| RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression. | RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression.
Yang S, Min X, Hu L, Zheng M, Lu S, Zhao M, Jia S. | 03/28/2024 |
| Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation. | Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation.
Yang S, Du P, Cui H, Zheng M, He W, Gao X, Hu Z, Jia S, Lu Q, Zhao M., Free PMC Article | 11/8/2023 |
| Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis. | Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.
Lemeille S, Paschaki M, Baas D, Morlé L, Duteyrat JL, Ait-Lounis A, Barras E, Soulavie F, Jerber J, Thomas J, Zhang Y, Holtzman MJ, Kistler WS, Reith W, Durand B., Free PMC Article | 10/31/2020 |
| RFX1 transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development. | RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos.
Wang B, Qi T, Chen SQ, Ye L, Huang ZS, Li H. | 01/27/2018 |
| Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging. | Regulatory factor X1 depresses ApoE-dependent Aβ uptake by miRNA-124 in microglial response to oxidative stress.
Feng CZ, Yin JB, Yang JJ, Cao L. | 11/11/2017 |
| This study suggests that ciliogenic Rfx transcription factors regulate Msi1 expression in neural stem/progenitor cells. | Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.
Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H., Free PMC Article | 05/16/2015 |
| regulatory factor 1 directly regulates CD44 expression in glioblastoma | Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma.
Feng C, Zhang Y, Yin J, Li J, Abounader R, Zuo Z., Free PMC Article | 04/25/2015 |
| RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter. | Spermatogenesis associated 4 promotes Sertoli cell proliferation modulated negatively by regulatory factor X1.
Jiang J, Zhang N, Shiba H, Li L, Wang Z., Free PMC Article | 07/26/2014 |
| Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma. | Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development.
Watts JA, Zhang C, Klein-Szanto AJ, Kormish JD, Fu J, Zhang MQ, Zaret KS., Free PMC Article | 01/28/2012 |
| These results suggest a significant expression of RFX1 proteins in the mammalian brain. | Expression of the transcription factor regulatory factor X1 in the mouse brain.
Feng C, Li J, Zuo Z., Free PMC Article | 10/29/2011 |
| RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter. | Regulation of FGF1 gene promoter through transcription factor RFX1.
Hsu YC, Liao WC, Kao CY, Chiu IM., Free PMC Article | 05/31/2010 |
| RFX1 may play roles in haploid cells during mouse spermatogenesis | Differential expression of Rfx1-4 during mouse spermatogenesis.
Kistler WS, Horvath GC, Dasgupta A, Kistler MK., Free PMC Article | 02/15/2010 |
| RFX1 regulates expression of genes that are essential for early embryonic development/survival and that RFX1 function can not be compensated by other RFX1 family members. | Knockout of the regulatory factor X1 gene leads to early embryonic lethality.
Feng C, Xu W, Zuo Z., Free PMC Article | 01/21/2010 |
| RFX1 mediates the immediate early response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells. | RFX1 mediates the serum-induced immediate early response of Id2 gene expression.
Wang KR, Nemoto T, Yokota Y. | 01/21/2010 |