| GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina. | GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina.
Jimeno D, Lillo C, de la Villa P, Calzada N, Santos E, Fernández-Medarde A., Free PMC Article | 11/15/2023 |
| Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent. | Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent.
Olevska A, Spanagel R, Bernardi RE. | 01/29/2022 |
| Cocaine self administration in RasGRF2 KO mice was increased relative to WT controls, whereas RasGRF1 KO and WT mice did not differ. RasGRF2 mediates cocaine self-administration via an ERK-dependent mechanism, whereas RasGRF1 has no effect on responding for cocaine. | The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.
Bernardi RE, Olevska A, Morella I, Fasano S, Santos E, Brambilla R, Spanagel R., Free PMC Article | 06/27/2020 |
| Nuclear migration in retinal cone photoreceptors is altered in GRF2 knockout mice. | RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
Jimeno D, Gómez C, Calzada N, de la Villa P, Lillo C, Santos E. | 12/17/2016 |
| adaptations in the noradrenergic system contribute to the Rasgrf2 enhanced risk of alcoholism. | Rasgrf2 controls noradrenergic involvement in the acute and subchronic effects of alcohol in the brain.
Easton AC, Rotter A, Lourdusamy A, Desrivières S, Fernández-Medarde A, Biermann T, Fernandes C, Santos E, Kornhuber J, Schumann G, Müller CP. | 10/17/2015 |
| Findings indicate that GRF2 regulates both the basal level and environmentally induced increase of newborn neuron survival, as well as in the induction of a distinct form of synaptic plasticity of newborn neurons that contributes to learning and memory | Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus.
Darcy MJ, Trouche S, Jin SX, Feig LA., Free PMC Article | 07/25/2015 |
| These data suggest that Rasgrf2 controls dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens. | Rasgrf2 controls dopaminergic adaptations to alcohol in mice.
Easton AC, Rotter A, Lourdusamy A, Desrivières S, Fernández-Medarde A, Biermann T, Fernandes C, Santos E, Kornhuber J, Schumann G, Müller CP. | 07/25/2015 |
| these results suggest that betaarrestin1 regulates rasgrf2 gene expression and Rac activation to affect membrane protrusion and cell migration and invasion. | βArrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility.
Ma X, Espana-Serrano L, Kim WJ, Thayele Purayil H, Nie Z, Daaka Y., Free PMC Article | 06/28/2014 |
| Ras-GRF1 and -GRF2 may act as adaptors that bind PLCgamma1 and restrict Ca2+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 induction of the Ras-->ERK pathway and MMP-3 expression | Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
Wang Q, Siminovitch KA, Downey GP, McCulloch CA. | 03/9/2013 |
| RASGRF2 has a role in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse | RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release.
Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, Flor H, Gallinat J, Garavan H, Bokde AL, Heinz A, Ittermann B, Lathrop M, Lawrence C, Loth E, Lourdusamy A, Mann KF, Martinot JL, Nees F, Palkovits M, Paus T, Pausova Z, Rietschel M, Ruggeri B, Santos E, Smolka MN, Staehlin O, Jarvelin MR, Elliott P, Sommer WH, Mameli M, Müller CP, Spanagel R, Girault JA, Schumann G, IMAGEN Consortium., Free PMC Article | 03/2/2013 |
| Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. | RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P. | 09/10/2011 |
| Study demonstrates that NR2A-, but not NR2B, containing NMDA receptors induce LTP in pyramidal neurons of the CA1 hippocampus from 1 month old mice through Ras-GRF2 and Erk. | Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.
Jin SX, Feig LA., Free PMC Article | 10/30/2010 |
| These data reveal unexpected negative roles for Vav1 and RasGRF2 in different stages of T-cell lymphoma progression. | The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Ruiz S, Santos E, Bustelo XR., Free PMC Article | 03/22/2010 |
| These results identify RasGRF2 as an additional component of the signaling machinery involved in T-cell receptor- and NF-AT-mediated immune responses. | RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.
Ruiz S, Santos E, Bustelo XR., Free PMC Article | 01/21/2010 |
| Mediates forms of synaptic plasticity by coupling different classes of NMDA receptors to distinct MAP kinase pathways | Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.
Li S, Tian X, Hartley DM, Feig LA., Free PMC Article | 01/21/2010 |
| Data show that Ras-GRF1 and Ras-GRF2 couple NMDA glutamate receptors to the activation of the Ras/Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice. | Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.
Tian X, Gotoh T, Tsuji K, Lo EH, Huang S, Feig LA., Free PMC Article | 01/21/2010 |