| SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression. | SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression.
Wang M, Ding Y, Hu Y, Li Z, Luo W, Liu P, Li Z., Free PMC Article | 05/28/2023 |
| Pre-meiotic deletion of PEX5 causes spermatogenesis failure and infertility in mice. | Pre-meiotic deletion of PEX5 causes spermatogenesis failure and infertility in mice.
Liu M, Liu S, Song C, Zhu H, Wu B, Zhang A, Zhao H, Wen Z, Gao J., Free PMC Article | 03/6/2023 |
| Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5. | Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5.
Werner ER, Swinkels D, Juric V, Dorninger F, Baes M, Keller MA, Berger J, Watschinger K. | 02/4/2023 |
| Aging lowers PEX5 levels in cortical neurons in male and female mouse brains. | Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.
Uzor NE, Scheihing DM, Kim GS, Moruno-Manchon JF, Zhu L, Reynolds CR, Stephenson JM, Holmes A, McCullough LD, Tsvetkov AS., Free PMC Article | 07/31/2021 |
| A Novel FRET Approach Quantifies the Interaction Strength of Peroxisomal Targeting Signals and Their Receptor in Living Cells. | A Novel FRET Approach Quantifies the Interaction Strength of Peroxisomal Targeting Signals and Their Receptor in Living Cells.
Hochreiter B, Chong CS, Hartig A, Maurer-Stroh S, Berger J, Schmid JA, Kunze M., Free PMC Article | 06/19/2021 |
| A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. | A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.
Ali M, Khan SY, Rodrigues TA, Francisco T, Jiao X, Qi H, Kabir F, Irum B, Rauf B, Khan AA, Mehmood A, Naeem MA, Assir MZ, Ali MH, Shahzad M, Abu-Amero KK, Akram SJ, Akram J, Riazuddin S, Riazuddin S, Robinson ML, Baes M, Azevedo JE, Hejtmancik JF, Riazuddin SA. | 05/15/2021 |
| Association of Hsd17b4 with ceramide-enriched mitochondria-associated membranes prevents its interaction with peroxisomal import protein Pex5 at peroxisomes. | Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes.
Zhu Z, Chen J, Wang G, Elsherbini A, Zhong L, Jiang X, Qin H, Tripathi P, Zhi W, Spassieva SD, Morris AJ, Bieberich E., Free PMC Article | 03/7/2020 |
| monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery | Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.
Nordgren M, Francisco T, Lismont C, Hennebel L, Brees C, Wang B, Van Veldhoven PP, Azevedo JE, Fransen M., Free PMC Article | 06/28/2016 |
| Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice. | Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system.
Bottelbergs A, Verheijden S, Van Veldhoven PP, Just W, Devos R, Baes M., Free PMC Article | 06/15/2013 |
| interaction of PEX5 with catalase and PEX14 | PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.
Freitas MO, Francisco T, Rodrigues TA, Alencastre IS, Pinto MP, Grou CP, Carvalho AF, Fransen M, Sá-Miranda C, Azevedo JE., Free PMC Article | 01/21/2012 |
| Absence of peroxisomal metabolism in neurons and astrocytes does not provoke the neurodegenerative phenotype observed after deleting peroxisomes from oligodendrocytes. Lack of peroxisomal metabolism in astrocytes causes increased VLCFA levels in myelin | Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes.
Bottelbergs A, Verheijden S, Hulshagen L, Gutmann DH, Goebbels S, Nave KA, Kassmann C, Baes M. | 12/4/2010 |
| Peroxisomes were selectively reconstituted in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome, by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a correction of the neuronal migration defect | Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues.
Janssen A, Gressens P, Grabenbauer M, Baumgart E, Schad A, Vanhorebeek I, Brouwers A, Declercq PE, Fahimi D, Evrard P, Schoonjans L, Collen D, Carmeliet P, Mannaerts G, Van Veldhoven P, Baes M., Free PMC Article | 01/21/2010 |