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    ELN elastin [ Homo sapiens (human) ]

    Gene ID: 2006, updated on 16-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TGF-alpha/EGFR signaling promotes lipopolysaccharide-induced abnormal elastin deposition and alveolar simplification.

    TGF-α/EGFR signaling promotes lipopolysaccharide-induced abnormal elastin deposition and alveolar simplification.
    Li J, Cao J, Yan C, Gong X.

    04/12/2024
    Elastin recoil is driven by the hydrophobic effect.

    Elastin recoil is driven by the hydrophobic effect.
    Jamhawi NM, Koder RL, Wittebort RJ.,

    03/14/2024
    Single Nucleotide Polymorphisms Mutation of Tropoelastin Gene Affects Tropoelastin mRNA and Elastin Expressions in Human Aortic Smooth Muscle Cells.

    Single Nucleotide Polymorphisms Mutation of Tropoelastin Gene Affects Tropoelastin mRNA and Elastin Expressions in Human Aortic Smooth Muscle Cells.
    Yue J, Qi YF, Zhang WB, Liu SH, Chen H, Li ZZ, Wu HF.

    12/20/2023
    Configuration of elastin fibers in the intra- and extra-capsule ligaments of the elderly cricoarytenoid joint.

    Configuration of elastin fibers in the intra- and extra-capsule ligaments of the elderly cricoarytenoid joint.
    Wang Q, Li S, Wang H, Zhang M., Free PMC Article

    08/2/2023
    Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease.

    Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease.
    Kucherenko MM, Sang P, Yao J, Gransar T, Dhital S, Grune J, Simmons S, Michalick L, Wulsten D, Thiele M, Shomroni O, Hennig F, Yeter R, Solowjowa N, Salinas G, Duda GN, Falk V, Vyavahare NR, Kuebler WM, Knosalla C., Free PMC Article

    07/25/2023
    Assessment of fibrillin-2 and elastin gene polymorphisms in patients with a traumatic Achilles tendon rupture: Is Achilles tendon rupture a genetic disease?

    Assessment of fibrillin-2 and elastin gene polymorphisms in patients with a traumatic Achilles tendon rupture: Is Achilles tendon rupture a genetic disease?
    Poszepczyński J, Pietrusiński M, Borowiec M, Edward Domżalski M.

    05/17/2023
    Autosomal dominant cutis laxa and critical stenosis of the left main coronary artery in a 21-year-old female with an intronic mutation in the elastin gene.

    Autosomal dominant cutis laxa and critical stenosis of the left main coronary artery in a 21-year-old female with an intronic mutation in the elastin gene.
    Krarup NT, Hvidbjerg M, Zaremba T, Sommerlund M, Christensen MK.

    04/12/2023
    Mechanical Properties and Functions of Elastin: An Overview.

    Mechanical Properties and Functions of Elastin: An Overview.
    Trębacz H, Barzycka A., Free PMC Article

    04/5/2023
    Effect of the elastin-derived peptides (VGVAPG and VVGPGA) on breast (MCF-7) and lung (A549) cancer cell lines in vitro.

    Effect of the elastin-derived peptides (VGVAPG and VVGPGA) on breast (MCF-7) and lung (A549) cancer cell lines in vitro.
    Szychowski KA, Skóra B, Pomianek T.

    07/2/2022
    Degeneration of the lumbar spine and its relation to the expression of collagen and elastin in facet joint capsules and ligament flavum.

    Degeneration of the lumbar spine and its relation to the expression of collagen and elastin in facet joint capsules and ligament flavum.
    Voelker A, Schroeter F, Steinke H, Heyde CE., Free PMC Article

    06/25/2022
    Research on the expression of elastin in the conjoint fascial sheath for the correction of severe unilateral congenital blepharoptosis.

    Research on the expression of elastin in the conjoint fascial sheath for the correction of severe unilateral congenital blepharoptosis.
    Liu Z, Jia X, Pang R, Wang H, Shi J, Bai P., Free PMC Article

    06/18/2022
    Routine Elastin Staining in Surgically Resected Colorectal Cancer: Impact on Venous Invasion Detection and its Association With Oncologic Outcomes.

    Routine Elastin Staining in Surgically Resected Colorectal Cancer: Impact on Venous Invasion Detection and its Association With Oncologic Outcomes.
    Sari A, Cyr DP, Brar A, Messenger DE, Driman DK, Shivji S, Assarzadegan N, Juda A, Swallow CJ, Kennedy ED, Brar MS, Conner J, Kirsch R.

    02/19/2022
    Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias.

    Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias.
    Hikino K, Koido M, Tomizuka K, Liu X, Momozawa Y, Morisaki T, Murakami Y, The Biobank Japan Project, Mushiroda T, Terao C., Free PMC Article

    01/15/2022
    Identification and characterization of a novel ELN mutation in congenital heart disease with pulmonary artery stenosis.

    Identification and characterization of a novel ELN mutation in congenital heart disease with pulmonary artery stenosis.
    Hou C, Zheng J, Liu W, Xie L, Sun X, Zhang Y, Xu M, Li Y, Xiao T., Free PMC Article

    11/6/2021
    The evolutionary background and functional consequences of the rs2071307 polymorphism in human tropoelastin.

    The evolutionary background and functional consequences of the rs2071307 polymorphism in human tropoelastin.
    Reichheld SE, Muiznieks LD, Huynh Q, Wang N, Ing C, Miao M, Sitarz EE, Pomès R, Sharpe S, Keeley FW.

    10/9/2021
    Domains 12 to 16 of tropoelastin promote cell attachment and spreading through interactions with glycosaminoglycan and integrins alphaV and alpha5beta1.

    Domains 12 to 16 of tropoelastin promote cell attachment and spreading through interactions with glycosaminoglycan and integrins alphaV and alpha5beta1.
    Bochicchio B, Yeo GC, Lee P, Emul D, Pepe A, Laezza A, Ciarfaglia N, Quaglino D, Weiss AS.

    08/7/2021
    Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia.

    Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia.
    Vaikari VP, Park M, Keossayan L, MacKay JA, Alachkar H., Free PMC Article

    07/10/2021
    Atypical 7q11.23 deletions excluding ELN gene result in Williams-Beuren syndrome craniofacial features and neurocognitive profile.

    Atypical 7q11.23 deletions excluding ELN gene result in Williams-Beuren syndrome craniofacial features and neurocognitive profile.
    Alesi V, Loddo S, Orlando V, Genovese S, Di Tommaso S, Liambo MT, Pompili D, Ferretti D, Calacci C, Catino G, Falasca R, Dentici ML, Novelli A, Digilio MC, Dallapiccola B.

    07/3/2021
    Transglutaminase-Mediated Cross-Linking of Tropoelastin to Fibrillin Stabilises the Elastin Precursor Prior to Elastic Fibre Assembly.

    Transglutaminase-Mediated Cross-Linking of Tropoelastin to Fibrillin Stabilises the Elastin Precursor Prior to Elastic Fibre Assembly.
    Lockhart-Cairns MP, Newandee H, Thomson J, Weiss AS, Baldock C, Tarakanova A., Free PMC Article

    03/6/2021
    Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease.

    Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease.
    Chang CJ, Huang CC, Chen PR, Lai YJ., Free PMC Article

    02/27/2021
    Elastin is a key factor of tumor development in colorectal cancer.

    Elastin is a key factor of tumor development in colorectal cancer.
    Li J, Xu X, Jiang Y, Hansbro NG, Hansbro PM, Xu J, Liu G., Free PMC Article

    11/28/2020
    Elastin in the Tumor Microenvironment.

    Elastin in the Tumor Microenvironment.
    Wang Y, Song EC, Resnick MB.

    10/24/2020
    Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.

    Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.
    Panwar P, Hedtke T, Heinz A, Andrault PM, Hoehenwarter W, Granville DJ, Schmelzer CEH, Brömme D.

    10/24/2020
    report demonstrates that the affected arteries, severities, and clinical course of supravalvular aortic stenosis can be variable among family members with the same ELN mutation

    Novel ELN mutation in a Japanese family with a severe form of supravalvular aortic stenosis.
    Sugiyama K, Horigome H, Lin L, Murakami T, Shiono J, Yamashiro Y, Matsuura H, Yoda H, Yanagisawa H., Free PMC Article

    07/4/2020
    While monomeric tropoelastin has the intrinsic ability to self-assemble into fibrills, its in vivo assembly is guided by interactions with cells and other matrix-associated components. In addition, the multiplicity of reported mRNA isoforms, if translated into protein variants, could modulate not only interactions with these matrix-associated components but also self-assembly and functional properties. [review]

    Sequence variants of human tropoelastin affecting assembly, structural characteristics and functional properties of polymeric elastin in health and disease.
    Reichheld SE, Muiznieks LD, Lu R, Sharpe S, Keeley FW.

    07/4/2020
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