| mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. | mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.
Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjörnsson M, Marciano R, Scharov K, Planque M, Vriens K, Christen S, Funk CM, Hassiepen C, Kahler A, Heider B, Picard D, Lim JKM, Stefanski A, Bendrin K, Vargas-Toscano A, Kahlert UD, Stühler K, Remke M, Elkabets M, Grünewald TGP, Reichert AS, Fendt SM, Schulze A, Reifenberger G, Rotblat B, Leprivier G., Free PMC Article | 07/15/2024 |
| Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation. | Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
Al-Lamki RS, Tolkovsky AM, Alawwami M, Lu W, Field SF, Wang J, Pober JS, Bradley JR. | 07/1/2024 |
| miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels. | miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels.
Nagaraj S, Stankiewicz-Drogon A, Darzynkiewicz E, Wojda U, Grzela R., Free PMC Article | 02/23/2024 |
| Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration. | Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
Lee GK, Kim HY, Park JH. | 06/30/2023 |
| 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. | 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis.
He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH, Wang S, Song M, Qu J., Free PMC Article | 04/14/2023 |
| 4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer. | 4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.
Wang Y, Lei J, Zhang S, Wang X, Jin J, Liu Y, Gan M, Yuan Y, Sun L, Li X, Han T, Wang JB., Free PMC Article | 12/31/2022 |
| Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection. | Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection.
Tang Y, Luo J, Yang Y, Liu S, Zheng H, Zhan Y, Fan S, Wen Q., Free PMC Article | 07/2/2022 |
| Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m(6)A demethylation of EIF4EBP1 and MLST8 mRNA. | Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m(6)A demethylation of EIF4EBP1 and MLST8 mRNA.
Zhang L, Su X., Free PMC Article | 06/25/2022 |
| circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis. | circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.
Gui CP, Liao B, Luo CG, Chen YH, Tan L, Tang YM, Li JY, Hou Y, Song HD, Lin HS, Xu QH, Yao GS, Yao HH, Xi-Liu, Luo JH, Cao JZ, Wei JH., Free PMC Article | 03/26/2022 |
| Targeting of EIF4EBP1 by miR-99a-3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression. | Targeting of EIF4EBP1 by miR-99a-3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression.
Yang M, Yang B, Deng D., Free PMC Article | 03/19/2022 |
| CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis. | CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis.
Koncha RR, Ramachandran G, Sepuri NBV, Ramaiah KVA. | 10/16/2021 |
| Upregulation of MTOR, RPS6KB1, and EIF4EBP1 in the whole blood samples of Iranian patients with multiple sclerosis compared to healthy controls. | Upregulation of MTOR, RPS6KB1, and EIF4EBP1 in the whole blood samples of Iranian patients with multiple sclerosis compared to healthy controls.
Akbarian F, Tabatabaiefar MA, Shaygannejad V, Shahpouri MM, Badihian N, Sajjadi R, Dabiri A, Jalilian N, Noori-Daloii MR. | 09/4/2021 |
| The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors. | The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors.
Goss KL, Koppenhafer SL, Waters T, Terry WW, Wen KK, Wu M, Ostergaard J, Gordon PM, Gordon DJ., Free PMC Article | 07/31/2021 |
| BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma. | BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma.
Wan P, Chen Z, Zhong W, Jiang H, Huang Z, Peng D, He Q, Chen N., Free PMC Article | 07/31/2021 |
| The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. | The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.
Böhm R, Imseng S, Jakob RP, Hall MN, Maier T, Hiller S. | 06/26/2021 |
| BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models. | BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Githaka JM, Tripathi N, Kirschenman R, Patel N, Pandya V, Kramer DA, Montpetit R, Zhu LF, Sonenberg N, Fahlman RP, Danial NN, Underhill DA, Goping IS., Free PMC Article | 06/5/2021 |
| 4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs. | 4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs.
Alasad K, Voeltzke K, Levin L, Reifenberger G, Leprivier G, Rotblat B., Free PMC Article | 05/1/2021 |
| Cyclin-dependent kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis-G1 transition. | Cyclin-dependent kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis-G1 transition.
Mitchell DC, Menon A, Garner AL., Free PMC Article | 04/24/2021 |
| Eukaryotic Initiation Factor 4E phosphorylation acts a switch for its binding to 4E-BP1 and mRNA cap assembly. | Eukaryotic Initiation Factor 4E phosphorylation acts a switch for its binding to 4E-BP1 and mRNA cap assembly.
Batool A, Majeed ST, Aashaq S, Majeed R, Andrabi KI. | 01/9/2021 |
| Authors uncovered the role of cyclin-dependent kinase 4 (CDK4), a clinically validated kinase important for cell-cycle progression, in regulating cap-dependent translation via phosphorylation of the tumor suppressor 4E-BP1. | Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1.
Mitchell DC, Menon A, Garner AL., Free PMC Article | 07/25/2020 |
| The p-4E-BP1 expression, especially in Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) (cHCC-CC) cases with a cholangiocarcinoma (CC) component, was a notable Akt/mTOR pathway-related factor associated with poor prognosis. | Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma: significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis.
Okumura Y, Kohashi K, Tanaka Y, Kato M, Maehara Y, Ogawa Y, Oda Y. | 06/27/2020 |
| Study showed higher expression of 4EB-P1 in prostate cancer (PCa) compared to benign tissues with local gradients in relation to the border of the tumor. These results suggest an important role of intratumor heterogeneity for the use of 4EBP1 as biomarkers in PCa. | Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer.
Russo GI, Hennenlotter J, Vogel U, Kühs U, Wurm TM, Gerber V, Neumann T, Cimino S, Stenzl A, Todenhöfer T., Free PMC Article | 05/9/2020 |
| The most highly phosphorylated mitotic 4E-BP1 isoform (delta) did not interact with eIF4E, whereas a distinct 4E-BP1 phospho-isoform, EB-gamma, phosphorylated at Thr-70, Ser-83, and Ser-101, bound to eIF4E during mitosis. | Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E).
Sun R, Cheng E, Velásquez C, Chang Y, Moore PS., Free PMC Article | 03/21/2020 |
| Scutellarin (SCU) can suppress proliferation and promote apoptosis in A549 cells through AKT/mTOR/4EBP1 and STAT3 pathways. This suggests that SCU may be developed into a promising antitumor agent for treating non-small cell lung cancer (NSCLC) | Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways.
Cao P, Liu B, Du F, Li D, Wang Y, Yan X, Li X, Li Y., Free PMC Article | 03/7/2020 |
| findings suggest that EIF4E-BP1 acts as a tumor suppressor in HNSCC and that 4E-BP1 dephosphorylation mediates the therapeutic response to mTORi, providing a mechanistic biomarker for future precision oncology trials | 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.
Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS., Free PMC Article | 01/4/2020 |