| Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology. | Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology.
Wang Y, Li Q, Zhang J, Liu P, Zheng H, Chen L, Wang Z, Tan C, Zhang M, Zhang H, Miao W, Wang Y, Xuan X, Yi G, Wang P., Free PMC Article | 11/2/2023 |
| Essential role of MESP1-RING1A complex in cardiac differentiation. | Essential role of MESP1-RING1A complex in cardiac differentiation.
Liang Q, Wang S, Zhou X, Li Y, Xing S, Sha Y, Yang F, Huang W, Liu N, Li Z, Chen Y, Xu Y, Zhu P, Lan F, Sun N. | 12/3/2022 |
| The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon. | The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.
Eto H, Kishi Y, Yakushiji-Kaminatsui N, Sugishita H, Utsunomiya S, Koseki H, Gotoh Y., Free PMC Article | 12/5/2020 |
| Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression. | Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression.
Bar C, Cohen I, Zhao D, Pothula V, Litskevitch A, Koseki H, Zheng D, Ezhkova E., Free PMC Article | 08/29/2020 |
| Ring1A/B regulate and maintain AML stem cells in part by repressing Glis2 expression, which promotes their differentiation. | Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Shima H, Takamatsu-Ichihara E, Shino M, Yamagata K, Katsumoto T, Aikawa Y, Fujita S, Koseki H, Kitabayashi I. | 05/18/2019 |
| Data suggest that the RING1-MEIS1/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry. | RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression.
Yakushiji-Kaminatsui N, Kondo T, Endo TA, Koseki Y, Kondo K, Ohara O, Vidal M, Koseki H. | 05/28/2016 |
| identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 and Rnf2, two central components of the Polycomb repressive complex 1 (PRC1) | PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Yokobayashi S, Liang CY, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AH. | 04/20/2013 |
| loss of Ring1a/b postnatally results in defective cervical loops and disturbances of enamel and dentin formation in continuously growing incisors | Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors.
Lapthanasupkul P, Feng J, Mantesso A, Takada-Horisawa Y, Vidal M, Koseki H, Wang L, An Z, Miletich I, Sharpe PT. | 08/25/2012 |
| Studies in mammalian cells have found a multiplicity of protein complexes containing Ring1A and Ring1B, suggesting an expanded regulatory role for Ring1A, Ring1B proteins in the epigenetic regulation of gene expression. | Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.
Vidal M. | 01/21/2010 |
| Ring1A/B-mediated Polycomb silencing functions downstream of the core transcriptional regulatory circuitry to maintain ES cell identity | Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.
Endoh M, Endo TA, Endoh T, Fujimura Y, Ohara O, Toyoda T, Otte AP, Okano M, Brockdorff N, Vidal M, Koseki H. | 01/21/2010 |
| muscle RING finger 1 and muscle RING finger 3 as key E3 ubiquitin ligases for the ubiquitin proteasome system-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies | Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Fielitz J, Kim MS, Shelton JM, Latif S, Spencer JA, Glass DJ, Richardson JA, Bassel-Duby R, Olson EN., Free PMC Article | 01/21/2010 |
| poised RNAP configuration is enforced by Polycomb Repressor Complex-mediated ubiquitination of H2A, conditional deletion of Ring1A and Ring1B leads to loss of ubiquitination of H2A, release of poised RNAP, and subsequent gene de-repression. | Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells.
Stock JK, Giadrossi S, Casanova M, Brookes E, Vidal M, Koseki H, Brockdorff N, Fisher AG, Pombo A. | 01/21/2010 |
| Data show that Bmi-1 and Ring1A positively regulate histone H2A ubiquitylation. | Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
Cao R, Tsukada Y, Zhang Y. | 01/21/2010 |
| Ring/Sce interacts directly with PcG proteins | The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.
Gorfinkiel N, Fanti L, Melgar T, García E, Pimpinelli S, Guerrero I, Vidal M. | 01/21/2010 |
| Study shows anterior homeotic transformations of the axial skeleton of YY1 mutant mice and reduced phenotypes in mice that are deficient in the class II Polycomb group genes Ring1/Ring1A, indicating a genetic interaction between those two genes. | Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.
Lorente M, Pérez C, Sánchez C, Donohoe M, Shi Y, Vidal M. | 01/21/2010 |