| Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination. | Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination.
Huang W, Chen ACH, Wei X, Fong SW, Yeung WSB, Lee YL., Free PMC Article | 07/3/2024 |
| Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain. | Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
Valverde A, Dunys J, Lorivel T, Debayle D, Gay AS, Lacas-Gervais S, Roques BP, Chami M, Checler F., Free PMC Article | 02/19/2022 |
| Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis. | Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis.
Aung M, Konoshita T, Moodley J, Naicker T, Connolly C, Khaliq OP, Gathiram P. | 08/28/2021 |
| We suggest that APA enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner | Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.
Chuang HY, Jiang JK, Yang MH, Wang HW, Li MC, Tsai CY, Jhang YY, Huang JC., Free PMC Article | 10/14/2017 |
| The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. | Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa.
Malinauskas M, Wallenius V, Fändriks L, Casselbrant A. | 10/1/2016 |
| This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms. | Altered glutamyl-aminopeptidase activity and expression in renal neoplasms.
Blanco L, Sanz B, Perez I, Sánchez CE, Cándenas ML, Pinto FM, Gil J, Casis L, López JI, Larrinaga G., Free PMC Article | 12/20/2014 |
| miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9. | miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.
Feliciano A, Castellvi J, Artero-Castro A, Leal JA, Romagosa C, Hernández-Losa J, Peg V, Fabra A, Vidal F, Kondoh H, Ramón Y Cajal S, Lleonart ME., Free PMC Article | 08/9/2014 |
| These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation | Structural insights into central hypertension regulation by human aminopeptidase A.
Yang Y, Liu C, Lin YL, Li F., Free PMC Article | 12/14/2013 |
| There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls | Does the aminopeptidase A have prognostic and diagnostic value in Chagas disease and other dilated cardiomyopathies?
Wang Y, Moreira Mda C, Heringer-Walther S, Khan A, Schultheiss HP, Wessel N, Siems WE, Walther T. | 08/4/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The activity of glutamyl aminopeptidase was significally increased in head and neck squamous cell carcinoma tissue. | Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Pérez I, Varona A, Blanco L, Gil J, Santaolalla F, Zabala A, Ibarguen AM, Irazusta J, Larrinaga G. | 01/21/2010 |
| Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression. | Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells.
Teranishi J, Ishiguro H, Hoshino K, Noguchi K, Kubota Y, Uemura H. | 01/21/2010 |
| Over-expressed APA drastically reduces, in a calcium dependent manner, full-length-Abeta but not amyloid-beta precursor protein (APP) intracellular domain in a cell-free model of Abeta production. | Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide.
Sevalle J, Amoyel A, Robert P, Fournié-Zaluski MC, Roques B, Checler F. | 01/21/2010 |
| A novel nonsense polymorphism in the aminopeptidase-a gene was associated with hypertension among postmenopausal women, and those with marginal calcium and vitamin D intake. | Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factors.
Forman JP, Fisher ND, Pollak MR, Cox DG, Tonna S, Curhan GC., Free PMC Article | 01/21/2010 |
| Data show that brain aminopeptidases act upon Ang I, Ang II and Ang III in order to activate brain AT(1) receptors. | The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain.
Speth RC, Karamyan VT. | 01/21/2010 |
| The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin angiotensin system. | Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei.
de Mota N, Iturrioz X, Claperon C, Bodineau L, Fassot C, Roques BP, Palkovits M, Llorens-Cortes C. | 01/21/2010 |
| Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II. | New insights into the importance of aminopeptidase A in hypertension.
Mizutani S, Ishii M, Hattori A, Nomura S, Numaguchi Y, Tsujimoto M, Kobayshi H, Murohara T, Wright JW., Free PMC Article | 01/21/2010 |
| Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. | Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.
Tsujimoto M, Goto Y, Maruyama M, Hattori A. | 01/21/2010 |
| rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study | Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS).
Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR, Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR., Free PMC Articles: PMC2705935, PMC2705935 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS).
Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR, Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR. | 04/3/2008 |
| Rieger syndrome with microdeletions including only the PITX2 and ENPEP (glutamyl aminopeptidase) genes. | Cytogenetically invisible microdeletions involving PITX2 in Rieger syndrome.
Engenheiro E, Saraiva J, Carreira I, Ramos L, Ropers HH, Silva E, Tommerup N, Tümer Z. | 01/21/2010 |