| EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway. | EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway.
Zhou X, Dong S, Zhou Y, He Z, Zhang Z, Liao L, Zou B, Zheng X, Peng K, Duan X. | 04/25/2024 |
| Spatial control of astrogenesis progression by cortical arealization genes. | Spatial control of astrogenesis progression by cortical arealization genes.
Santo M, Rigoldi L, Falcone C, Tuccillo M, Calabrese M, Martínez-Cerdeño V, Mallamaci A. | 03/21/2023 |
| Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. | Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis.
Jimenez-García MP, Lucena-Cacace A, Otero-Albiol D, Carnero A., Free PMC Article | 01/15/2022 |
| Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2. | Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2.
Jimenez-García MP, Lucena-Cacace A, Otero-Albiol D, Carnero A., Free PMC Article | 10/16/2021 |
| Low EMX2 expression is associated with multiple myeloma. | Wnt and BMP signaling pathways co-operatively induce the differentiation of multiple myeloma mesenchymal stem cells into osteoblasts by upregulating EMX2.
Wei XF, Chen QL, Fu Y, Zhang QK. | 07/11/2020 |
| Results identify the EMX2 mRNA as a major miss-spliced down stream target of SNRPE with heterozygous missense mutation causing microcephaly. | A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing.
Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W., Free PMC Article | 02/1/2020 |
| In the three variants of papillary thyroid cancer (PTC), EMX2 was significantly downregulated in classical PTC, while EMX2OS was significantly downregulated in follicular and classical PTC, compared with adjacent normal tissues. Kaplan-Meier survival curves showed that EMX2 and EMX2OS expression was not related to relapse-free survival in follicular PTC. | The downregulation of lncRNA EMX2OS might independently predict shorter recurrence-free survival of classical papillary thyroid cancer.
Gu Y, Feng C, Liu T, Zhang B, Yang L., Free PMC Article | 06/1/2019 |
| EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. | EMX2 gene expression predicts liver metastasis and survival in colorectal cancer.
Aykut B, Ochs M, Radhakrishnan P, Brill A, Höcker H, Schwarz S, Weissinger D, Kehm R, Kulu Y, Ulrich A, Schneider M., Free PMC Article | 05/5/2018 |
| Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences. | Emx2 as a novel tool to suppress glioblastoma.
Falcone C, Daga A, Leanza G, Mallamaci A., Free PMC Article | 01/13/2018 |
| EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells. | Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells.
Zhang Y, Cao G, Yuan QG, Li JH, Yang WB., Free PMC Article | 11/4/2017 |
| EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration. | EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas.
Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E, Woodard GA, Hao X, Wang C, Jablons DM, He B., Free PMC Article | 05/14/2016 |
| Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion. | Nonsense mutation of EMX2 is potential causative for uterus didelphysis: first molecular explanation for isolated incomplete müllerian fusion.
Liu S, Gao X, Qin Y, Liu W, Huang T, Ma J, Simpson JL, Chen ZJ. | 03/5/2016 |
| Deletions of EMX2 have been associated with a wide range of DSD. | Severe sex differentiation disorder in a boy with a 3.8 Mb 10q25.3-q26.12 microdeletion encompassing EMX2.
Piard J, Mignot B, Arbez-Gindre F, Aubert D, Morel Y, Roze V, McElreavy K, Jonveaux P, Valduga M, Van Maldergem L. | 06/6/2015 |
| EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival. | The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma.
Giroux Leprieur E, Hirata T, Mo M, Chen Z, Okamoto J, Clement G, Li H, Wislez M, Jablons DM, He B. | 05/16/2015 |
| downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer | EMX2 is downregulated in endometrial cancer and correlated with tumor progression.
Qiu H, Yan Q, Luo X, Zhang H, Bao W, Wan X. | 08/3/2013 |
| EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo. | Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer.
Li J, Mo M, Chen Z, Chen Z, Sheng Q, Mu H, Zhang F, Zhang Y, Zhi XY, Li H, He B, Zhou HM., Free PMC Article | 03/9/2013 |
| Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay. | Rare somatic mutation and loss of expression of EMX2 gene in common solid cancers.
Kim MS, An CH, Yoo NJ, Lee SH. | 12/10/2011 |
| Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma. | Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.
Okamoto J, Kratz JR, Hirata T, Mikami I, Raz D, Segal M, Chen Z, Zhou HM, Pham P, Li H, Yagui-Beltran A, Ray MR, Koizumi K, Shimizu K, Jablons D, He B., Free PMC Article | 10/29/2011 |
| Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. | Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter.
Beckmann J, Vitobello A, Ferralli J, Kenzelmann Brož D, Rijli FM, Chiquet-Ehrismann R., Free PMC Article | 09/24/2011 |
| promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes | EMX2 is epigenetically silenced and suppresses growth in human lung cancer.
Okamoto J, Hirata T, Chen Z, Zhou HM, Mikami I, Li H, Yagui-Beltran A, Johansson M, Coussens LM, Clement G, Shi Y, Zhang F, Koizumi K, Shimizu K, Jablons D, He B., Free PMC Article | 11/27/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.
Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. | 04/7/2010 |
| These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents. | Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development.
Bayatti N, Sarma S, Shaw C, Eyre JA, Vouyiouklis DA, Lindsay S, Clowry GJ., Free PMC Article | 01/21/2010 |
| provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations | No major role for the EMX2 gene in schizencephaly.
Merello E, Swanson E, De Marco P, Akhter M, Striano P, Rossi A, Cama A, Leventer RJ, Guerrini R, Capra V, Dobyns WB. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Variants in EMX2 and PTEN do not contribute to risk of endometriosis.
Treloar SA, Zhao ZZ, Le L, Zondervan KT, Martin NG, Kennedy S, Nyholt DR, Montgomery GW. | 03/13/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | Comprehensive EMX2 genotyping of a large schizencephaly case series.
Tietjen I, Bodell A, Apse K, Mendonza AM, Chang BS, Shaw GM, Barkovich AJ, Lammer EJ, Walsh CA. | 03/13/2008 |