| Engrailed 2 serves as a master regulator of the super-enhancer in the TNC gene locus in non-small cell lung cancer. | Engrailed 2 serves as a master regulator of the super-enhancer in the TNC gene locus in non-small cell lung cancer.
Li Y, Jiang J, Wang X, Cao Y, Tang L, Song X, Huang F, Li M, Chen F, Wan H, Ye S. | 02/9/2024 |
| Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer. | Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer.
Lee Y, Dho SH, Lee J, Hwang JH, Kim M, Choi WY, Lee JY, Lee J, Chang W, Lee MY, Choi J, Kim TY, Kim LK., Free PMC Article | 04/23/2022 |
| Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis. | Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis.
Xie L, Pan Z., Free PMC Article | 11/22/2021 |
| Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP2. | Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP(2).
Amblard I, Dupont E, Alves I, Miralvès J, Queguiner I, Joliot A. | 07/31/2021 |
| EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer. | EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.
Li Y, Liu J, Xiao Q, Tian R, Zhou Z, Gan Y, Li Y, Shu G, Yin G., Free PMC Article | 03/27/2021 |
| Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression. | Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression.
Li Q, Shi Y, Sa R, Hao J, Hu J, Xiao M, Wang C, Yan L, Qiao B, Chen G., Free PMC Article | 01/16/2021 |
| Membrane insertion and secretion of the Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma. | Membrane insertion and secretion of the Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma.
Punia N, Primon M, Simpson GR, Pandha HS, Morgan R., Free PMC Article | 10/3/2020 |
| Urine Engrailed-2 (EN2) has no value as prostate cancer prognostic biomarker. | Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?
Do Carmo Silva J, Vesely S, Novak V, Luksanova H, Prusa R, Babjuk M. | 06/6/2020 |
| The EN2 transcription factor is a novel ovarian cancer biomarker. It demonstrates prognostic value, correlating with worse Overall Survival and Progression-free Survival. | Engrailed-2 (EN2) - a novel biomarker in epithelial ovarian cancer.
McGrath SE, Annels N, Madhuri TK, Tailor A, Butler-Manuel SA, Morgan R, Pandha H, Michael A., Free PMC Article | 12/22/2018 |
| we confirmed that engrailed-2 is the target of hsa-miR-27b in human cytomegalovirus-infected glioma cells | Hsa-miR-27b is up-regulated in cytomegalovirus-infected human glioma cells, targets engrailed-2 and inhibits its expression.
Wang L, Yang M, Liao S, Liu W, Dai G, Wu G, Chen L., Free PMC Article | 10/27/2018 |
| The critical role of miR212 in inhibiting prostate tumor growth was verified in xenograft models of prostate cancer. These findings highlighted the role of miR212 in PCa progression. More importantly, we speculate that EN-2 is a direct target gene of miR212. | The biological functions and mechanism of miR‑212 in prostate cancer proliferation, migration and invasion via targeting Engrailed-2.
Zhou Y, Ji Z, Yan W, Zhou Z, Li H., Free PMC Article | 04/21/2018 |
| We identified a novel heterozygous missense variant (c.425C>G, p.Pro142Arg) in the Engrailed 2 (EN2) gene in two patients. The G variant has never been reported in public databases and was absent in 100 Thai patients with ASD and 435 Thai controls. A case-control study showed that the G allele of c.425C>G was significantly associated with ASD | Whole-exome sequencing identifies a novel heterozygous missense variant of the EN2 gene in two unrelated patients with autism spectrum disorder.
Hnoonual A, Sripo T, Limprasert P. | 12/23/2017 |
| EN2 is negatively regulated by miR-605, and down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer (PCa) cells by up-regulating EN2, which leads to PCa development and progression | Down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer cells by up-regulating EN2.
Zhou YJ, Yang HQ, Xia W, Cui L, Xu RF, Lu H, Xue Z, Zhang B, Tian ZN, Cao YJ, Xing ZY, Yin S, He XZ. | 11/4/2017 |
| Our data suggest that the functional interaction of miR-33a and EN-2 is involved in tumorigenesis of prostate cancer | Biological function and mechanism of miR-33a in prostate cancer survival and metastasis: via downregulating Engrailed-2.
Li Q, Lu S, Li X, Hou G, Yan L, Zhang W, Qiao B. | 05/13/2017 |
| the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells. | Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma.
Lai CY, Xu Y, Yu GS, Wu X, Li YF, Pan B, Heng BL, Xue YJ, Su ZX. | 02/18/2017 |
| EN2 may be a candidate oncogene in bladder cancer by activating the PI3K/Akt pathway and inhibiting PTEN. | Repression of engrailed 2 inhibits the proliferation and invasion of human bladder cancer in vitro and in vivo.
Li Y, Liu H, Lai C, Su Z, Heng B, Gao S. | 01/2/2016 |
| Engrailed-2 (EN-2) is a developmentally regulated homeobox gene that is essential for Purkinje cell maturation and normal cerebellar development and patterning. | Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.
James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP., Free PMC Article | 11/7/2015 |
| The mean EN2 levels in prostate cancer patients were 3.76-fold higher than those in non-prostate patients after prostate massage. | Engrailed-2 protein as a potential urinary prostate cancer biomarker: a comparison study before and after digital rectal examination.
Marszałł MP, Sroka W, Adamowski M, Słupski P, Jarzemski P, Siódmiak J, Odrowąż-Sypniewska G. | 08/1/2015 |
| The exact role of EN2 expression in renal carcinoma carcinogenesis requires further investigation. | Engrailed-2 is down-regulated but also ectopically expressed in clear cell renal cell carcinoma.
Lai CY, Pan B, Luo Y, Liang WB, Chen J, Ye DM, Guo JN, Li L, Su ZX. | 02/14/2015 |
| En2 identified as a new regulator of T-cell differentiation whose disruption induces a malignant T-cell fate in chronic myelogenous leukemia progression. | Lineage-specific function of Engrailed-2 in the progression of chronic myelogenous leukemia to T-cell blast crisis.
Abollo-Jiménez F, Campos-Sánchez E, Toboso-Navasa A, Vicente-Dueñas C, González-Herrero I, Alonso-Escudero E, González M, Segura V, Blanco O, Martínez-Climent JA, Sánchez-García I, Cobaleda C., Free PMC Article | 01/17/2015 |
| Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in MID1 and EN2 genes regulating axon guidance pathway. | Exome sequencing and diffusion tensor imaging in developmental disabilities.
Sundaram S, Huq AH, Hsia T, Chugani H., Free PMC Article | 11/8/2014 |
| EN2 levels are increased in affected individuals with an A-C/G-T genotype, supporting EN2 as an autism spectrum disorder susceptibility gene. | Autism associated gene, engrailed2, and flanking gene levels are altered in post-mortem cerebellum.
Choi J, Ababon MR, Soliman M, Lin Y, Brzustowicz LM, Matteson PG, Millonig JH., Free PMC Article | 10/18/2014 |
| urinary EN2 has the potential to be a more sensitive and specific protein biomarker for non-muscle-invasive bladder cancer than currently available tests. | Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker.
Morgan R, Bryan RT, Javed S, Launchbury F, Zeegers MP, Cheng KK, James ND, Wallace DM, Hurst CD, Ward DG, Knowles MA, Pandha H. | 04/12/2014 |
| Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals | Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men.
Killick E, Morgan R, Launchbury F, Bancroft E, Page E, Castro E, Kote-Jarai Z, Aprikian A, Blanco I, Clowes V, Domchek S, Douglas F, Eccles D, Evans DG, Harris M, Kirk J, Lam J, Lindeman G, Mitchell G, Pachter N, Selkirk C, Tucker K, Zgajnar J, Eeles R, Pandha H., Free PMC Article | 10/19/2013 |
| Normal EN-2 downregulation may not occur in some individuals with autism, such that the postnatal persistence of EN-2 overexpression may contribute to autism cerebellar abnormalities. | Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum.
James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP., Free PMC Article | 08/31/2013 |