| Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism. | Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism.
Sisak S, Chae RC, Nelson KE, Schuster RM, Perez EC, England LG, Caldwell CC, Lentsch AB, Goodman MD, Pritts TA., | 04/16/2024 |
| A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage. | A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage.
Hatchell D, Alshareef M, Vasas T, Guglietta S, Borucki D, Guo C, Mallah K, Eskandari R, Tomlinson S., Free PMC Article | 06/24/2023 |
| Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy. | Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy.
Khan IM, Ulrich BJ, Nelson AS, Sehra S, Kansas GS, Kaplan MH., Free PMC Article | 01/29/2022 |
| Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer. | Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer.
DuRoss AN, Landry MR, Thomas CR Jr, Neufeld MJ, Sun C., Free PMC Article | 06/26/2021 |
| Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes. | Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.
Han P, Hanlon D, Arshad N, Lee JS, Tatsuno K, Robinson E, Filler R, Sobolev O, Cote C, Rivera-Molina F, Toomre D, Fahmy T, Edelson R., Free PMC Article | 11/21/2020 |
| The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway | The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway.
Ye Z, Zhong L, Zhu S, Wang Y, Zheng J, Wang S, Zhang J, Huang R., Free PMC Article | 07/18/2020 |
| P-selectin plays a role in haem-induced acute lung injury in sickle mice. | P-selectin plays a role in haem-induced acute lung injury in sickle mice.
Ghosh S, Flage B, Weidert F, Ofori-Acquah SF., Free PMC Article | 05/30/2020 |
| Vascular endothelial cell expression of JAK2(V617F) is sufficient to promote a pro-thrombotic state due to increased P-selectin expression. | Vascular endothelial cell expression of JAK2(V617F) is sufficient to promote a pro-thrombotic state due to increased P-selectin expression.
Guy A, Gourdou-Latyszenok V, Le Lay N, Peghaire C, Kilani B, Dias JV, Duplaa C, Renault MA, Denis C, Villeval JL, Boulaftali Y, Jandrot-Perrus M, Couffinhal T, James C., Free PMC Article | 05/2/2020 |
| platelet recruitment to lungs in response to LPS occurs through mechanisms distinct from those mediating neutrophil recruitment, or the occurrence of pulmonary emboli, which involve PSGL1 or P-selectin | LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin.
Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC., Free PMC Article | 04/11/2020 |
| Alternatively-activated macrophages-secreted MIP-1beta activates CCR5/PI3K signaling in mesothelial cells, resulting in expression of P-selectin on the mesothelial cell surface. Tumor cells attached to this de novo P-selectin through CD24. C57/BL6 mice treated with MIP-1beta exhibited increased P-selectin expression on mesothelial cells lining peritoneal tissues, which enhanced CaOV3 adhesion ex vivo and ID8 adhesion i... | Alternatively-Activated Macrophages Upregulate Mesothelial Expression of P-Selectin to Enhance Adhesion of Ovarian Cancer Cells.
Carroll MJ, Fogg KC, Patel HA, Krause HB, Mancha AS, Patankar MS, Weisman PS, Barroilhet L, Kreeger PK., Free PMC Article | 08/10/2019 |
| T cells prevent hemorrhagic transformation in ischemic stroke by their capacity to bind platelets through P-selectin. | T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding.
Salas-Perdomo A, Miró-Mur F, Urra X, Justicia C, Gallizioli M, Zhao Y, Brait VH, Laredo C, Tudela R, Hidalgo A, Chamorro Á, Planas AM. | 07/27/2019 |
| Choroid plexus endothelial cells are conventionally polarized, but express P-cadherin at cell-cell contacts, and Lgl2 and syntaxin-4 in the luminal plasma membrane domain. | Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain.
Christensen IB, Mogensen EN, Damkier HH, Praetorius J., Free PMC Article | 03/9/2019 |
| Platelet Ral GTPases primarily control P-selectin surface expression, in turn regulating platelet-leukocyte interaction. | Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction.
Wersäll A, Williams CM, Brown E, Iannitti T, Williams N, Poole AW. | 01/12/2019 |
| In a laser injury-induced thrombosis model, P-selectin modulates thrombus propagation independently of VWF and TSP1 | P-selectin can promote thrombus propagation independently of both von Willebrand factor and thrombospondin-1 in mice.
Prakash P, Nayak MK, Chauhan AK., Free PMC Article | 02/3/2018 |
| deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen. | P-Selectin Sustains Extramedullary Hematopoiesis in the Gata1 low Model of Myelofibrosis.
Spangrude GJ, Lewandowski D, Martelli F, Marra M, Zingariello M, Sancillo L, Rana RA, Migliaccio AR. | 12/17/2016 |
| The present study supported the notion that CD62P accumulation during platelet storage is involved in mediating transfusion-related acute lung injury. | Accumulation of CD62P during storage of apheresis platelet concentrates and the role of CD62P in transfusion-related acute lung injury.
Tong S, Wang H, Zhang T, Chen L, Liu B. | 08/20/2016 |
| Holothurian glycosaminoglycan has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis. | Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells.
Yue Z, Wang A, Zhu Z, Tao L, Li Y, Zhou L, Chen W, Lu Y. | 08/20/2016 |
| Data (including data from studies in transgenic mice) suggest that sequence variations limited to 1.4-kb proximal promoter region account for most differences in expression of murine Selp and human SELP genes. | Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice.
Liu Z, Zhang N, Shao B, Panicker SR, Fu J, McEver RP., Free PMC Article | 06/4/2016 |
| P-selectin has a role in endothelial progenitor cells' inhibition of platelet function | Endothelial progenitor cells inhibit platelet function in a P-selectin-dependent manner.
Abou-Saleh H, Hachem A, Yacoub D, Gillis MA, Merhi Y., Free PMC Article | 04/23/2016 |
| Both platelet and endothelial cell P-selectin contribute to host defense during Klebsiella pneumosepsis. | Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis.
de Stoppelaar SF, Van't Veer C, Roelofs JJ, Claushuis TA, de Boer OJ, Tanck MW, Hoogendijk AJ, van der Poll T. | 02/27/2016 |
| Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism and promotes tumor growth. | P-selectin-mediated platelet adhesion promotes tumor growth.
Qi C, Wei B, Zhou W, Yang Y, Li B, Guo S, Li J, Ye J, Li J, Zhang Q, Lan T, He X, Cao L, Zhou J, Geng J, Wang L., Free PMC Article | 01/23/2016 |
| P-selectin promotes neutrophil extracellular trap (NET) formation and is a potential target for NET-related diseases. | P-selectin promotes neutrophil extracellular trap formation in mice.
Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD., Free PMC Article | 10/10/2015 |
| P-selectin is an important adhesion molecule vital for infiltration of regulatory T cells into mouse mammary tumors | P-selectin enhances growth and metastasis of mouse mammary tumors by promoting regulatory T cell infiltration into the tumors.
Nasti TH, Bullard DC, Yusuf N. | 07/25/2015 |
| Administering human recombinant PTX3 to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice. | Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway.
Carrizzo A, Lenzi P, Procaccini C, Damato A, Biagioni F, Ambrosio M, Amodio G, Remondelli P, Del Giudice C, Izzo R, Malovini A, Formisano L, Gigantino V, Madonna M, Puca AA, Trimarco B, Matarese G, Fornai F, Vecchione C. | 07/4/2015 |
| Targeting P-selectin-mediated platelet adhesion onto endometriotic lesions holds promise as a novel therapeutics for treating endometriosis. | P-selectin as a potential therapeutic target for endometriosis.
Guo SW, Ding D, Geng JG, Wang L, Liu X. | 06/20/2015 |