| Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase. | Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase.
Koda T, Namba A, Kinoshita M, Nakatsuji Y, Sugimoto T, Sakakibara K, Tada S, Shimizu M, Yamashita K, Takata K, Ishikura T, Murata S, Beppu S, Kumanogoh A, Mochizuki H, Okuno T., Free PMC Article | 12/12/2020 |
| We highlight a common but age-related Sema4a-mediated pathway by which plasmacytoid dendritic cells and microbial colonization induce T reg cell expansion to protect against severe bronchiolitis and subsequent asthma. | Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion.
Lynch JP, Werder RB, Loh Z, Sikder MAA, Curren B, Zhang V, Rogers MJ, Lane K, Simpson J, Mazzone SB, Spann K, Hayball J, Diener K, Everard ML, Blyth CC, Forstner C, Dennis PG, Murtaza N, Morrison M, Ó Cuív P, Zhang P, Haque A, Hill GR, Sly PD, Upham JW, Phipps S., Free PMC Article | 04/13/2019 |
| Sema4A functions through postsynaptic Plexin-B2 for excitatory synapse development. | Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus.
McDermott JE, Goldblatt D, Paradis S., Free PMC Article | 03/9/2019 |
| Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. | A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.
Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T., Free PMC Article | 06/3/2017 |
| SEMA4A is required for optimal activation of mTORC1 in CD8+ T cells. | mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.
Ito D, Nojima S, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A., Free PMC Article | 10/31/2015 |
| Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a-Nrp1 axis-- this pathway is a potential therapeutic target that could limit Treg-cell-mediated tumour-induced tolerance without inducing autoimmunity | Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.
Delgoffe GM, Woo SR, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J, Workman CJ, Vignali DA., Free PMC Article | 12/14/2013 |
| Data indicate that both semaphorin 4A mRNA and protein were clearly detected on the earliest progenitors and were downregulated through thymic development. | Semaphorin 4A is dynamically regulated during thymocyte development in mice.
Linder GE, Chuntova PD, McLelland BT, Añó L, Obodo UC, Crider NJ, Matthes DJ, García-Ojeda ME, Manilay JO, Chatterjea D. | 08/31/2013 |
| These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis. | A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration.
Nojima S, Toyofuku T, Kamao H, Ishigami C, Kaneko J, Okuno T, Takamatsu H, Ito D, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Ogata A, Ikawa M, Morii E, Aozasa K, Takagi J, Takahashi M, Kumanogoh A., Free PMC Article | 06/22/2013 |
| A fraction of Sema4a-deficient transgenic BALB/c mice spontaneously develop skin lesions resembling atopic dermatitis (AD) in humans. | An inhibitory role for Sema4A in antigen-specific allergic asthma.
Morihana T, Goya S, Mizui M, Yasui T, Prasad DV, Kumanogoh A, Tamura M, Shikina T, Maeda Y, Iwamoto Y, Inohara H, Kikutani H. | 04/27/2013 |
| These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology. | Neuroimmune semaphorin 4A downregulates the severity of allergic response.
Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, Kikutani H, Keegan AD, Chapoval SP., Free PMC Article | 10/20/2012 |
| Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis and participates in their recruitment and activation in inflammatory injuries. | Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
Meda C, Molla F, De Pizzol M, Regano D, Maione F, Capano S, Locati M, Mantovani A, Latini R, Bussolino F, Giraudo E. | 06/23/2012 |
| Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness. | Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, Matsuda J, Seki T, Kumanogoh A., Free PMC Article | 06/16/2012 |
| experiments using knockout mice revealed that Sema4A but not Sema7A was required for the effect produced by Th1 cells on neurite outgrowth from cortical neurons. | Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins.
Ishii H, Kubo T, Kumanogoh A, Yamashita T. | 12/11/2010 |
| Data indicated that Sema4A could function as a chemo-repulsive cue by activating a receptor whose signal is transmitted to Rho-kinase and induced growth cone collapse of hippocampal neurons. | Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner.
Yukawa K, Tanaka T, Bai T, Ueyama T, Owada-Makabe K, Tsubota Y, Maeda M, Suzuki K, Kikutani H, Kumanogoh A. | 01/21/2010 |
| These results indicated that Sema4A is critically involved in experimental autoimmune myocarditis by regulating differentiation of T-cells. | Involvement of Sema4A in the progression of experimental autoimmune myocarditis.
Makino N, Toyofuku T, Takegahara N, Takamatsu H, Okuno T, Nakagawa Y, Kang S, Nojima S, Hori M, Kikutani H, Kumanogoh A. | 01/21/2010 |