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    ELF1 E74 like ETS transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 1997, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.

    ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
    Zhu P, Dou C, Song Z, Bi X, Wu X, Miao Y.

    08/31/2023
    ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.

    ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
    Zhao L, Wu X, Zhang Z, Fang L, Yang B, Li Y., Free PMC Article

    06/5/2023
    Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2.

    Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2.
    Han D, Li X, Cheng Y.

    03/21/2023
    ELF1 Transcription Factor Enhances the Progression of Glioma via ATF5 promoter.

    ELF1 Transcription Factor Enhances the Progression of Glioma via ATF5 promoter.
    Hu M, Li H, Xie H, Fan M, Wang J, Zhang N, Ma J, Che S.

    08/28/2021
    Transcriptomic Analysis of Naive Human Embryonic Stem Cells Cultured in Three-Dimensional PEG Scaffolds.

    Transcriptomic Analysis of Naïve Human Embryonic Stem Cells Cultured in Three-Dimensional PEG Scaffolds.
    McKee C, Brown C, Bakshi S, Walker K, Govind CK, Chaudhry GR., Free PMC Article

    06/26/2021
    ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression.

    ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression.
    Wang L, Tang D, Wu T, Sun F., Free PMC Article

    04/24/2021
    ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway.

    ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway.
    Xiao XH, He SY.

    03/20/2021
    We demonstrate that expression of ELF1 is impaired in cHL through genetic and epigenetic alterations, and thus, it may represent an additional member of a TF network whose downregulation contributes to the loss of B-cell phenotype of HRS cells.

    Expression of ELF1, a lymphoid ETS domain-containing transcription factor, is recurrently lost in classical Hodgkin lymphoma.
    Paczkowska J, Soloch N, Bodnar M, Kiwerska K, Janiszewska J, Vogt J, Domanowska E, Martin-Subero JI, Ammerpohl O, Klapper W, Marszalek A, Siebert R, Giefing M.

    02/22/2020
    ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region.

    An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations.
    Makowski MM, Willems E, Fang J, Choi J, Zhang T, Jansen PW, Brown KM, Vermeulen M.

    10/29/2016
    ELF-1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation.

    The hematopoietic regulator, ELF-1, enhances the transcriptional response to Interferon-β of the OAS1 anti-viral gene.
    Larsen S, Kawamoto S, Tanuma S, Uchiumi F., Free PMC Article

    10/22/2016
    Data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients.

    Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome.
    Gerloff A, Dittmer A, Oerlecke I, Holzhausen HJ, Dittmer J.

    03/3/2012
    Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells.

    Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.
    Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T., Free PMC Article

    03/3/2012
    The expression of Elf-1 and survivin in non-small cell lung cancer is related to differentiation, lymphatic metastasis, clinical stage, and prognosis, and both are positively correlated with microvessel density.

    Expression of Elf-1 and survivin in non-small cell lung cancer and their relationship to intratumoral microvessel density.
    Yang DX, Li NE, Ma Y, Han YC, Shi Y.

    02/18/2012
    the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in intestinal epithelial cells.

    Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1.
    Sugi Y, Takahashi K, Nakano K, Hosono A, Kaminogawa S.

    11/26/2011
    through a genome-wide association in a Hong Kong Chinese cohort and replication in 2 other Asian populations, identified association of ELF1 with systemic lupus erythematosus

    ELF1 is associated with systemic lupus erythematosus in Asian populations.
    Yang J, Yang W, Hirankarn N, Ye DQ, Zhang Y, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Baum L, Kwan P, Lee TL, Ho MH, Lee PP, Wong WH, Zeng S, Zhang J, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL, Yang J, Yang W, Hirankarn N, Ye DQ, Zhang Y, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Baum L, Kwan P, Lee TL, Ho MH, Lee PP, Wong WH, Zeng S, Zhang J, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL.

    07/23/2011
    The expression levels of both Elf-1 and VEGF were significantly related with tumor differentiation, lymphatic metastasis, clinical stage, and postoperative survival time in non-small cell lung cancer.

    [Expression and significance of Elf-1 and vascular endothelial growth factor in non-small cell lung cancer].
    Yang DX, Han YC, Liu LY, Yu N, Wang X, Shi Y.

    07/16/2011
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    ELF1 is associated with systemic lupus erythematosus in Asian populations.
    Yang J, Yang W, Hirankarn N, Ye DQ, Zhang Y, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Baum L, Kwan P, Lee TL, Ho MH, Lee PP, Wong WH, Zeng S, Zhang J, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL, Yang J, Yang W, Hirankarn N, Ye DQ, Zhang Y, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Baum L, Kwan P, Lee TL, Ho MH, Lee PP, Wong WH, Zeng S, Zhang J, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL.

    12/5/2010
    ETS transcription factor ELF1 is an important positive regulator of MEIS1 expression

    Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1.
    Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK., Free PMC Article

    09/13/2010
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Data show that VEGFR1 promoter binding sites for ELF-1, CREB and EGR-1/3 play a positive role in gene transcription in endothelial cells.

    Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.
    Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, Yano K, Janes L, Beeler D, Spokes KC, Li D, Regan E, Shih SC, Oettgen P, Minami T, Aird WC., Free PMC Article

    02/15/2010
    Includes a comparison of MEF to ELF1.

    Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.
    Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD., Free PMC Article

    02/20/2009
    aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231, resulting in limited expression and binding of the 98 kDa Elf-1 form to the CD3zeta and FcRgamma promoters.

    PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells.
    Juang YT, Wang Y, Jiang G, Peng HB, Ergin S, Finnell M, Magilavy A, Kyttaris VC, Tsokos GC., Free PMC Article

    01/21/2010
    Elf-1 in combination with Sp1 and GABP reduced FcRgamma promoter activity.

    Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1.
    Takahashi K, Hayashi N, Shimokawa T, Umehara N, Kaminogawa S, Ra C., Free PMC Article

    01/21/2010
    These results provide new evidence that Elf-1 is involved in transcriptional activation of hPygo2.

    Oncogenic activation of the human Pygopus2 promoter by E74-like factor-1.
    Andrews PG, Kennedy MW, Popadiuk CM, Kao KR.

    01/21/2010
    transcriptional regulation of the LAT gene, including the discovery that the Ets transcription factor Elf-1 may play a central role in its expression

    Regulation of the human LAT gene by the Elf-1 transcription factor.
    Finco TS, Justice-Healy GE, Patel SJ, Hamilton VE., Free PMC Article

    01/21/2010
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