peyrou C, Susini S, De Chappedelaine C, Sigrist N, Sadek H, Chouteau M, Cagnard N, Fontenay M, Hermine O, Chomienne C, Reynier P, Fischer A, André-Schmutz I, Gueguen N, Cavazzana M., Free PMC Article | 04/16/2016 |
| results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. | The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth.
Kim H, Lee HJ, Oh Y, Choi SG, Hong SH, Kim HJ, Lee SY, Choi JW, Su Hwang D, Kim KS, Kim HJ, Zhang J, Youn HJ, Noh DY, Jung YK., Free PMC Article | 11/7/2015 |
| AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis. | Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.
Tanimura A, Horiguchi T, Miyoshi K, Hagita H, Noma T., Free PMC Article | 01/24/2015 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis. | Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.
Pannicke U, Hönig M, Hess I, Friesen C, Holzmann K, Rump EM, Barth TF, Rojewski MT, Schulz A, Boehm T, Friedrich W, Schwarz K. | 01/21/2010 |
| Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified. | Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.
Lagresle-Peyrou C, Six EM, Picard C, Rieux-Laucat F, Michel V, Ditadi A, Demerens-de Chappedelaine C, Morillon E, Valensi F, Simon-Stoos KL, Mullikin JC, Noroski LM, Besse C, Wulffraat NM, Ferster A, Abecasis MM, Calvo F, Petit C, Candotti F, Abel L, Fischer A, Cavazzana-Calvo M., Free PMC Article | 01/21/2010 |
| The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2 | Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
Topalis D, Alvarez K, Barral K, Munier-Lehmann H, Schneider B, Véron M, Guerreiro C, Mulard L, El-Amri C, Canard B, Deville-Bonne D. | 01/21/2010 |
| These results suggest that, acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis. | AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.
Lee HJ, Pyo JO, Oh Y, Kim HJ, Hong SH, Jeon YJ, Kim H, Cho DH, Woo HN, Song S, Nam JH, Kim HJ, Kim KS, Jung YK. | 01/21/2010 |