| RORgammat up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire. | RORγt up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire.
Naik AK, Dauphars DJ, Corbett E, Simpson L, Schatz DG, Krangel MS., Free PMC Article | 07/16/2024 |
| Retinoid orphan receptor gamma t (rorgammat) promotes inflammatory eosinophilia but is dispensable for innate immune-mediated colitis. | Retinoid orphan receptor gamma t (rorγt) promotes inflammatory eosinophilia but is dispensable for innate immune-mediated colitis.
Torres-Huerta A, Ruley-Haase K, Reed T, Boger-May A, Rubadeux D, Mayer L, Rajashekara AM, Hiller M, Frech M, Roncagli C, Pedersen C, Camacho MC, Hollmer L, English L, Kane G, Boone DL., Free PMC Article | 07/15/2024 |
| Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORgammat. | Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt.
Erice PA, Huang X, Seasock MJ, Robertson MJ, Tung HY, Perez-Negron MA, Lotlikar SL, Corry DB, Kheradmand F, Rodriguez A., Free PMC Article | 06/7/2024 |
| RORgammat[+] c-Maf[+] Vgamma4[+] gammadelta T cells are generated in the adult thymus but do not reach the periphery. | RORγt(+) c-Maf(+) Vγ4(+) γδ T cells are generated in the adult thymus but do not reach the periphery.
Yang T, Barros-Martins J, Wang Z, Wencker M, Zhang J, Smout J, Gambhir P, Janssen A, Schimrock A, Georgiev H, León-Lara X, Weiss S, Huehn J, Prinz I, Krueger A, Foerster R, Walzer T, Ravens S. | 12/5/2023 |
| A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells. | A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells.
Chang D, Zhang H, Ge J, Xing Q, Guo X, Wang X, Dong C., Free PMC Article | 03/31/2023 |
| Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis. | Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis.
Luo C, Luo F, Che L, Zhang H, Zhao L, Zhang W, Man X, Bu Q, Luan H, Zhou B, Zhou H, Xu Y., Free PMC Article | 03/10/2023 |
| Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis. | Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis.
Yang WL, Qiu W, Zhang T, Xu K, Gu ZJ, Zhou Y, Xu HJ, Yang ZZ, Shen B, Zhao YL, Zhou Q, Yang Y, Li W, Yang PY, Yang YG., Free PMC Article | 02/23/2023 |
| RORgammat-Expressing Pathogenic CD4(+) T Cells Cause Brain Inflammation during Chronic Colitis. | RORγt-Expressing Pathogenic CD4(+) T Cells Cause Brain Inflammation during Chronic Colitis.
Mickael ME, Bhaumik S, Chakraborti A, Umfress AA, van Groen T, Macaluso M, Totenhagen J, Sorace AG, Bibb JA, Standaert DG, Basu R., Free PMC Article | 07/23/2022 |
| RORgammat phosphorylation protects against T cell-mediated inflammation. | RORγt phosphorylation protects against T cell-mediated inflammation.
Ma S, Patel SA, Abe Y, Chen N, Patel PR, Cho BS, Abbasi N, Zeng S, Schnabl B, Chang JT, Huang WJM., Free PMC Article | 04/16/2022 |
| T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORgammat expression and function. | T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORγt expression and function.
Shimizu M, Kondo Y, Tanimura R, Furuyama K, Yokosawa M, Asashima H, Tsuboi H, Matsumoto I, Sumida T., Free PMC Article | 12/11/2021 |
| Effects of RORgammat overexpression on the murine central nervous system. | Effects of RORγt overexpression on the murine central nervous system.
Sasaki T, Nagata R, Takahashi S, Takei Y., Free PMC Article | 11/13/2021 |
| The effects of the miR-21/SMAD7/TGF-beta pathway on Th17 cell differentiation in COPD. | The effects of the miR-21/SMAD7/TGF-β pathway on Th17 cell differentiation in COPD.
He S, Sun S, Lu J, Chen L, Mei X, Li L, Zeng Z, Zhong M, Xie L., Free PMC Article | 10/16/2021 |
| The role of RORgammat at maternal-fetal interface during murine pregnancy. | The role of RORγt at maternal-fetal interface during murine pregnancy.
Li Y, Lopez GE, Lindner PN, Parrella L, Larson M, Sun Y, Stanic AK., Free PMC Article | 07/10/2021 |
| Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORgammat Signaling Pathways in Asthmatic Mice. | Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice.
Kim SH, Hong JH, Yang WK, Kim HJ, An HJ, Lee YC., Free PMC Article | 05/15/2021 |
| CD4+ Tconv cells can differentiate into both RORgamma+ and Helios+ pTreg cells. | Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.
Pratama A, Schnell A, Mathis D, Benoist C., Free PMC Article | 07/18/2020 |
| Study reveals REV-ERBalpha as an antagonist of RORgammat. REV-ERBalpha and RORgammat share the same DNA binding motif. REV-ERB can inhibit the expression of RORgammat target genes and suppress RORgammat-driven Th17 cell differentiation. Treatment with a synthetic REV-ERB agonist delays the onset and impedes the progression of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. | The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease.
Chang C, Loo CS, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y., Free PMC Article | 04/11/2020 |
| Regulated the mRNA and protein expression levels of IL-17A, RORgammaT, IL-22, T-bet, STAT3, pSTAT-3, IL-10, and Foxp3 in the brain tissue. | The histamine-4 receptor antagonist JNJ7777120 prevents immune abnormalities by inhibiting RORγt/T-bet transcription factor signaling pathways in BTBR T(+) Itpr3(tf)/J mice exposed to gamma rays.
Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Al-Mazroua HA, Khan MR, Alasmari AF, Alanazi WA, As Sobeai HM, Attia SM. | 01/25/2020 |
| Authors also show that despite their sustained expression of Foxp3, Blimp-1(-/-) RORgammat(+)IL-17-producing Treg lose suppressor function and can promote intestinal inflammation, indicating that repression of Th17-associated cytokines by Blimp-1 is a crucial requirement for RORgammat(+) Treg function. | Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3(+)RORγt(+) Regulatory T Cells.
Ogawa C, Bankoti R, Nguyen T, Hassanzadeh-Kiabi N, Nadeau S, Porritt RA, Couse M, Fan X, Dhall D, Eberl G, Ohnmacht C, Martins GA., Free PMC Article | 01/11/2020 |
| this study shows that RORgammat represses IL-10 production in Th17 cells to maintain their pathogenicity in Inducing intestinal inflammation | RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation.
Sun M, He C, Chen L, Yang W, Wu W, Chen F, Cao AT, Yao S, Dann SM, Dhar TGM, Salter-Cid L, Zhao Q, Liu Z, Cong Y., Free PMC Article | 11/9/2019 |
| These data suggest that SRC3 works with SRC1 to regulate RORgammat-dependent Th17 differentiation but is not essential for RORgammat-dependent thymocyte development. | SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development.
He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z., Free PMC Article | 10/26/2019 |
| Data indicate a role for ROR-gamma (RORgammat) and Bcl-XL protein (Bcl-xL) in limiting interleukin 2 receptor gamma chain (gammac) abundance at the cell surface. | RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x(L) in developing thymocytes.
Ligons DL, Hwang S, Waickman AT, Park JY, Luckey MA, Park JH., Free PMC Article | 10/12/2019 |
| AhR interacts with ROR-gammat and transports ROR-gammat into the cell nucleus. | GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
Chuang HC, Tsai CY, Hsueh CH, Tan TH., Free PMC Article | 10/5/2019 |
| In vitro treatment with a RORgamma agonist generates potent antitumor Type 17 effector cells. | In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.
Hu X, Majchrzak K, Liu X, Wyatt MM, Spooner CJ, Moisan J, Zou W, Carter LL, Paulos CM., Free PMC Article | 08/31/2019 |
| RORgammat in T cells is required for optimal TH2 cell differentiation | Concomitant suppression of T(H)2 and T(H)17 cell responses in allergic asthma by targeting retinoic acid receptor-related orphan receptor γt.
Na H, Lim H, Choi G, Kim BK, Kim SH, Chang YS, Nurieva R, Dong C, Chang SH, Chung Y., Free PMC Article | 08/3/2019 |
| These data demonstrate that RORgammat expressed by tumor-infiltrating Tregs sustains tumor growth by leaving IL6 expression in dendritic cells unchecked. | RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.
Rizzo A, Di Giovangiulio M, Stolfi C, Franzè E, Fehling HJ, Carsetti R, Giorda E, Colantoni A, Ortenzi A, Rugge M, Mescoli C, Monteleone G, Fantini MC. | 07/13/2019 |