| Regulatory role and translational potential of CCL11 in liver fibrosis. | Regulatory role and translational potential of CCL11 in liver fibrosis.
Kong M, Dong W, Kang A, Kuai Y, Xu T, Fan Z, Shi L, Sun D, Lu Y, Li Z, Xu Y. | 06/26/2023 |
| Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement. | Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement.
Tashiro R, Ozaki D, Bautista-Garrido J, Sun G, Obertas L, Mobley AS, Kim GS, Aronowski J, Jung JE., Free PMC Article | 03/30/2023 |
| Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration. | Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration.
Fan Z, Kong M, Dong W, Dong C, Miao X, Guo Y, Liu X, Miao S, Li L, Chen T, Qu Y, Yu F, Duan Y, Lu Y, Zou X., Free PMC Article | 06/11/2022 |
| CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis. | CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis.
Polosukhina D, Singh K, Asim M, Barry DP, Allaman MM, Hardbower DM, Piazuelo MB, Washington MK, Gobert AP, Wilson KT, Coburn LA., Free PMC Article | 01/8/2022 |
| Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors. | Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors.
Déry L, Charest G, Guérin B, Akbari M, Fortin D., Free PMC Article | 12/18/2021 |
| Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus. | Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus.
Scabia G, Testa G, Scali M, Del Turco S, Desiato G, Berardi N, Sale A, Matteoli M, Maffei L, Maffei M, Mainardi M, “Train the Brain” Consortium. | 12/18/2021 |
| Zinc Oxide Nanowires Exposure Induces a Distinct Inflammatory Response via CCL11-Mediated Eosinophil Recruitment. | Zinc Oxide Nanowires Exposure Induces a Distinct Inflammatory Response via CCL11-Mediated Eosinophil Recruitment.
Alghsham RS, Satpathy SR, Bodduluri SR, Hegde B, Jala VR, Twal W, Burlison JA, Sunkara M, Haribabu B., Free PMC Article | 10/24/2020 |
| Exogenous CCL11 was internalised in osteoclast and stimulated the migration of pre-osteoclast and concomitant increase in bone resorption. | CCL11, a novel mediator of inflammatory bone resorption.
Kindstedt E, Holm CK, Sulniute R, Martinez-Carrasco I, Lundmark R, Lundberg P., Free PMC Article | 02/9/2019 |
| SNPs in CCL11 and CCL4 were associated with elevated plasma chemokine levels in fibromyalgia patients. | SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study.
Zhang Z, Feng J, Mao A, Le K, La Placa D, Wu X, Longmate J, Marek C, St Amand RP, Neuhausen SL, Shively JE., Free PMC Article | 01/5/2019 |
| the adipose-derived FGF21-CCL11 axis triggers cold-induced beiging and thermogenesis by coupling sympathetic nervous system to activation of type 2 immunity in subcutaneous white adipose tissue. | The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.
Huang Z, Zhong L, Lee JTH, Zhang J, Wu D, Geng L, Wang Y, Wong CM, Xu A. | 05/12/2018 |
| CCL11 promotes migration and proliferation of mouse neural progenitor cells. | CCL11 promotes migration and proliferation of mouse neural progenitor cells.
Wang F, Baba N, Shen Y, Yamashita T, Tsuru E, Tsuda M, Maeda N, Sagara Y., Free PMC Article | 11/11/2017 |
| These studies characterized serum and intestinal wall eotaxin-1 levels in various inflammatory bowel disease patients and to explore the effect of targeting eotaxin-1 by specific antibodies in dextran sodium sulfate-induced colitis model. | The Importance of Intestinal Eotaxin-1 in Inflammatory Bowel Disease: New Insights and Possible Therapeutic Implications.
Adar T, Shteingart S, Ben-Ya'acov A, Shitrit AB, Livovsky DM, Shmorak S, Mahamid M, Melamud B, Vernea F, Goldin E. | 07/15/2017 |
| this study shows that eosinophil trafficking to the heart is dependent on the eotaxin-CCR3 pathway in a mouse model of experimental autoimmune myocarditis | Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.
Diny NL, Hou X, Barin JG, Chen G, Talor MV, Schaub J, Russell SD, Klingel K, Rose NR, Čiháková D., Free PMC Article | 07/8/2017 |
| Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4(+) and CD8(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP-intoxicated mice. | Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.
Chandra G, Rangasamy SB, Roy A, Kordower JH, Pahan K., Free PMC Article | 04/15/2017 |
| These results indicate that CCL11 was responsible for the limited angiogenesis and necrosis by inducing and attracting eosinophils in the tumors. | CCL11-induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis.
Xing Y, Tian Y, Kurosawa T, Matsui S, Touma M, Yanai T, Wu Q, Sugimoto K. | 01/14/2017 |
| Study demonstrated that CCL11 is primarily produced by activated astrocytes in the CNS, activates microglia to produce ROS via NOX1, and exacerbates excitotoxic neuronal death | CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia.
Parajuli B, Horiuchi H, Mizuno T, Takeuchi H, Suzumura A. | 07/30/2016 |
| PAR2 activation through endogenous mast cell tryptase activity could be required, at least partially, to mediate CCL11-induced eosinophil migration | Proteinase-activated receptor 2 blockade impairs CCL11- or allergen-induced eosinophil recruitment in experimental pleurisy.
Matos NA, Silva JF, Damasceno KA, Cassali GD, Lemos VS, Duarte ID, Klein A. | 02/6/2016 |
| The chemokines monocyte chemotactic protein 1 (MCP1), MIP1alpha, MIP1beta, interferon gamma-induced protein 10 (IP-10), and eotaxin were induced in Saa1 TG mice. | Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice.
Ji YR, Kim HJ, Bae KB, Lee S, Kim MO, Ryoo ZY., Free PMC Article | 08/1/2015 |
| Aged mice had similar levels of IL-1beta, TNF, IFN-gamma, IL-17, and granulocyte colony-stimulating factor following S. pneumoniae infection, compared with young mice, but increased levels of the chemokines CXCL9, CXCL12, CCL3, CCL4, CCL5, CCL11, and CCL17. | Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.
Williams AE, José RJ, Brown JS, Chambers RC., Free PMC Article | 05/16/2015 |
| Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression. | Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression.
Wan D, Zhang X, Liu X, Li G. | 04/19/2014 |
| investigated role of Eotaxin-1 on disease outcome in Litomosoides sigmodontis infection; findings suggest, in Eotaxin-1(-/-) mice, potential reduced activation state of eosinophils; macrophages produce decreased amounts of IL-6 in vitro suggesting possible mechanisms by which Eotaxin-1 regulates activation of inflammatory cells and parasite survival | Eotaxin-1 is involved in parasite clearance during chronic filarial infection.
Gentil K, Lentz CS, Rai R, Muhsin M, Kamath AD, Mutluer O, Specht S, Hübner MP, Hoerauf A. | 04/19/2014 |
| Autologous transfer of peritoneal macrophages in to the airways of asthmatic mice reduces eotaxin production. | Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model.
Beal DR, Stepien DM, Natarajan S, Kim J, Remick DG., Free PMC Article | 02/1/2014 |
| TNC expression controls eotaxin level in apo E-/- mice and that this chemokine plays a key role in the development of atherosclerosis | Tenascin-C deficiency in apo E-/- mouse increases eotaxin levels: implications for atherosclerosis.
Wang L, Shah PK, Wang W, Song L, Yang M, Sharifi BG., Free PMC Article | 09/21/2013 |
| Data indicate that the combination of Ovalbumin (OVA) and hypoxia induced a enhanced expression of HIF-1alpha and increased eotaxin-1, lung TGB-beta1 expression, and indices of airway remodeling. | Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.
Baek KJ, Cho JY, Rosenthal P, Alexander LEC, Nizet V, Broide DH., Free PMC Article | 05/25/2013 |
| presence of IL-4 in combination with eotaxin-1 in the allergic inflammatory milieu could potentiate infiltration of eosinophils into the lungs | IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro.
Heller NM, Gwinn WM, Donnelly RP, Constant SL, Keegan AD., Free PMC Article | 01/5/2013 |