| Bone marrow monocytes and macrophages from mice lacking betaENaC and ASIC2 have a reduced chemotactic migration response and polarization. | Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization.
Wasson R, Fleming AB, McLin J, Hildebrandt E, Drummond HA., Free PMC Article | 08/5/2024 |
| Neutrophil extracellular traps are present in the airways of ENaC-overexpressing mice with cystic fibrosis-like lung disease. | Neutrophil extracellular traps are present in the airways of ENaC-overexpressing mice with cystic fibrosis-like lung disease.
Tucker SL, Sarr D, Rada B., Free PMC Article | 12/11/2021 |
| Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing Scnn1b-Tg(+) Mice Lungs. | Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing Scnn1b-Tg(+) Mice Lungs.
Choudhary I, Vo T, Paudel K, Yadav R, Mao Y, Patial S, Saini Y., Free PMC Article | 08/21/2021 |
| The SPLUNC1-betaENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia. | The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.
Ahmad S, Kim CSK, Tarran R., Free PMC Article | 06/12/2021 |
| Scnn1b-Transgenic BALB/c Mice as a Model of Pseudomonas aeruginosa Infections of the Cystic Fibrosis Lung. | Scnn1b-Transgenic BALB/c Mice as a Model of Pseudomonas aeruginosa Infections of the Cystic Fibrosis Lung.
Brao KJ, Wille BP, Lieberman J, Ernst RK, Shirtliff ME, Harro JM., Free PMC Article | 03/6/2021 |
| Apical fluid shear stress specifically downregulates beta-ENaC and gamma-ENaC subunits at the transcriptional level through an unidentified heat-insensitive paracrine basolateral factor in collecting duct principal cells. | Uninephrectomy and apical fluid shear stress decrease ENaC abundance in collecting duct principal cells.
Ernandez T, Udwan K, Chassot A, Martin PY, Feraille E. | 09/7/2019 |
| Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron. | Physiological regulation of the epithelial Na(+) channel by casein kinase II.
Berman JM, Mironova E, Stockand JD., Free PMC Article | 05/4/2019 |
| N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel. | N-linked glycans are required on epithelial Na(+) channel subunits for maturation and surface expression.
Kashlan OB, Kinlough CL, Myerburg MM, Shi S, Chen J, Blobner BM, Buck TM, Brodsky JL, Hughey RP, Kleyman TR., Free PMC Article | 05/4/2019 |
| Scnn1b-Tg mice exhibited an approximately 50% reduction mucociliary clearance | Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.
Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. | 09/1/2018 |
| Loss of betaENaC function resulted in meibomian gland disease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 MG disease and was sex dependent. | Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.
Yu D, Saini Y, Chen G, Ghio AJ, Dang H, Burns KA, Wang Y, Davis RM, Randell SH, Esther CR Jr, Paulsen F, Boucher RC., Free PMC Article | 01/13/2018 |
| The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells. | Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC.
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X. | 08/12/2017 |
| Nedd4-2-mediated ubiquitination of beta-ENaC leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport. | Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.
Gille T, Randrianarison-Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, Hummler E, Clerici C, Planès C. | 04/26/2014 |
| Data indicate that insulin receptor (InsR) is important for epithelial sodium channel (ENaC) activity. | Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.
Pavlov TS, Ilatovskaya DV, Levchenko V, Li L, Ecelbarger CM, Staruschenko A., Free PMC Article | 09/21/2013 |
| Our findings are consistent with the role of betaENaC as a vascular smooth muscle cell mechanosensor and function of evolutionarily related nematode degenerin proteins. | βENaC is required for whole cell mechanically gated currents in renal vascular smooth muscle cells.
Chung WS, Weissman JL, Farley J, Drummond HA., Free PMC Article | 08/31/2013 |
| These data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity in the kidney. | Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.
Roos KP, Bugaj V, Mironova E, Stockand JD, Ramkumar N, Rees S, Kohan DE., Free PMC Article | 03/30/2013 |
| Cys substitutions at sites in the wrist domains of the beta and gamma subunits alter the Na+ self-inhibition response. | Role of the wrist domain in the response of the epithelial sodium channel to external stimuli.
Shi S, Carattino MD, Kleyman TR., Free PMC Article | 03/30/2013 |
| ENaC is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation. | The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation.
Edinger RS, Bertrand CA, Rondandino C, Apodaca GA, Johnson JP, Butterworth MB., Free PMC Article | 02/23/2013 |
| These findings demonstrate that myogenic constriction in afferent arterioles is dependent on normal expression of betaENaC | Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced βENaC expression.
Ge Y, Gannon K, Gousset M, Liu R, Murphey B, Drummond HA., Free PMC Article | 08/4/2012 |
| loss of beta-ENaC associated with early signs of renal injury and increased mean arterial pressure | Renal inflammation and elevated blood pressure in a mouse model of reduced {beta}-ENaC.
Drummond HA, Grifoni SC, Abu-Zaid A, Gousset M, Chiposi R, Barnard JM, Murphey B, Stec DE., Free PMC Article | 10/8/2011 |
| generation of transgenic mice with airway-specific overexpression of the epithelial Na(+) channel (ENaC) is an alternative approach to mimic cystic fibrosis ion transport pathophysiology in the lung | The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou Z, Duerr J, Johannesson B, Schubert SC, Treis D, Harm M, Graeber SY, Dalpke A, Schultz C, Mall MA. | 09/3/2011 |
| Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. | Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.
Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC., Free PMC Article | 09/20/2010 |
| Il-6 activates ENaC-beta channels in cortical collecting duct cells. | Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells.
Li K, Guo D, Zhu H, Hering-Smith KS, Hamm LL, Ouyang J, Dong Y., Free PMC Article | 09/13/2010 |
| Dot1a and AF9 downregulate Na(+) transport, most likely by regulating ENaC mRNA and subsequent protein expression and ENaC activity. | Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.
Reisenauer MR, Wang SW, Xia Y, Zhang W., Free PMC Article | 07/19/2010 |
| Beta-ENaC is an important mediator of renal myogenic constriction-mediated renal blood flow autoregulation in vivo. | Altered whole kidney blood flow autoregulation in a mouse model of reduced beta-ENaC.
Grifoni SC, Chiposi R, McKey SE, Ryan MJ, Drummond HA., Free PMC Article | 03/15/2010 |
| Middle cerebral artery pressure-induced constriction is inhibited in a mouse model of reduced betaENaC. | Pressure-induced constriction is inhibited in a mouse model of reduced betaENaC.
VanLandingham LG, Gannon KP, Drummond HA., Free PMC Article | 01/21/2010 |