| MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression. | MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression.
Shen Y, Zhang Y, Wang Q, Jiang B, Jiang X, Luo B., Free PMC Article | 02/16/2024 |
| Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor. | Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.
Meril S, Bahlsen M, Eisenstein M, Savidor A, Levin Y, Bialik S, Pietrokovski S, Kimchi A., Free PMC Article | 01/3/2024 |
| miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2. | miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
Jia Z, Wang Y, Gao J, Zheng M, Wang P, Zu G., Free PMC Article | 11/1/2023 |
| Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation. | Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.
Alard A, Katsara O, Rios-Fuller T, Parra C, Ozerdem U, Ernlund A, Schneider RJ., Free PMC Article | 10/13/2023 |
| Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity. | Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.
She R, Luo J, Weissman JS., Free PMC Article | 07/24/2023 |
| Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation. | Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.
Liu Y, Cui J, Hoffman AR, Hu JF., Free PMC Article | 03/9/2023 |
| DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells. | DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells.
David M, Olender T, Mizrahi O, Weingarten-Gabbay S, Friedlander G, Meril S, Goldberg N, Savidor A, Levin Y, Salomon V, Stern-Ginossar N, Bialik S, Kimchi A., Free PMC Article | 10/1/2022 |
| Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis. | Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4γ2 axis.
Tong J, Lu J, Mao X, Zhu Z, Wang Y, Lou M, Zhang K., Free PMC Article | 04/16/2022 |
| Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant. | Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant.
Zhang J, Zhang R, Ye Y., Free PMC Article | 02/26/2022 |
| A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells. | A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.
Volta V, Pérez-Baos S, de la Parra C, Katsara O, Ernlund A, Dornbaum S, Schneider RJ., Free PMC Article | 01/8/2022 |
| MiR-144-3p-mediated dysregulation of EIF4G2 contributes to the development of hepatocellular carcinoma through the ERK pathway. | MiR-144-3p-mediated dysregulation of EIF4G2 contributes to the development of hepatocellular carcinoma through the ERK pathway.
Li S, Shao J, Lou G, Wu C, Liu Y, Zheng M., Free PMC Article | 09/11/2021 |
| MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2. | MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2.
Gao S, Liu L, Zhu S, Wang D, Wu Q, Ning G, Feng S., Free PMC Article | 04/3/2021 |
| LncRNA SDHAP1 confers paclitaxel resistance of ovarian cancer by regulating EIF4G2 expression via miR-4465. | LncRNA SDHAP1 confers paclitaxel resistance of ovarian cancer by regulating EIF4G2 expression via miR-4465.
Zhao H, Wang A, Zhang Z. | 02/13/2021 |
| 5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs. | 5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs.
Haizel SA, Bhardwaj U, Gonzalez RL Jr, Mitra S, Goss DJ., Free PMC Article | 01/23/2021 |
| Host DAP5, but not the full-length eIF4GI, is required for Coxsackievirus B3 translation of input viral RNA. | The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA.
Dave P, George B, Raheja H, Rani P, Behera P, Das S., Free PMC Article | 06/27/2020 |
| Findings suggest a new translational regulatory mechanism for DSCR1.4 expressions and a novel function of DAP5 as a positive regulator of DSCR1.4 mRNA translation induced in soma and axon of hippocampal neurons. | DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.
Seo JY, Jung Y, Kim DY, Ryu HG, Lee J, Kim SW, Kim KT., Free PMC Article | 04/4/2020 |
| the present results suggested that circEIF4G2 may be a novel oncogene in CC. Furthermore, circEIF4G2 may promote CC cell growth and migration by sponging miR-218, thus increasing the expression levels of HOXA1. | circEIF4G2 modulates the malignant features of cervical cancer via the miR‑218/HOXA1 pathway.
Mao Y, Zhang L, Li Y., Free PMC Article | 08/3/2019 |
| DAP5 knockdown from human ESCs (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation | Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cells.
Yoffe Y, David M, Kalaora R, Povodovski L, Friedlander G, Feldmesser E, Ainbinder E, Saada A, Bialik S, Kimchi A., Free PMC Article | 06/24/2017 |
| Data show that microRNA miR-379 potentiated lung cancer (LCa) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR. | Suppression of EIF4G2 by miR-379 potentiates the cisplatin chemosensitivity in nonsmall cell lung cancer cells.
Hao GJ, Hao HJ, Ding YH, Wen H, Li XF, Wang QR, Zhang BB. | 06/3/2017 |
| These results indicate that miR-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R. | miR-139 is up-regulated in osteoarthritis and inhibits chondrocyte proliferation and migration possibly via suppressing EIF4G2 and IGF1R.
Hu W, Zhang W, Li F, Guo F, Chen A. | 05/13/2017 |
| The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death. | Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes.
Hanson PJ, Ye X, Qiu Y, Zhang HM, Hemida MG, Wang F, Lim T, Gu A, Cho B, Kim H, Fung G, Granville DJ, Yang D., Free PMC Article | 12/31/2016 |
| Knockdown of EIF4G2 recapitulated the effects of mir-139, whereas restoring EIF4G2 expression rescued the mir-139 phenotype. elevated miR-139-5p expression is associated with a favorable outcome in acute myeloid leukemia. | miR-139-5p controls translation in myeloid leukemia through EIF4G2.
Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink MM, Klusmann JH. | 08/27/2016 |
| findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation | DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.
Liberman N, Gandin V, Svitkin YV, David M, Virgili G, Jaramillo M, Holcik M, Nagar B, Kimchi A, Sonenberg N., Free PMC Article | 07/25/2015 |
| Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity. | Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.
Mazan-Mamczarz K, Zhao XF, Dai B, Steinhardt JJ, Peroutka RJ, Berk KL, Landon AL, Sadowska M, Zhang Y, Lehrmann E, Becker KG, Shaknovich R, Liu Z, Gartenhaus RB., Free PMC Article | 06/21/2014 |
| DAP5, a translation initiation factor shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 mRNA. | The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA.
Weingarten-Gabbay S, Khan D, Liberman N, Yoffe Y, Bialik S, Das S, Oren M, Kimchi A. | 04/5/2014 |