| Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis. | Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis.
Guo K, Zhou J. | 10/25/2024 |
| Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene. | Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.
Chen X, Zhang Y, Chen S, Yang Y, Sun G, Pan P., Free PMC Article | 06/25/2024 |
| AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. | AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
Liao R, Chen X, Cao Q, Bai L, Ma C, Dai Z, Dong C., Free PMC Article | 05/14/2024 |
| Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia. | Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Xiong H, Ye J, Luo Q, Li W, Xu N, Yang H. | 11/8/2023 |
| Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer. | Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
Zeng J, Ye Z, Shi S, Liang Y, Meng Q, Zhang Q, Le AD., Free PMC Article | 11/2/2023 |
| High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target. | High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
Greco S, Zannotti A, Pellegrino P, Giantomassi F, Delli Carpini G, D'Agostino M, Goteri G, Ciavattini A, Donati C, Bernacchioni C, Petraglia F, La Teana A, Ciarmela P. | 07/4/2023 |
| Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration. | Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
Lee GK, Kim HY, Park JH. | 06/30/2023 |
| Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis. | Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Padgett LR, Shinkle MR, Rosario S, Stewart TM, Foley JR, Casero RA Jr, Park MH, Chung WK, Mastracci TL., Free PMC Article | 06/23/2023 |
| Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability. | Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
Wu YY, Wu GQ, Cai NL, Xu YM, Lau ATY., Free PMC Article | 04/15/2023 |
| Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. | Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Coni S, Bordone R, Ivy DM, Yurtsever ZN, Di Magno L, D'Amico R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G. | 04/4/2023 |
| Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Wątor E, Wilk P, Biela A, Rawski M, Zak KM, Steinchen W, Bange G, Glatt S, Grudnik P., Free PMC Article | 04/4/2023 |
| Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress. | Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress.
Melis N, Rubera I, Giraud S, Cougnon M, Duranton C, Poet M, Jarretou G, Thuillier R, Counillon L, Hauet T, Pellerin L, Tauc M, Pisani DF., Free PMC Article | 03/5/2023 |
| LncRNA FOXP4-AS promotes the progression of non-small cell lung cancer by regulating the miR-3184-5p/EIF5A axis. | LncRNA FOXP4-AS promotes the progression of non-small cell lung cancer by regulating the miR-3184-5p/EIF5A axis.
Li D, Li Z, YanFei W, Wang Y, Shi J, Liu C, Qu L, Deng S, Xiong D., Free PMC Article | 07/23/2022 |
| Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment. | Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
Park MH, Kar RK, Banka S, Ziegler A, Chung WK., Free PMC Article | 05/28/2022 |
| eIF5A-Independent Role of DHPS in p21(CIP1) and Cell Fate Regulation. | eIF5A-Independent Role of DHPS in p21(CIP1) and Cell Fate Regulation.
Becker AE, Wu PK, Park JI., Free PMC Article | 02/5/2022 |
| Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model. | Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.
Smeltzer S, Quadri Z, Miller A, Zamudio F, Hunter J, Stewart NJF, Saji S, Lee DC, Chaput D, Selenica MB. | 04/17/2021 |
| Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes. | Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes.
Martella M, Catalanotto C, Talora C, La Teana A, Londei P, Benelli D., Free PMC Article | 04/17/2021 |
| Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation. | Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.
Coni S, Serrao SM, Yurtsever ZN, Di Magno L, Bordone R, Bertani C, Licursi V, Ianniello Z, Infante P, Moretti M, Petroni M, Guerrieri F, Fatica A, Macone A, De Smaele E, Di Marcotullio L, Giannini G, Maroder M, Agostinelli E, Canettieri G., Free PMC Article | 04/13/2021 |
| Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. | Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AGL, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S., Free PMC Article | 02/20/2021 |
| A translational program that suppresses metabolism to shield the genome. | A translational program that suppresses metabolism to shield the genome.
Balukoff NC, Ho JJD, Theodoridis PR, Wang M, Bokros M, Llanio LM, Krieger JR, Schatz JH, Lee S., Free PMC Article | 12/12/2020 |
| Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. | Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection.
Manjunath H, Zhang H, Rehfeld F, Han J, Chang TC, Mendell JT., Free PMC Article | 10/3/2020 |
| Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission. | Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK., Free PMC Article | 09/19/2020 |
| The results revealed that EIF5A regulated the proliferation of pancreatic cancer through the SHH signaling pathway while decreasing the gemcitabine sensitivity. | EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway.
Wang Z, Jiang J, Qin T, Xiao Y, Han L., Free PMC Article | 07/18/2020 |
| DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFbeta/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53 | DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFβ/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53.
Güth R, Adamian Y, Geller C, Molnar J, Maddela J, Kutscher L, Bhakta K, Meade K, Kim SL, Agajanian M, Kelber JA., Free PMC Article | 06/27/2020 |
| EIF5A1 may be a regulator of trophoblast function at the maternal-fetal interface and low levels of EIF5A1 and ARAF may be associated with recurrent miscarriage. | EIF5A1 promotes trophoblast migration and invasion via ARAF-mediated activation of the integrin/ERK signaling pathway.
Zhang J, Mo HQ, Tian FJ, Zeng WH, Liu XR, Ma XL, Li X, Qin S, Fan CF, Lin Y., Free PMC Article | 11/16/2019 |