| Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/beta-catenin signaling pathway. | Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Feiteng C, Lei C, Deng L, Chaoliang X, Zijie X, Yi S, Minglei S., Free PMC Article | 04/9/2022 |
| Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis. | Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
Hu M, Wang Y, Liu Z, Yu Z, Guan K, Liu M, Wang M, Tan J, Huang L. | 08/7/2021 |
| In summary, relaxin deficiency results in increased cervical collagen in late pregnancy, which is not explained by a reduction in Mmp expression or activity or decreased Rxfp1. | Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity.
Marshall SA, McGuane JT, Soh YM, Gehring HM, Simpson E, Parry LJ. | 09/7/2019 |
| the data demonstrate that pregnant Rln(-/-) mice do not have the typical characteristics of preeclampsia. However, these mice show evidence of proteinuria, but we suggest that this results from systemic renal vascular dysfunction before pregnancy. | Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice.
O'Sullivan KP, Marshall SA, Cullen S, Saunders T, Hannan NJ, Senadheera SN, Parry LJ. | 07/21/2018 |
| Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. | Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Howatt DA, Dajee M, Xie X, Moorleghen J, Rateri DL, Balakrishnan A, Da Cunha V, Johns DG, Gutstein DE, Daugherty A, Lu H., Free PMC Article | 03/3/2018 |
| SLX has roles in vascular oxidative stress, endothelial dysfunction and atherosclerotic plaque burden | Anti-atherosclerotic effects of serelaxin in apolipoprotein E-deficient mice.
Tiyerili V, Beiert T, Schatten H, Camara B, Jehle J, Schrickel JW, Nickenig G, Andrié RP. | 12/30/2017 |
| The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review) | Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report.
Garella R, Squecco R, Baccari MC. | 11/4/2017 |
| This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient mice. | Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice.
Marshall SA, Leo CH, Senadheera SN, Girling JE, Tare M, Parry LJ. | 07/1/2017 |
| Passive mechanical wall properties differed at younger ages, suggesting that Relaxin expression has only minor effects on vascular aging. | Differential effects of relaxin deficiency on vascular aging in arteries of male mice.
Jelinic M, Tare M, Conrad KP, Parry LJ., Free PMC Article | 04/2/2016 |
| we demonstrate endothelial dysfunction and impaired arterial wall remodeling in male mice deficient in relaxin. Thus, our results highlight a role for endogenous relaxin in the maintenance of normal mesenteric artery structure and function in males. | A vasoactive role for endogenous relaxin in mesenteric arteries of male mice.
Leo CH, Jelinic M, Gooi JH, Tare M, Parry LJ., Free PMC Article | 06/20/2015 |
| data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2 | RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro.
Duarte C, Kobayashi Y, Kawamoto T, Moriyama K. | 02/14/2015 |
| Relaxin and estrogen enhance matrix loss in the temporomandibular joint disc. | Mechanisms for relaxin's modulation of MMPs and matrix loss in fibrocartilages.
Kapila S, Park Y, Ahmad N, Hosomichi J, Hayami T, Tacon C. | 05/3/2014 |
| Relaxin deficiency compromises uterine artery remodeling in older pregnant females. | Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment.
Gooi JH, Richardson ML, Jelinic M, Girling JE, Wlodek ME, Tare M, Parry LJ. | 03/8/2014 |
| RLX improves impaired wound healing, enhances staining of MMP-11 (matrix metalloproteinase-11) and increases wound-breaking strength at day 12 in diabetic mice. | Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice.
Bitto A, Irrera N, Minutoli L, Calò M, Lo Cascio P, Caccia P, Pizzino G, Pallio G, Micali A, Vaccaro M, Saitta A, Squadrito F, Altavilla D., Free PMC Article | 10/19/2013 |
| Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice | Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice.
Soh YM, Tiwari A, Mahendroo M, Conrad KP, Parry LJ., Free PMC Article | 02/2/2013 |
| Data suggest that in proximal colon, relaxin affects constitutive nNOS (neuronal nitric oxide synthase) and eNOS (endothelial cell NOS) but not iNOS (inducible NOS), increasing enzyme activity and reducing muscle tone. | Relaxin exerts two opposite effects on mechanical activity and nitric oxide synthase expression in the mouse colon.
Baccari MC, Traini C, Garella R, Cipriani G, Vannucchi MG. | 01/12/2013 |
| The secretion of relaxin by the engineered myoblasts accelerated and enhanced the cardiomyogenic potential of the co-culture. | Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures.
Formigli L, Francini F, Nistri S, Margheri M, Luciani G, Naro F, Silvertown JD, Orlandini SZ, Meacci E, Bani D. | 01/21/2010 |
| Endogenous relaxin expression is decreased in murine allergic airways disease, whereas exogenous relaxin represents a novel treatment capable of reversing established airway remodeling and airway hyperresponsiveness. | Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease.
Royce SG, Miao YR, Lee M, Samuel CS, Tregear GW, Tang ML. | 01/21/2010 |
| long-term exposure to relaxin confers growth inhibitory and anti-invasive properties in oestrogen-independent tumours in vivo, which may in part be mediated through a down-regulation of S100A4 | Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells.
Radestock Y, Hoang-Vu C, Hombach-Klonisch S., Free PMC Article | 01/21/2010 |
| LGR7-expressing cells in the stroma are both necessary and sufficient for relaxin to promote proliferation and inhibit apoptosis in both stromal and epithelial cells of cervix and vagina. | Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina.
Yao L, Agoulnik AI, Cooke PS, Meling DD, Sherwood OD., Free PMC Article | 01/21/2010 |
| although up-regulated in its expression, endogenous relaxin had no significant effect on the progression of cardiac maladaptation and dysfunction in the setting of chronic pressure overload | Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis.
Xu Q, Lekgabe ED, Gao XM, Ming Z, Tregear GW, Dart AM, Bathgate RA, Samuel CS, Du XJ. | 01/21/2010 |
| RLX can reverse the altered ileal motility of mdx mice to a normal pattern, likely by upregulating NOS II expression and NO biosynthesis in the ileal smooth muscle | Reversal by relaxin of altered ileal spontaneous contractions in dystrophic (mdx) mice through a nitric oxide-mediated mechanism.
Baccari MC, Nistri S, Vannucchi MG, Calamai F, Bani D. | 01/21/2010 |
| neither Insl3 nor Lgr8 contribute to the RLN signaling pathway; Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo | Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.
Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE, Agoulnik AI. | 01/21/2010 |
| Endogenous RLX acts as modulating factor in tubulointerstitial fibrosis. This is likely to be via direct effects on renal myofibroblast function. | Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis.
Hewitson TD, Mookerjee I, Masterson R, Zhao C, Tregear GW, Becker GJ, Samuel CS. | 01/21/2010 |
| Binds with high affinity to the human, mouse, and rat RXFP1 (primary relaxin) receptor but with a slightly lower affinity to that of human H2 relaxin; effectively inhibits collagen deposition and accumulation (fibrosis) over long-term treatment periods. | Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin.
Samuel CS, Lin F, Hossain MA, Zhao C, Ferraro T, Bathgate RA, Tregear GW, Wade JD. | 01/21/2010 |