| Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection. | Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection.
Scheffzük C, Biedziak D, Gisch N, Goldmann T, Stamme C. | 08/13/2024 |
| Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx. | Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.
Avcibas R, Vermul A, Gluhovic V, Boback N, Arroyo R, Kingma P, Isasi-Campillo M, Garcia-Ortega L, Griese M, Kuebler WM, Ochs M, Lauster D, Lopez-Rodriguez E., Free PMC Article | 05/7/2024 |
| Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation. | Disruption of the SP-A/SP-R210(L) (MYO18Aα) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation.
Guan Z, Worth B, Umstead TM, Amatya S, Booth J, Chroneos ZC., | 04/11/2024 |
| Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice. | Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.
Dare A, King SD, Chen SY., Free PMC Article | 04/3/2024 |
| Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain. | Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
Araujo AP, Oliveira MLS, Miyaji EN. | 12/6/2023 |
| Surfactant Protein A can Affect the Surface Tension of the Eustachian Tube and Macrophage Migration. | Surfactant Protein A can Affect the Surface Tension of the Eustachian Tube and Macrophage Migration.
Li G, Chen T, Mao Y, Ai Y, Yan W, Lu Y, Liu W, Wang H, Li L. | 06/14/2023 |
| Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries. | Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries.
Chen X, Guo J, Mahmoud S, Vanga G, Liu T, Xu W, Xiong Y, Xiong W, Abdel-Razek O, Wang G., Free PMC Article | 06/12/2023 |
| Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice. | Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice.
Crocker CE, Sharmeen R, Tran TT, Khan AM, Li W, Alcorn JL., Free PMC Article | 03/31/2023 |
| Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report. | Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
Ran R, Cai D, King SD, Que X, Bath JM, Chen SY., Free PMC Article | 06/5/2021 |
| Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice. | Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.
Phelps DS, Chinchilli VM, Weisz J, Yang L, Shearer D, Zhang X, Floros J., Free PMC Article | 05/29/2021 |
| SP-A mediated Haemophilus influenzae aggregation and killing and enhanced bacterial phagocytosis by macrophages in vitro and modulated inflammation of the middle ear in otitis media in vivo. | Innate immunity of surfactant protein A in experimental otitis media.
Abdel-Razek O, Ni L, Yang F, Wang G., Free PMC Article | 04/18/2020 |
| SP-A aids in the resolution of allergic airway inflammation by promoting eosinophil clearance from lung tissue through chemotaxis. | Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.
Dy ABC, Arif MZ, Addison KJ, Que LG, Boitano S, Kraft M, Ledford JG., Free PMC Article | 04/11/2020 |
| SP-A and SP-D in the kidneys were significantly higher in Acute kidney injury than in the sham. | Change of surfactant protein D and A after renal ischemia reperfusion injury.
Imtiazul IM, Asma R, Lee JH, Cho NJ, Park S, Song HY, Gil HW., Free PMC Article | 04/4/2020 |
| Loss of Sftpa1 do not result in retinal degeneration. | Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice.
Bhatti F, Kung JW, Vieira F., Free PMC Article | 01/5/2019 |
| SP-A deficiency exacerbates unilateral ureter obstruction -caused kidney structural damage and fibrosis in mice. | Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice.
Tian S, Li C, Ran R, Chen SY., Free PMC Article | 12/22/2018 |
| SP-A1 variants play an important role in the observed sex differences in airway hyperreactivity in response to infection and methacholine challenge and thus sex hormones may differentially affect lung function. | Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences.
Thorenoor N, Zhang X, Umstead TM, Scott Halstead E, Phelps DS, Floros J., Free PMC Article | 11/10/2018 |
| The data provide evidence SP-A and SP-D attenuate S. aureus pneumonia severity resulting in decreased intestinal mucosal injury, apoptosis, and inflammation. | Surfactant Proteins SP-A and SP-D Ameliorate Pneumonia Severity and Intestinal Injury in a Murine Model of Staphylococcus Aureus Pneumonia.
Du X, Meng Q, Sharif A, Abdel-Razek OA, Zhang L, Wang G, Cooney RN. | 02/3/2018 |
| In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A and SPC but not SPB and SPD expression. | Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM., Free PMC Article | 12/9/2017 |
| Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A, SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS challenge are clues relevant to suggest their involvement in testicular immune privilege. | Testicular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide.
Rokade S, Madan T. | 12/2/2017 |
| SP-A/D double knock-out mice showed increased susceptibility to urinary tract infection | Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli.
Hu F, Ding G, Zhang Z, Gatto LA, Hawgood S, Poulain FR, Cooney RN, Wang G., Free PMC Article | 10/1/2016 |
| Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy. | Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model.
Yadav AK, Chaudhari H, Shah PK, Madan T. | 09/24/2016 |
| The presence of SP-A and SP-D in the murine decidua is likely to play a protective role against intrauterine infection during pregnancy. | Expression of surfactant proteins SP-A and SP-D in murine decidua and immunomodulatory effects on decidual macrophages.
Madhukaran SP, Koippallil Gopalakrishnan AR, Pandit H, Marri ED, Kouser L, Jamil K, Alhamlan FS, Kishore U, Madan T. | 09/24/2016 |
| Data show that the type IV pilus (Tfp)-deficient mutant DeltapilA is severely attenuated in an acute pneumonia model of infection in the lungs of wild-type mice, but is virulent in the lungs of surfactant protein-A SP-A(-/-) mice. | Type IV pilus of Pseudomonas aeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-A.
Tan RM, Kuang Z, Hao Y, Lau GW., Free PMC Article | 11/21/2015 |
| SP-A and SP-D attenuate kidney injury by modulating inflammation and apoptosis in sepsis-induced AKI. | Role of surfactant proteins A and D in sepsis-induced acute kidney injury.
Liu J, Abdel-Razek O, Liu Z, Hu F, Zhou Q, Cooney RN, Wang G., Free PMC Article | 08/15/2015 |
| Maternal SP-A impacts milk sIgA and cytokine content, and is associated with improved newborn health. | Maternal surfactant protein A influences the immunoprotective properties of milk in a murine model.
Gidvani MP, Theisen E, Leduc R, George CL. | 04/4/2015 |