| RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs. | RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs.
Xiao L, Qiao J, Huang Y, Tan B, Hong L, Li Z, Cai G, Wu Z, Zheng E, Wang S, Gu T., Free PMC Article | 04/5/2024 |
| Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling. | Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD., Free PMC Article | 09/8/2023 |
| RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth. | RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.
Wang C, Li X, Xue B, Yu C, Wang L, Deng R, Liu H, Chen Z, Zhang Y, Fan S, Zuo C, Sun H, Zhu H, Wang J, Tang S., Free PMC Article | 11/26/2022 |
| Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. | Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J., Free PMC Article | 12/4/2021 |
| Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation. | Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.
Oh M, Kim SY, Gil JE, Byun JS, Cha DW, Ku B, Lee W, Kim WK, Oh KJ, Lee EW, Bae KH, Lee SC, Han BS., Free PMC Article | 01/9/2021 |
| Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis. | Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
Karra L, Romero-Moya D, Ksionda O, Krush M, Gu Z, Mues M, Depeille P, Mullighan C, Roose JP., Free PMC Article | 12/12/2020 |
| RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. | RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P., Free PMC Article | 10/24/2020 |
| this study indicates a mechanism for the association of RasGRP1 deficiency with predispostion to infection in the loss of a particular B1a lymphocyte subpopulation. | Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice.
Guo B, Ludlow AV, Brightwell AS, Rothstein TL. | 06/6/2020 |
| this study shows that TGF-beta suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis | TGF-β suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis.
Takami M, Cunha C, Motohashi S, Nakayama T, Iwashima M., Free PMC Article | 05/25/2019 |
| guanine nucleotide exchange factor RasGRP1 inhibited Rhes-mediated control of striatal motor activity in mice. RasGRP1 stabilized Rhes, increasing its synaptic accumulation in the striatum. | RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S., Free PMC Article | 11/25/2017 |
| signaling underpins thymic selection processes induced by both weak and strong TCR signals and is differentially required for fate decisions derived from a strong TCR stimulus | Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development.
Golec DP, Hoeppli RE, Henao Caviedes LM, McCann J, Levings MK, Baldwin TA., Free PMC Article | 09/30/2017 |
| RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 ligand, CCL25, suggesting that RasGRP1 and RasGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism. | RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors.
Golec DP, Henao Caviedes LM, Baldwin TA. | 08/5/2017 |
| RasGRP1 is indispensable for development of B1a cells with autoantigen receptors, revealing a connection between a signaling molecule and development of a specific repertoire within the B1a cell population | RasGRP1 Is an Essential Signaling Molecule for Development of B1a Cells with Autoantigen Receptors.
Guo B, Rothstein TL., Free PMC Article | 08/13/2016 |
| Genetic Rasgrp1 depletion from mice with either an activating mutation in KRas or with aberrant Wnt signalling due to a mutation in Apc resulted in both cases in exacerbated Ras-ERK signalling and cell proliferation. | RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP., Free PMC Article | 09/5/2015 |
| CD44 expression, CD4(+) T cell subset ratios and serum autoantibodies all returned to normal in Rasgrp1(Anaef)Mtor(chino) double-mutant mice | Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.
Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP., Free PMC Article | 03/7/2015 |
| RasGRP1 upregulates signaling from Ras and contributes to epidermal tumorigenesis by increasing the total dosage of active Ras. | Targeted deletion of RasGRP1 impairs skin tumorigenesis.
Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS., Free PMC Article | 06/28/2014 |
| autoreactive B cells lacking Rasgrp1 break central and peripheral tolerance through both T cell-independent and -dependent mechanisms. | Multiple checkpoint breach of B cell tolerance in Rasgrp1-deficient mice.
Bartlett A, Buhlmann JE, Stone J, Lim B, Barrington RA. | 11/30/2013 |
| Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. | Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP., Free PMC Article | 09/14/2013 |
| RasGRP1, but not RasGRP3, is required for thymocyte positive selection and invariant natural killer T cell selection. | RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.
Golec DP, Dower NA, Stone JC, Baldwin TA., Free PMC Article | 07/6/2013 |
| Genetic analysis shows that disease progression and ERK signaling are dependent on RAS guanine exchange factor responsible for ERK activation and lymphoproliferative phenotype in LAT-Y136F mutant mice. | A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL., Free PMC Article | 03/16/2013 |
| While the DAG-binding C1 domain of RasGRP1 has long been recognized as an important factor mediating Erk activation, we have revealed the physiological relevance of the tail domain in RasGRP1 function and control of Erk signaling | Regulation of RasGRP1 function in T cell development and activation by its unique tail domain.
Fuller DM, Zhu M, Song X, Ou-Yang CW, Sullivan SA, Stone JC, Zhang W., Free PMC Article | 12/22/2012 |
| assessed the independent and combined roles for the RasGEFs Sos1, Sos2, and RasGRP1 during thymocyte development | Deconstructing Ras signaling in the thymus.
Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE., Free PMC Article | 09/22/2012 |
| RasGRP1 plays differential roles for gammadelta and alphabeta T cell development but is critical for gammadeltaT cell proliferation and production of IL-17. | Differential requirement of RasGRP1 for γδ T cell development and activation.
Chen Y, Ci X, Gorentla B, Sullivan SA, Stone JC, Zhang W, Pereira P, Lu J, Zhong XP., Free PMC Article | 09/8/2012 |
| RasGRP1 is important not only for early invariant natural killer (NK)T cell development but also for the generation and maintenance of CD4-positive NKT cells. | Critical roles of RasGRP1 for invariant NKT cell development.
Shen S, Chen Y, Gorentla BK, Lu J, Stone JC, Zhong XP., Free PMC Article | 01/28/2012 |
| Gene silencing of Ras-GRP1 prevented the PTH-mediated suppression of NCC activity, the activation of the H-Ras isoform of Ras, and the activation of ERK1/2 MAPK | Parathyroid hormone (PTH) regulates the sodium chloride cotransporter via Ras guanyl releasing protein 1 (Ras-GRP1) and extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein kinase (MAPK) pathway.
Ko B, Cooke LL, Hoover RS., Free PMC Article | 12/10/2011 |