| High expression of AK1 predicts inferior prognosis in acute myeloid leukemia patients undergoing chemotherapy. | High expression of AK1 predicts inferior prognosis in acute myeloid leukemia patients undergoing chemotherapy.
Qin T, Zhao H, Shao Y, Hu N, Shi J, Fu L, Zhang Y., Free PMC Article | 03/27/2021 |
| A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. | A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma.
Jan YH, Lai TC, Yang CJ, Huang MS, Hsiao M., Free PMC Article | 10/24/2020 |
| Specific DNA methylation signatures for aggressive choroid plexus carcinoma (CPC) revealed AK1, PER2, and PLSCR4 as potential biomarkers for CPC that can be used to improve molecular stratification for diagnosis and treatment. | DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.
Pienkowska M, Choufani S, Turinsky AL, Guha T, Merino DM, Novokmet A, Brudno M, Weksberg R, Shlien A, Hawkins C, Bouffet E, Tabori U, Gilbertson RJ, Finlay JL, Jabado N, Thomas C, Sill M, Capper D, Hasselblatt M, Malkin D., Free PMC Article | 06/20/2020 |
| The mRNA and protein expressions of AK1, AK6 and AK7 are significantly down-regulated in the sperm of asthenospermia patients, which may be closely related with reduced sperm motility. | [Expressions of the adenylate kinase family in asthenospermia].
Wang HS, Zhu Y, Sun F. | 05/23/2020 |
| Case Reports: first case of adenylate kinase deficiency in Indian population due to novel AK1 mutations (c.71A>G and c.413G>A) associated with nonspherocytic haemolytic anaemia without psychomotor impairment. | Red cell adenylate kinase deficiency in India: identification of two novel missense mutations (c.71A>G and c.413G>A).
Dongerdiye R, Kamat P, Jain P, Warang P, Devendra R, Wasekar N, Sharma R, Mhaskar K, Madkaikar MR, Manglani MV, Kedar PS. | 06/1/2019 |
| Studies indicate that the preferred substrate and phosphate donor of all adenylate kinases are AMP and ATP respectively. | The many isoforms of human adenylate kinases.
Panayiotou C, Solaroli N, Karlsson A. | 11/22/2014 |
| Dysregulation of AMPK is both a pathogenic factor for these disorders in humans and a target for their prevention and therapy. [Review] | AMPK, insulin resistance, and the metabolic syndrome.
Ruderman NB, Carling D, Prentki M, Cacicedo JM., Free PMC Article | 10/19/2013 |
| Ak(1)2-1 phenotype is more frequent in males conceived in the summer-autumn period than in those conceived in winter-spring, and this association depends on maternal Ak(1) phenotype. | Ak(1) genetic polymorphism and season of conception.
Gloria-Bottini F, Neri A, Pietropolli A, Bottini E, Magrini A. | 08/10/2013 |
| identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides | Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
Yegutkin GG, Wieringa B, Robson SC, Jalkanen S., Free PMC Article | 12/29/2012 |
| Data indicate that the neuronal adenylate kinase-1 (AK1) is induced by Abeta(42) to increase abnormal tau phosphorylation via AMPK-GSK3beta and contributes to tau-mediated neurodegeneration. | Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.
Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, Jung YK. | 10/13/2012 |
| AK1 phenotypic activity is associated with birth weight and placental weight; these associations are greater in infants born at gestational age greater than 38 weeks. | Adenylate kinase locus 1 polymorphism and feto-placental development.
Fulvia GB, Antonio P, Anna N, Patrizia S, Ada A, Egidio B, Andrea M. | 04/28/2012 |
| Our findings suggest a reduced reproductive efficiency of women carrying the Ak(1)2-1 phenotype: this could have practical importance in predicting the probability of reproductive success in couples with RSA | Adenylate kinase genetic polymorphism and spontaneous abortion.
Gloria-Bottini F, Nicotra M, Amante A, Pietropolli A, Neri A, Bottini E, Magrini A. | 04/14/2012 |
| The adipokine zinc-alpha2-glycoprotein activates AMP kinase in human primary skeletal muscle cells. | The adipokine zinc-α2-glycoprotein activates AMP kinase in human primary skeletal muscle cells.
Eckardt K, Schober A, Platzbecker B, Mracek T, Bing C, Trayhurn P, Eckel J. | 08/13/2011 |
| the correlation between blood glucose and glycated Hb in relation to AK1 and ACP1 polymorphism was studied. | The effect of genetic variability on the correlation between blood glucose and glycated hemoglobin levels.
Gloria-Bottini F, Antonacci E, Cozzoli E, De Acetis C, Bottini E. | 03/5/2011 |
| The data suggest that zygotes carrying AK1*2 allele are relatively protected from the damaging effects of smoking | Smoking and human reproduction: the effect of adenylate kinase genetic polymorphism.
Gloria-Bottini F, Magrini A, Pietropolli A, Bergamaschi A, Bottini E, Gloria-Bottini F, Magrini A, Pietropolli A, Bergamaschi A, Bottini E. | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Smoking and human reproduction: the effect of adenylate kinase genetic polymorphism.
Gloria-Bottini F, Magrini A, Pietropolli A, Bergamaschi A, Bottini E, Gloria-Bottini F, Magrini A, Pietropolli A, Bergamaschi A, Bottini E. | 11/2/2008 |
| The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 1 | Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
Topalis D, Alvarez K, Barral K, Munier-Lehmann H, Schneider B, Véron M, Guerreiro C, Mulard L, El-Amri C, Canard B, Deville-Bonne D. | 01/21/2010 |
| how mutations found in 2 patients may affect enzyme structure and function; a compound heterozygote for 2 different missense mutations 118G>A(Gly40Arg) and 190G>A(Gly64Arg); a homozygote for either aspartic acid (Asp) 140 or 141 | Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.
Corrons JL, Garcia E, Tusell JJ, Varughese KI, West C, Beutler E. | 01/21/2010 |
| analysis of vascular endothelial ectoadenylate kinase and plasma membrane ATP synthase | Ectoadenylate kinase and plasma membrane ATP synthase activities of human vascular endothelial cells.
Quillen EE, Haslam GC, Samra HS, Amani-Taleshi D, Knight JA, Wyatt DE, Bishop SC, Colvert KK, Richter ML, Kitos PA. | 01/21/2010 |