| Nuclear Sphingosine-1-phosphate Lyase Generated 2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. | Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells.
Ebenezer DL, Ramchandran R, Fu P, Mangio LA, Suryadevara V, Ha AW, Berdyshev E, Van Veldhoven PP, Kron SJ, Schumacher F, Kleuser B, Natarajan V., Free PMC Article | 07/26/2024 |
| Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis. | Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.
Afsar SY, Alam S, Fernandez Gonzalez C, van Echten-Deckert G., Free PMC Article | 10/29/2022 |
| Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice. | Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
De la Garza-Rodea AS, Moore SA, Zamora-Pineda J, Hoffman EP, Mistry K, Kumar A, Strober JB, Zhao P, Suh JH, Saba JD., Free PMC Article | 08/13/2022 |
| SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. | SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, Gentile D, Siddig S, Stork M, Hopkins CE, Händler K, Weis J, Roos A, Schultze JL, Nicotera P, Ehninger D, Bano D., Free PMC Article | 06/18/2022 |
| Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. | Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D., Free PMC Article | 11/13/2021 |
| Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development. | Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development.
Yuan F, Wang Z, Sun Y, Wei H, Cui Y, Wu Z, Zhang C, Xie KP, Wang F, Zhang M., Free PMC Article | 10/16/2021 |
| S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. | S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
Schwiebs A, Faqar-Uz-Zaman F, Herrero San Juan M, Radeke HH., Free PMC Article | 06/19/2021 |
| Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation. | Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation.
Alam S, Piazzesi A, Abd El Fatah M, Raucamp M, van Echten-Deckert G., Free PMC Article | 06/19/2021 |
| Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy. | Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.
Kageyama Y, Uranbileg B, Kusumoto Y, Sakai E, Ikeda H, Kurano M, Yatomi Y., Free PMC Article | 04/17/2021 |
| Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P2 receptor axis. | Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P(2) receptor axis.
Cencetti F, Bruno G, Bernacchioni C, Japtok L, Puliti E, Donati C, Bruni P. | 01/2/2021 |
| S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity. | S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.
Hagen-Euteneuer N, Alam S, Rindsfuesser H, Meyer Zu Heringdorf D, van Echten-Deckert G. | 12/26/2020 |
| Study identified S1P receptor 2 (S1PR2) as the mediator of both impaired autophagy and proinflammatory effects. The addition of exogenous S1P to BV2 microglial cells showed similar effects as those observed in the genetic knock out of SGPL1 in neural cells. Results show a novel role of the S1P-S1PR2 axis in the microglia of mice with neural-targeted SGPL1 ablation and in BV2 microglial cells exogenously treated with S1P. | Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation.
Karunakaran I, Alam S, Jayagopi S, Frohberger SJ, Hansen JN, Kuehlwein J, Hölbling BV, Schumak B, Hübner MP, Gräler MH, Halle A, van Echten-Deckert G. | 03/21/2020 |
| S1P is a potent osteoanabolic molecule, although S1P3 is not the sole receptor mediating this influence | Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase.
Heckt T, Brylka LJ, Neven M, Amling M, Schinke T., Free PMC Article | 03/14/2020 |
| Tissue SGPL1 knockout (T-SGPL(-/-)) provoked immediate occurrence of epithelial-driven tumors with upregulated sphingosine kinase 1, S1P receptor 2 and epidermal growth factor receptor. Here, progressing carcinogenesis was accompanied by an IL-12 to IL-23 shift with a consecutive development of a Th2/GATA3-driven, tumor-favoring microenvironment. | Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. | 12/14/2019 |
| High SGPL1 expression is associated with Huntington's disease. | Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V., Free PMC Article | 02/16/2019 |
| These results show that both a primary defect in cholesterol trafficking and S1P lyase deficiency cause overlapping phenotypic alterations, and challenge the present view on the role of sphingosine in lysosomal Ca(2+) homeostasis. | Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage.
Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, Meyer Zu Heringdorf D., Free PMC Article | 11/10/2018 |
| Partial genetic deletion of Sgpl1 protected mice against ventilator induced lung injury. | Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase.
Suryadevara V, Fu P, Ebenezer DL, Berdyshev E, Bronova IA, Huang LS, Harijith A, Natarajan V., Free PMC Article | 08/4/2018 |
| Study identifies sphingosine 1-phosphate metabolism as a novel player in modulating synaptic architecture and plasticity. | Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.
Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G., Free PMC Article | 05/19/2018 |
| SGPL1 modulates neuronal autophagy via phosphatidylethanolamine production | SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G., Free PMC Article | 03/31/2018 |
| Study verifies the role of a high-ranked gene in dysregulation of sphingolipid metabolism in the disease and demonstrate that inhibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's disease models. | Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.
Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E., Free PMC Article | 01/20/2018 |
| Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury, and the role in this process of S1P lyase has been described. (Review) | Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase.
Ebenezer DL, Fu P, Suryadevara V, Zhao Y, Natarajan V., Free PMC Article | 11/18/2017 |
| Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M, Hurcombe J, Bierzynska A, Barbagelata E, Bergadá I, Cassinelli H, Das U, Krone R, Hacihamdioglu B, Sari E, Yesilkaya E, Storr HL, Clemente M, Fernandez-Cancio M, Camats N, Ram N, Achermann JC, Van Veldhoven PP, Guasti L, Braslavsky D, Guran T, Metherell LA., Free PMC Article | 09/9/2017 |
| Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency | Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F., Free PMC Article | 09/9/2017 |
| deleting SPL in CD11c(+) dendritic cells (DCs), rather than thymic epithelial cells or other stromal cells, disrupts the sphingosine-1-phosphate gradient, preventing egress. | Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD., Free PMC Article | 08/12/2017 |
| The sphingosine-1-phosphate lyase contributes to the restriction of Legionella pneumophila in murine macrophages. | The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages.
Abu Khweek A, Kanneganti A, Guttridge D DC, Amer AO., Free PMC Article | 07/2/2016 |