| [CXCL8 generates an immunosuppressive microenvironment in colorectal cancer through induction of M2 macrophage infiltration and inhibition of CD8[+] T cell infiltration]. | [CXCL8 generates an immunosuppressive microenvironment in colorectal cancer through induction of M2 macrophage infiltration and inhibition of CD8(+) T cell infiltration].
Shao Y, Lan Y, Song B, Sun J, Yang T. | 10/25/2024 |
| IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer. | IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
Wu J, Zhang Q, Wu J, Yang Z, Liu X, Lou C, Wang X, Peng J, Zhang J, Shang Z, Xiao J, Wang N, Zhang R, Zhou J, Wang Y, Hu Z, Zhang R, Zhang J, Zeng Z., Free PMC Article | 03/8/2024 |
| IL-8 Triggers Neutrophil Extracellular Trap Formation Through an Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in Uveitis. | IL-8 Triggers Neutrophil Extracellular Trap Formation Through an Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in Uveitis.
Shu Q, Zhang N, Liu Y, Wang X, Chen J, Xie H, Pan F, Zhao L, Ding X, Wen Y, Wang L, Xie W, Lu J, Su G, Peng H, Yang P., Free PMC Article | 11/18/2023 |
| [IL-8 Links NF-kappaB and Wnt/beta-Catenin Pathways in Persistent Inflammatory Response Induced by Chronic Helicobacter pylori Infection]. | [IL-8 Links NF-κB and Wnt/β-Catenin Pathways in Persistent Inflammatory Response Induced by Chronic Helicobacter pylori Infection].
Lin L, Xie B, Shi J, Zhou CM, Yi J, Chen J, He JX, Wei HL. | 11/6/2023 |
| Overexpression of Interleukin-8 Promotes the Progression of Fatty Liver to Nonalcoholic Steatohepatitis in Mice. | Overexpression of Interleukin-8 Promotes the Progression of Fatty Liver to Nonalcoholic Steatohepatitis in Mice.
Cho YE, Kim Y, Kim SJ, Lee H, Hwang S., Free PMC Article | 11/1/2023 |
| IL-18 deficiency ameliorates the progression from AKI to CKD. | IL-18 deficiency ameliorates the progression from AKI to CKD.
Luan J, Fu J, Jiao C, Hao X, Feng Z, Zhu L, Zhang Y, Zhou G, Li H, Yang W, Yuen PST, Kopp JB, Pi J, Zhou H., Free PMC Article | 12/3/2022 |
| Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8(+) T cells. | Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8(+) T cells.
Li X, Zhai J, Shen Y, Zhang T, Wang Y, He Y, You Q, Shen L., Free PMC Article | 10/29/2022 |
| Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression. | Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression.
Lopez-Bujanda ZA, Haffner MC, Chaimowitz MG, Chowdhury N, Venturini NJ, Patel RA, Obradovic A, Hansen CS, Jacków J, Maynard JP, Sfanos KS, Abate-Shen C, Bieberich CJ, Hurley PJ, Selby MJ, Korman AJ, Christiano AM, De Marzo AM, Drake CG., Free PMC Article | 05/7/2022 |
| Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4. | Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
Yang F, Liu XQ, He JZ, Xian SP, Yang PF, Mai ZY, Li M, Liu Y, Zhang XD., Free PMC Article | 04/16/2022 |
| CXCL15/Lungkine has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner. | CXCL15/Lungkine has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner.
Broxmeyer HE, Cooper SH, Ropa J., Free PMC Article | 01/29/2022 |
| IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway in human IL-8-expressing mice. | IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y. | 01/22/2022 |
| Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the beta2 -adrenergic receptor. | Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the β(2) -adrenergic receptor.
Rich TC, Leavesley SJ, Brandon AP, Evans CA, Raju SV, Wagener BM., Free PMC Article | 10/30/2021 |
| Protein levels of Cxcl8 were increased in plasma, liver and subcutaneous white adipose tissue of db/db mice compared to db/m mice. Results also revealed a significant increase in the mRNA level of CXCL8 in the liver and sWAT tissue of db/db mice | The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.
Cui S, Qiao L, Yu S, Men L, Li Y, Li F, Du J. | 04/18/2020 |
| inflammation triggered property of Microcystin-LR via IL-8/CXCR2 signaling | The role of IL-8/CXCR2 signaling in microcystin-LR triggered endothelial cell activation and increased vascular permeability.
Chen L, Liu X, Pan Z, Liu S, Han H, Zhao C, Tang X. | 04/21/2018 |
| Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-kappaB signaling pathway in mouse skin. | Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin.
Tang SC, Liao PY, Hung SJ, Ge JS, Chen SM, Lai JC, Hsiao YP, Yang JH. | 03/10/2018 |
| Parenchymal polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC), have a positive correlation with IL1a, IL8, CXCL5, and Mip-1a, suggesting they may attract PMN-MDSC into the tumor | Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α.
Najjar YG, Rayman P, Jia X, Pavicic PG Jr, Rini BI, Tannenbaum C, Ko J, Haywood S, Cohen P, Hamilton T, Diaz-Montero CM, Finke J., Free PMC Article | 02/24/2018 |
| this study shows that ponciretin may attenuate ethanol-induced gastritis via the regulation of IL-8 secretion | Ponciretin attenuates ethanol-induced gastric damage in mice by inhibiting inflammatory responses.
Kang GD, Kim DH. | 04/15/2017 |
| Adh binds to OR5M11, which enhances Actinobacillus pleuropneumoniae pathogenicity by activating p38 which induces apoptosis of PAMs and IL-8 release | Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release.
Wang L, Qin W, Zhang J, Bao C, Zhang H, Che Y, Sun C, Gu J, Feng X, Du C, Han W, Richard PL, Lei L., Free PMC Article | 04/1/2017 |
| Data suggest that CXCL1/IL-8, released from osteoclasts in an autoantibody-dependent manner, produces pain by activating sensory neurons. | Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism.
Wigerblad G, Bas DB, Fernades-Cerqueira C, Krishnamurthy A, Nandakumar KS, Rogoz K, Kato J, Sandor K, Su J, Jimenez-Andrade JM, Finn A, Bersellini Farinotti A, Amara K, Lundberg K, Holmdahl R, Jakobsson PJ, Malmström V, Catrina AI, Klareskog L, Svensson CI., Free PMC Article | 07/30/2016 |
| Findings suggest that IL8-dependent osteoclast activation may constitute an early event in the initiation of the joint specific inflammation in anti-citrullinated protein-positive rheumatoid arthritis. | Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.
Krishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, Ytterberg AJ, Engström M, Fernandes-Cerqueira C, Amara K, Magnusson M, Wigerblad G, Kato J, Jiménez-Andrade JM, Tyson K, Rapecki S, Lundberg K, Catrina SB, Jakobsson PJ, Svensson C, Malmström V, Klareskog L, Wähämaa H, Catrina AI., Free PMC Article | 07/30/2016 |
| IL-8 signaling is up-regulated in alcoholic hepatitis. | IL-8 signaling is up-regulated in alcoholic hepatitis and DDC fed mice with Mallory Denk Bodies (MDBs) present.
Liu H, French BA, Nelson TJ, Li J, Tillman B, French SW., Free PMC Article | 02/6/2016 |
| expressions of IL-1beta and IL-8 in the brain increased after ApoE knockout in mice | [ApoE gene knockout causes high expressions of TNF-α, IL-1β and IL-8 in mouse brain].
Li B, Huang D, Gui L, Qi W, Jia X, Lu B. | 11/14/2015 |
| CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via MKP-1-dependent inhibition of ERK. | CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK.
Wang WY, Komatsu K, Huang Y, Wu J, Zhang W, Lee JY, Miyata M, Xu H, Li JD., Free PMC Article | 07/25/2015 |
| Taken together, these results indicate that CD147 promotes lung cancer-induced osteoclastogenesis by modulating IL-8 secretion, and suggest that CD147 is a potential therapeutic target for cancer-associated bone resorption in lung cancer patients. | CD147 deficiency blocks IL-8 secretion and inhibits lung cancer-induced osteoclastogenesis.
Wang H, Zhuo Y, Hu X, Shen W, Zhang Y, Chu T. | 05/2/2015 |
| these data outline a novel role for the P2Y6 receptor in the induction of CXCL8/IL-8 production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI. | The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.
Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA., Free PMC Article | 01/3/2015 |