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    AIF1 allograft inflammatory factor 1 [ Homo sapiens (human) ]

    Gene ID: 199, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis.

    Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis.
    Chen L, Zhao Y, Li M, Lv G.

    04/17/2024
    Identification of allograft inflammatory factor-1 suppressing the progression and indicating good prognosis of osteosarcoma.

    Identification of allograft inflammatory factor-1 suppressing the progression and indicating good prognosis of osteosarcoma.
    Liu W, Shi T, Zheng D, Ke G, Chen J., Free PMC Article

    04/17/2024
    Allograft inflammatory factor 1 is a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.

    Allograft inflammatory factor 1 is a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.
    Liu X, Zhang D, Hu J, Xu S, Xu C, Shen Y., Free PMC Article

    04/26/2023
    Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1.

    Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1.
    Chinnasamy P, Casimiro I, Riascos-Bernal DF, Venkatesh S, Parikh D, Maira A, Srinivasan A, Zheng W, Tarabra E, Zong H, Jayakumar S, Jeganathan V, Pradan K, Aleman JO, Singh R, Nandi S, Pessin JE, Sibinga NES., Free PMC Article

    03/9/2023
    AIF-1, a potential biomarker of aggressive tumor behavior in patients with non-small cell lung cancer.

    AIF-1, a potential biomarker of aggressive tumor behavior in patients with non-small cell lung cancer.
    Wang L, Zhao X, Zheng H, Zhu C, Liu Y., Free PMC Article

    12/24/2022
    The Effect of Allograft Inflammatory Factor-1 on Inflammation, Oxidative Stress, and Autophagy via miR-34a/ATG4B Pathway in Diabetic Kidney Disease.

    The Effect of Allograft Inflammatory Factor-1 on Inflammation, Oxidative Stress, and Autophagy via miR-34a/ATG4B Pathway in Diabetic Kidney Disease.
    Jianbing H, Xiaotian L, Jie T, Xueying C, Honge J, Bo Z, Lirong H, Lei Z., Free PMC Article

    11/12/2022
    Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study.

    Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study.
    Trotta MC, Gesualdo C, Petrillo F, Cavasso G, Corte AD, D'Amico G, Hermenean A, Simonelli F, Rossi S., Free PMC Article

    07/23/2022
    The Novel Tumor Microenvironment-Related Prognostic Gene AIF1 May Influence Immune Infiltrates and is Correlated with TIGIT in Esophageal Cancer.

    The Novel Tumor Microenvironment-Related Prognostic Gene AIF1 May Influence Immune Infiltrates and is Correlated with TIGIT in Esophageal Cancer.
    Xu X, Wang D, Li N, Sheng J, Xie M, Zhou Z, Cheng G, Fan Y.

    07/16/2022
    Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients.

    Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients.
    Castrogiovanni P, Sanfilippo C, Imbesi R, Maugeri G, Lo Furno D, Tibullo D, Castorina A, Musumeci G, Di Rosa M., Free PMC Article

    10/23/2021
    The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-kappaB Pathway in Uremia.

    The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-κB Pathway in Uremia.
    Hao J, Tang J, Zhang L, Li X, Hao L., Free PMC Article

    09/11/2021
    Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid Arthritis.

    Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid Arthritis.
    Piotrowska K, Słuczanowska-Głabowska S, Kurzawski M, Dziedziejko V, Kopytko P, Paczkowska E, Rogińska D, Safranow K, Machaliński B, Pawlik A., Free PMC Article

    02/13/2021
    Study reports on a novel type of microglia pathological change, i.e. localized loss of IBA1 that is linked, at least in part, to obesity and hepatic dysfunction.

    Loss of IBA1-Expression in brains from individuals with obesity and hepatic dysfunction.
    Lier J, Winter K, Bleher J, Grammig J, Mueller WC, Streit W, Bechmann I.

    06/27/2020
    A prominent feature of age-associated deep subcortical white matter lesions was a population of Iba-1-/CD68+ microglia. Overall the study shows significant differences in the immunoreactive profile of microglial markers.

    Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions.
    Waller R, Baxter L, Fillingham DJ, Coelho S, Pozo JM, Mozumder M, Frangi AF, Ince PG, Simpson JE, Highley JR., Free PMC Article

    11/2/2019
    AIF-1 gene does not confer susceptibility to Behcet's disease: Analysis of extended haplotypes in Sardinian population

    AIF-1 gene does not confer susceptibility to Behçet's disease: Analysis of extended haplotypes in Sardinian population.
    Angioni MM, Piga M, Paladini F, Lai S, Erre GL, Floris A, Cauli A, Fiorillo MT, Passiu G, Carcassi C, Sorrentino R, Mathieu A., Free PMC Article

    03/2/2019
    Small interfering RNA (siRNA)-mediated silencing of AIF-1 expression resulted in a reduction in cell proliferation and migration in human HCC cells.

    Expression of Allograft Inflammatory Factor-1 (AIF-1) in Hepatocellular Carcinoma.
    Zhang Q, Sun S, Zhu C, Xie F, Cai Q, Sun H, Chen G, Liang X, Xie H, Shi J, Liao Y, Zhou J., Free PMC Article

    12/22/2018
    It may be speculated that Iba-1 protein besides its major function (involvement in phagocytosis) can perform the role of a transcriptional factor.

    [INTRANUCLEAR ACCUMULATION OF Iba-1 PROTEIN IN MICROGLIOCYTES OF THE HUMAN BRAIN].
    Korzhevskiy DE, Kirik OV, Alekseyeva OS, Sukhorukova YG, Syrtsova MA.

    09/15/2018
    This study shown the AIF1 expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.

    Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain.
    Wilhelmsson U, Andersson D, de Pablo Y, Pekny R, Ståhlberg A, Mulder J, Mitsios N, Hortobágyi T, Pekny M, Pekna M.

    03/24/2018
    involved in the immunological process underlying rheumatoid arthritis

    Expression of allograft inflammatory factor-1 in peripheral blood monocytes and synovial membranes in patients with rheumatoid arthritis.
    Pawlik A, Kotrych D, Paczkowska E, Roginska D, Dziedziejko V, Safranow K, Machalinski B.

    11/12/2016
    Using double labeling with Iba-1 and cd68 could determine the physiological state of microglia in brain contusion based on their morphology and immunoreactivity.

    Visualisation of Microglia with the use of Immunohistochemical Double Staining Method for CD-68 and Iba-1 of Cerebral Tissue Samples in Cases of Brain Contusions.
    Stankov A, Belakaposka-Srpanova V, Bitoljanu N, Cakar L, Cakar Z, Rosoklija G.

    09/3/2016
    The results of our study suggest that the AIF1 gene polymorphisms have no influence on long-term kidney allograft function.

    Influence of AIF1 Gene Polymorphisms on Long-Term Kidney Allograft Function.
    Romanowski M, Kłoda K, Milczarek S, Pawlik A, Domański L, Safranow K, Ciechanowski K.

    07/2/2016
    Data showed that AIF-1 promoted the proliferation of HepG2 cells by accelerating the activation of IGF-1R and its downstream signaling pathway, which confirms that AIF-1 plays a crucial role in the development of hepatocellular carcinoma cells.

    Daintain/AIF-1 accelerates the activation of insulin-like growth factor-1 receptor signaling pathway in HepG2 cells.
    Jia S, Du Z, Jiang H, Huang X, Chen Z, Chen N.

    04/2/2016
    AIF-1 functions as a tumor suppressor possibly by regulating beta-catenin in gastric cancer. the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.

    Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer.
    Ye Y, Miao S, Lu R, Xia X, Chen Y, Zhang J, Wu X, He S, Qiang F, Zhou J.

    09/6/2014
    AIF-1, which induced chemokines and enhanced chemotaxis of monocytes, may represent a molecular target for the therapy of immune-inflammatory disorders

    Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells.
    Kadoya M, Yamamoto A, Hamaguchi M, Obayashi H, Mizushima K, Ohta M, Seno T, Oda R, Fujiwara H, Kohno M, Kawahito Y.

    08/23/2014
    The results of this study suggest a lack of association between AIF-1 gene polymorphisms and response to sulphasalazine treatment in rheumatoid arthritis.

    [Association between AIF-1 gene polymorphisms and response to rheumatoid arthritis treatment with sulphasalazine].
    Dabrowska-Zamojcin E, Herczyńska MM, Pawlik A.

    08/16/2014
    The results of this study suggest that the patients with the rs2259571 CC AIF1 genotype have a poorer response to therapy with Methotrexate.

    Effect of allograft inflammatory factor-1 gene polymorphisms on rheumatoid arthritis treatment with methotrexate.
    Pawlik A, Herczynska MM, Dziedziejko V, Malinowski D, Kurzawski M, Drozdzik M, Gawronska-Szklarz B.

    05/3/2014
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