| MicroRNA-125a-5p modulates the proliferation and apoptosis of TM4 Sertoli cells by targeting RAB3D and regulating the PI3K/AKT signaling pathway. | MicroRNA-125a-5p modulates the proliferation and apoptosis of TM4 Sertoli cells by targeting RAB3D and regulating the PI3K/AKT signaling pathway.
Teng F, Hu F, Zhang M. | 01/29/2022 |
| Loss of Rab3D from secretory vesicles, leading to disproportionate Rab27-to-Rab3D activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome. | Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome.
Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF., Free PMC Article | 06/3/2017 |
| Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2) are equally able to bind to small GTPases Rab3D (Rab3d GTPase) and RagA (Ras-related GTP binding A). | DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor.
Merino-Gracia J, García-Mayoral MF, Rapali P, Valero RA, Bruix M, Rodríguez-Crespo I. | 04/30/2016 |
| Acute expression of Rab1 and Rab3d DN constructs partially alleviated this negative feedback mechanism and resulted in impaired ER to Golgi trafficking of procollagen. | Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts.
Nabavi N, Pustylnik S, Harrison RE., Free PMC Article | 04/13/2013 |
| Targeted disruption of Tctex-1 by RNA interference significantly impairs bone resorption capacity and mislocalizes Rab3D vesicles in osteoclasts. | Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.
Pavlos NJ, Cheng TS, Qin A, Ng PY, Feng HT, Ang ES, Carrello A, Sung CH, Jahn R, Zheng MH, Xu J., Free PMC Article | 05/21/2011 |
| MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. | RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.
Tian X, Jin RU, Bredemeyer AJ, Oates EJ, Błazewska KM, McKenna CE, Mills JC., Free PMC Article | 03/29/2010 |
| Novel localization of pIgR to the regulated secretory pathway of lacrimal gland acinar cells and its secretion therefrom may be affected by its novel interaction with Rab3D. | Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells.
Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT., Free PMC Article | 01/21/2010 |
| Data suggest that Rab3D modulates a post-trans-Golgi network trafficking step that is required for osteoclastic bone resorption. | Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption.
Pavlos NJ, Xu J, Riedel D, Yeoh JS, Teitelbaum SL, Papadimitriou JM, Jahn R, Ross FP, Zheng MH., Free PMC Article | 01/21/2010 |
| Rab3D has a role in binding GTP in pancreatic acini | Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini.
Chen X, Ernst SA, Williams JA. | 01/21/2010 |
| Rab3D is not required for exocrine exocytosis but for maintenance of secretory granules size. | Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules.
Riedel D, Antonin W, Fernandez-Chacon R, Alvarez de Toledo G, Jo T, Geppert M, Valentijn JA, Valentijn K, Jamieson JD, Südhof TC, Jahn R., Free PMC Article | 01/21/2010 |
| Rab3D plays an important role in regulating the terminal steps of acinar exocytosis and this effect is greatest on the early phase of amylase release. | Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini.
Chen X, Edwards JA, Logsdon CD, Ernst SA, Williams JA. | 01/21/2010 |
| Rab3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range. | Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.
Schlüter OM, Basu J, Südhof TC, Rosenmund C., Free PMC Article | 01/21/2010 |