| RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4(+) T-cell-dependent antitumor immunity. | RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4(+) T-cell-dependent antitumor immunity.
Zhang Z, Luo L, Xing C, Chen Y, Xu P, Li M, Zeng L, Li C, Ghosh S, Della Manna D, Townes T, Britt WJ, Wajapeyee N, Sleckman BP, Chong Z, Leavenworth JW, Yang ES., Free PMC Article | 04/30/2022 |
| Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4. | Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, Wang R, Mao Z, Zhang Y, Li Q, Zuo G, Miao D, Jin J., Free PMC Article | 04/23/2022 |
| Functional associations among DNA, transcription, and chromatin over PcG-repressed genes can be regulated by the formation of R-loops and that RING1B may play a vital role in this pathway for transcriptional repression. | R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes.
Skourti-Stathaki K, Torlai Triglia E, Warburton M, Voigt P, Bird A, Pombo A., Free PMC Article | 06/29/2019 |
| Ring1A/B regulate and maintain AML stem cells in part by repressing Glis2 expression, which promotes their differentiation. | Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Shima H, Takamatsu-Ichihara E, Shino M, Yamagata K, Katsumoto T, Aikawa Y, Fujita S, Koseki H, Kitabayashi I. | 05/18/2019 |
| Data show that RNF2 promotes STAT1/STAT2 disassociation from DNA. | Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA.
Liu S, Jiang M, Wang W, Liu W, Song X, Ma Z, Zhang S, Liu L, Liu Y, Cao X. | 12/30/2017 |
| the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1 | The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.
Illingworth RS, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM, Adams IR, Bickmore WA., Free PMC Article | 12/19/2015 |
| RNF2 associates with AMBRA1 to act as an E3 ligase to ubiquitinate AMBRA1 via K48 linkage. | RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy.
Xia P, Wang S, Huang G, Du Y, Zhu P, Li M, Fan Z., Free PMC Article | 04/4/2015 |
| The polycomb component Ring1B regulates the timed termination of Fezf2 expression and thus subcerebral projection neuron production during mouse neocortical development. | The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development.
Morimoto-Suzki N, Hirabayashi Y, Tyssowski K, Shinga J, Vidal M, Koseki H, Gotoh Y. | 01/10/2015 |
| Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells. | Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice.
Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H. | 09/13/2014 |
| Af9 mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC promoter to constrain basal alpha-ENaC transcription in collecting duct cells. | Physical and functional interaction of Rnf2 with Af9 regulates basal and aldosterone-stimulated transcription of the α-ENaC gene in a renal collecting duct cell line.
Yu ZY, Kong Q, Kone BC., Free PMC Article | 09/6/2014 |
| Ring1b mediates Meis2 promoter and midbrain-specific enhancer association. | Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.
Kondo T, Isono K, Kondo K, Endo TA, Itohara S, Vidal M, Koseki H. | 03/22/2014 |
| Aurora B and Ring1B co-occupy active promoters in resting lymphocytes. | The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes.
Frangini A, Sjöberg M, Roman-Trufero M, Dharmalingam G, Haberle V, Bartke T, Lenhard B, Malumbres M, Vidal M, Dillon N. | 01/11/2014 |
| Fbxl10 has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells. | Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Wu X, Johansen JV, Helin K. | 05/25/2013 |
| identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 and Rnf2, two central components of the Polycomb repressive complex 1 (PRC1) | PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Yokobayashi S, Liang CY, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AH. | 04/20/2013 |
| Ring1b inactivation in differentiated islet beta cells (Ring1b(betaKO)) did not cause derepression, even after multiple rounds of cell division, suggesting a role for Ring1b in the establishment but not the maintenance of repression | Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells.
van Arensbergen J, García-Hurtado J, Maestro MA, Correa-Tapia M, Rutter GA, Vidal M, Ferrer J., Free PMC Article | 03/2/2013 |
| loss of Ring1a/b postnatally results in defective cervical loops and disturbances of enamel and dentin formation in continuously growing incisors | Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors.
Lapthanasupkul P, Feng J, Mantesso A, Takada-Horisawa Y, Vidal M, Koseki H, Wang L, An Z, Miletich I, Sharpe PT. | 08/25/2012 |
| It was shown that Ring1B interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed, Ring1B and CpG islands in chromatin, H2A.Z still blanketed polycomb target loci in the absence of Suz12, Eed, or Ring1B. | PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.
Illingworth RS, Botting CH, Grimes GR, Bickmore WA, Eskeland R., Free PMC Article | 08/25/2012 |
| Data provide a valuable basis for future investigations aimed at eukaryotic DING proteins, revealing that these proteins seem ubiquitous in mouse tissue. | Eukaryotic DING proteins are endogenous: an immunohistological study in mouse tissues.
Collombet JM, Elias M, Gotthard G, Four E, Renault F, Joffre A, Baubichon D, Rochu D, Chabrière E., Free PMC Article | 10/4/2010 |
| Ring1B and Suv39h1 have mutually exclusive roles in regulating distinct chromatin states at key developmental genes, and play a part in how lineage specification can be reinforced during early development | Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.
Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O'Neill L, Azuara V., Free PMC Article | 08/30/2010 |
| Ring1B-mediated chromatin compaction acts to directly limit transcription in embryonic stem cells. | Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.
Eskeland R, Leeb M, Grimes GR, Kress C, Boyle S, Sproul D, Gilbert N, Fan Y, Skoultchi AI, Wutz A, Bickmore WA., Free PMC Article | 06/14/2010 |
| polycomb protein Ring1B regulation by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome | Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.
Zaaroor-Regev D, de Bie P, Scheffner M, Noy T, Shemer R, Heled M, Stein I, Pikarsky E, Ciechanover A., Free PMC Article | 05/31/2010 |
| Data suggest a role for Ring1B in maintenance of the undifferentiated state of embryonic neural stem/progenitor cells. They also suggest that Ring1B may modulate the differentiation potential of NSCs to neurons and glia. | Maintenance of undifferentiated state and self-renewal of embryonic neural stem cells by Polycomb protein Ring1B.
Román-Trufero M, Méndez-Gómez HR, Pérez C, Hijikata A, Fujimura Y, Endo T, Koseki H, Vicario-Abejón C, Vidal M. | 01/21/2010 |
| Studies in mammalian cells have found a multiplicity of protein complexes containing Ring1A and Ring1B, suggesting an expanded regulatory role for Ring1A, Ring1B proteins in the epigenetic regulation of gene expression. | Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.
Vidal M. | 01/21/2010 |
| The Polycomb group proteins Ezh2 and Rnf2 are independently required for genomic contraction and imprinted silencing. | Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.
Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH. | 01/21/2010 |
| Ring1b is essential to stably maintain an undifferentiated state of mouse ES cells by repressing genes with important roles during differentiation and development | Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.
van der Stoop P, Boutsma EA, Hulsman D, Noback S, Heimerikx M, Kerkhoven RM, Voncken JW, Wessels LF, van Lohuizen M., Free PMC Article | 01/21/2010 |