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    EMP1 epithelial membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 2012, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    EMP1 correlated with cancer progression and immune characteristics in pan-cancer and ovarian cancer.

    EMP1 correlated with cancer progression and immune characteristics in pan-cancer and ovarian cancer.
    Zhang J, Yang J, Li X, Mao L, Zhang Y, Liu Y, Bao Y.

    07/5/2024
    Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.

    Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
    Zhou T, Chen H, Wang Y, Wen S, Dao P, Chen M.

    07/17/2023
    Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis.

    Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis.
    Zeng Q, Yi C, Lu J, Wang X, Chen K, Hong L., Free PMC Article

    05/3/2023
    Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling.

    Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling.
    Liu S, Shi J, Wang L, Huang Y, Zhao B, Ding H, Liu Y, Wang W, Chen Z, Yang J.

    08/27/2022
    Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer.

    Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer.
    Wang Y, Zhang L, Yao C, Ma Y, Liu Y., Free PMC Article

    04/30/2022
    Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.

    Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
    Kim EK, Koo JS.

    04/9/2022
    Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma.

    Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma.
    Li X, Yan L, Xue H.

    01/22/2022
    EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis.

    EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis.
    Wang M, Liu T, Hu X, Yin A, Liu J, Wang X.

    11/13/2021
    Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.

    Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
    Sato A, Rahman NIA, Shimizu A, Ogita H., Free PMC Article

    10/9/2021
    Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.

    Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.
    Ma Y, Schröder DC, Nenkov M, Rizwan MN, Abubrig M, Sonnemann J, Murrieta-Coxca JM, Morales-Prieto DM, Westermann M, Gaßler N, Chen Y., Free PMC Article

    05/1/2021
    Circ100284 promotes invasion and migration of osteosarcoma cells by down-regulating PTEN and EMP1.

    Circ100284 promotes invasion and migration of osteosarcoma cells by down-regulating PTEN and EMP1.
    Liu YD, Liu LP.

    04/17/2021
    MIR31HG exhibits oncogenic property and acts as a sponge for miR-361-3p in cervical carcinoma.

    MIR31HG exhibits oncogenic property and acts as a sponge for miR-361-3p in cervical carcinoma.
    Li Y.

    02/13/2021
    EMP1 regulates cell proliferation, migration, and stemness in gliomas through PI3K-AKT signaling and CD44.

    EMP1 regulates cell proliferation, migration, and stemness in gliomas through PI3K-AKT signaling and CD44.
    Wang J, Li X, Wu H, Wang H, Yao L, Deng Z, Zhou Y.

    09/19/2020
    High EMP1 expression is associated with glioblastoma progression.

    Epithelial membrane protein 1 promotes glioblastoma progression through the PI3K/AKT/mTOR signaling pathway.
    Miao L, Jiang Z, Wang J, Yang N, Qi Q, Zhou W, Feng Z, Li W, Zhang Q, Huang B, Chen A, Zhang D, Zhao P, Li X., Free PMC Article

    01/25/2020
    upregulation of EMP1 significantly increases cancer cell migration that leads to tumor metastasis

    Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.
    Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H., Free PMC Article

    02/23/2019
    The abnormal expression of EMP-1 may be associated with progression of laryngeal carcinoma (LC) and the gene may act as a prognostic marker for LC.

    The Prognostic Value of Epithelial Membrane Protein 1 (EMP-1) in Patients with Laryngeal Carcinoma.
    Liu C, Wei X, Li F, Wang L, Ruan X, Jia J, Zhang X., Free PMC Article

    04/28/2018
    The studies implicating GAS3 protein family (EMP1, EMP2, EMP3 and PMP22) in cancer pathogenesis as well as probe the structural similarities between the family members were highlighted.

    Review of the GAS3 Family of Proteins and their Relevance to Cancer.
    Ashki N, Gordon L, Wadehra M., Free PMC Article

    02/3/2018
    Therefore, EMP1 is a tumor suppressor in laryngeal carcinoma. Boosting EMP1 expression in laryngeal carcinoma initiates multiple anticancer phenotypes and thus presents a promising therapeutic strategy for laryngeal cancer.

    The expression and function of epithelial membrane protein 1 in laryngeal carcinoma.
    Li H, Zhang X, Jiang X, Ji X.

    04/8/2017
    SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.EMP1 localises to tight junctions and is essential for their formation and function.

    SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.
    Durgan J, Tao G, Walters MS, Florey O, Schmidt A, Arbelaez V, Rosen N, Crystal RG, Hall A., Free PMC Article

    08/1/2015
    Low EMP1 expression in colorectal cancer is associated with increased disease severity, suggesting that EMP1 may be a negative regulator of colorectal cancer

    Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma.
    Sun GG, Wang YD, Cui DW, Cheng YJ, Hu WN., Free PMC Article

    04/18/2015
    Results demonstrated that EMP1 protein levels were significantly reduced in gastric carcinoma and were associated with tumor invasion, lymph node metastasis, clinical stage and cell differentiation.

    Association of EMP1 with gastric carcinoma invasion, survival and prognosis.
    Sun G, Zhao G, Lu Y, Wang Y, Yang C.

    02/28/2015
    EMP1 as an independent predictor for poor outcome in precursor-B ALL (BCP-ALL) (P=0.004, hazard ratio: 2.36 (1.31-4.25).

    EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion.
    Ariës IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R, den Boer ML.

    11/8/2014
    EMP-1 was significantly up-regulated in NSCLC patients.

    EMP-1 promotes tumorigenesis of NSCLC through PI3K/AKT pathway.
    Lai S, Wang G, Cao X, Li Z, Hu J, Wang J.

    09/13/2014
    EMP1 expression decreased in prostate cancer and correlated significantly T stages, lymph node metastasis, clinic stage, and Gleason score

    EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate cancer cell proliferation and invasion.
    Sun GG, Wang YD, Cui DW, Cheng YJ, Hu WN.

    06/14/2014
    EMP1 may play important roles as a negative regulator to nasopharyngeal cancer cell.

    EMP1 inhibits nasopharyngeal cancer cell growth and metastasis through induction apoptosis and angiogenesis.
    Sun GG, Lu YF, Fu ZZ, Cheng YJ, Hu WN.

    06/14/2014
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