| TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons. | TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.
Zubia MV, Yong AJH, Holtz KM, Huang EJ, Jan YN, Jan LY., Free PMC Article | 07/2/2024 |
| Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis. | Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis.
Liang P, Zhang Y, Wan YCS, Ma S, Dong P, Lowry AJ, Francis SJ, Khandelwal S, Delahunty M, Telen MJ, Strouse JJ, Arepally GM, Yang H., | 02/5/2024 |
| ANO6 is a reliable prognostic biomarker and correlates to macrophage polarization in breast cancer. | ANO6 is a reliable prognostic biomarker and correlates to macrophage polarization in breast cancer.
Tang LH, Dai M, Wang DH., Free PMC Article | 11/18/2023 |
| Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. | Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.
Zhang Y, Liang P, Yang L, Shan KZ, Feng L, Chen Y, Liedtke W, Coyne CB, Yang H., Free PMC Article | 07/2/2022 |
| Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia. | Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.
Hernandez-Clavijo A, Gonzalez-Velandia KY, Rangaswamy U, Guarneri G, Boscolo-Rizzo P, Tofanelli M, Gardenal N, Sanges R, Dibattista M, Tirelli G, Menini A. | 06/18/2022 |
| TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation. | TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.
Connolly A, Panes R, Tual M, Lafortune R, Bellemare-Pelletier A, Gagnon E. | 12/18/2021 |
| Molecular underpinning of intracellular pH regulation on TMEM16F. | Molecular underpinning of intracellular pH regulation on TMEM16F.
Liang P, Yang H., Free PMC Article | 10/23/2021 |
| TMEM16F and dynamins control expansive plasma membrane reservoirs. | TMEM16F and dynamins control expansive plasma membrane reservoirs.
Deisl C, Hilgemann DW, Syeda R, Fine M., Free PMC Article | 09/4/2021 |
| Ca(2+) Sensitivity of Anoctamin 6/TMEM16F Is Regulated by the Putative Ca(2+)-Binding Reservoir at the N-Terminal Domain. | Ca(2+) Sensitivity of Anoctamin 6/TMEM16F Is Regulated by the Putative Ca(2+)-Binding Reservoir at the N-Terminal Domain.
Roh JW, Hwang GE, Kim WK, Nam JH., Free PMC Article | 08/28/2021 |
| Hyperuricemia enhances procoagulant activity of vascular endothelial cells through TMEM16F regulated phosphatidylserine exposure and microparticle release. | Hyperuricemia enhances procoagulant activity of vascular endothelial cells through TMEM16F regulated phosphatidylserine exposure and microparticle release.
Yu H, Wang Z, Li Z, An Y, Yan M, Ji S, Xu M, Wang L, Dong W, Shi J, Gao C. | 08/28/2021 |
| Lysophosphatidic acid-induced pro-thrombotic phosphatidylserine exposure and ionophore-induced microvesiculation is mediated by the scramblase TMEM16F in erythrocytes. | Lysophosphatidic acid-induced pro-thrombotic phosphatidylserine exposure and ionophore-induced microvesiculation is mediated by the scramblase TMEM16F in erythrocytes.
Öhlinger T, Müllner EW, Fritz M, Sauer T, Werning M, Baron DM, Salzer U. | 01/16/2021 |
| Temperature-dependent increase in the calcium sensitivity and acceleration of activation of ANO6 chloride channel variants. | Temperature-dependent increase in the calcium sensitivity and acceleration of activation of ANO6 chloride channel variants.
Lin H, Jun I, Woo JH, Lee MG, Kim SJ, Nam JH., Free PMC Article | 12/5/2020 |
| TMEM16A and TMEM16F support membrane exocytosis and are essential for plasma membrane insertion of CFTR. | Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.
Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lérias JR, Wanitchakool P, Schreiber R, Kunzelmann K. | 06/27/2020 |
| GD-N induced cell death in HEK293 and HAP1 cells was depending on expression of endogenous TMEM16F. | Contribution of TMEM16F to pyroptotic cell death.
Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K., Free PMC Article | 10/26/2019 |
| Study identified an inner activation gate, which is established by three hydrophobic residues, F518, Y563 and I612, in the middle of the phospholipid permeation pathway of TMEM16F-CaPLSase. Disrupting the inner gate profoundly alters TMEM16F phospholipid permeation. | An inner activation gate controls TMEM16F phospholipid scrambling.
Le T, Jia Z, Le SC, Zhang Y, Chen J, Yang H., Free PMC Article | 06/15/2019 |
| We conclude that ANO6, by virtue of its scramblase activity, may play a role as an important regulator of the ADAM-network in the plasma membrane. | Anoctamin-6 regulates ADAM sheddase function.
Veit M, Koyro KI, Ahrens B, Bleibaum F, Munz M, Rövekamp H, Andrä J, Schreiber R, Kunzelmann K, Sommer A, Bhakdi S, Reiss K. | 05/25/2019 |
| Both inactivating and activating mutants that elucidate the mechanism for TMEM16F activation. | Chemically induced vesiculation as a platform for studying TMEM16F activity.
Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY., Free PMC Article | 03/30/2019 |
| ANO6 current shows sluggish activation even with high [Ca2+]i, and inactivation. Actin cytoskeleton disruption accelerate both activation and inactivation of ANO6. Intracellular MgATP further delays ANO6 activation, and prevent inactivation. | TMEM16F/ANO6, a Ca(2+)-activated anion channel, is negatively regulated by the actin cytoskeleton and intracellular MgATP.
Lin H, Roh J, Woo JH, Kim SJ, Nam JH. | 01/19/2019 |
| The authorsreport the first association in two sisters of a deletion and a nonsense variation explaining the pathophysiology of Scott syndrome. | A new mutation of ANO6 in two familial cases of Scott syndrome.
Boisseau P, Bene MC, Besnard T, Pachchek S, Giraud M, Talarmain P, Robillard N, Gourlaouen MA, Bezieau S, Fouassier M. | 01/5/2019 |
| ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6. | Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells.
Banerjee J, Leung CT, Li A, Peterson-Yantorno K, Ouyang H, Stamer WD, Civan MM., Free PMC Article | 06/24/2017 |
| TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways. | TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells.
Schenk LK, Schulze U, Henke S, Weide T, Pavenstädt H. | 02/18/2017 |
| Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms | Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms.
Scudieri P, Caci E, Venturini A, Sondo E, Pianigiani G, Marchetti C, Ravazzolo R, Pagani F, Galietta LJ., Free PMC Article | 07/2/2016 |
| deficiency in Ano6 resulted in reduced viability with increased bleeding time | Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.
Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW. | 06/28/2016 |
| ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. | Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation.
Forschbach V, Goppelt-Struebe M, Kunzelmann K, Schreiber R, Piedagnel R, Kraus A, Eckardt KU, Buchholz B., Free PMC Article | 06/28/2016 |
| facilitates transbilayer migration of lipids [review] | Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane.
Bevers EM, Williamson PL. | 06/28/2016 |