Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L.

Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
Hata K, Tsubouchi K, Suzuki K, Eto D, Ando H, Yanagihara T, Kan-O K, Okamoto I., Free PMC Article

SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
Wang B, Pan L, Chen M, Ma Y, Gao J, Tang D, Jiang Z.

Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.
Lysenko V, Schürch PM, Tuzlak S, van Wijk NW, Kovtonyuk LV, Becher B, Manz MG, Kreutmair S, Theocharides APA., Free PMC Article

Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
Jiang D, Burger CA, Akhanov V, Liang JH, Mackin RD, Albrecht NE, Andrade P, Schafer DP, Samuel MA., Free PMC Article

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
Wang D, Lin Y, Xu F, Zhang H, Zhu X, Liu Z, Hu Y, Dong G, Sun B, Yu Y, Ma G, Tang Z, Legarda D, Ting A, Liu Y, Hou J, Dong L, Xiong H., Free PMC Article

SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
Thomas SS, Wu J, Davogustto G, Holliday MW, Eckel-Mahan K, Verzola D, Garibotto G, Hu Z, Mitch WE, Taegtmeyer H., Free PMC Article

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
Ren B, Xia H, Liao Y, Zhou H, Wang Z, Shi Y, Zhu M., Free PMC Article

SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
Autio A, Wang H, Velázquez F, Newton G, Parkos CA, Engel P, Engelbertsen D, Lichtman AH, Luscinskas FW., Free PMC Article

Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.
Wang SK, Xue Y, Cepko CL., Free PMC Article

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
De Vlaminck K, Romão E, Puttemans J, Pombo Antunes AR, Kancheva D, Scheyltjens I, Van Ginderachter JA, Muyldermans S, Devoogdt N, Movahedi K, Raes G., Free PMC Article

Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons.
Jingu D, Iino M, Kawasaki J, Urano E, Kusakari S, Hayashi Y, Matozaki T, Ohnishi H.

The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer.
Wang X, Luo X, Chen C, Tang Y, Li L, Mo B, Liang H, Yu S., Free PMC Article

The SIRPα-CD47 immune checkpoint in NK cells.
Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S., Free PMC Article

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.
Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR., Free PMC Article

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.
Bian Z, Shi L, Kidder K, Zen K, Garnett-Benson C, Liu Y., Free PMC Article

SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production.
Franke K, Pillai SY, Hoogenboezem M, Gijbels MJJ, Matlung HL, Geissler J, Olsman H, Pottgens C, van Gorp PJ, Ozsvar-Kozma M, Saito Y, Matozaki T, Kuijpers TW, Hendriks RW, Kraal G, Binder CJ, de Winther MPJ, van den Berg TK., Free PMC Article

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.
Ding X, Wang J, Huang M, Chen Z, Liu J, Zhang Q, Zhang C, Xiang Y, Zen K, Li L., Free PMC Article

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Morrissey MA, Kern N, Vale RD., Free PMC Article

Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.
Kidder K, Bian Z, Shi L, Liu Y., Free PMC Article

HSF1 promotes the viability of islet β-cells via upregulating SIRPα expression.
Zhang HM, Yang M, Zhang XY, Tang Y, Wu JL, Huang J.

Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.
Gauttier V, Pengam S, Durand J, Biteau K, Mary C, Morello A, Néel M, Porto G, Teppaz G, Thepenier V, Danger R, Vince N, Wilhelm E, Girault I, Abes R, Ruiz C, Trilleaud C, Ralph K, Trombetta ES, Garcia A, Vignard V, Martinet B, Glémain A, Bruneau S, Haspot F, Dehmani S, Duplouye P, Miyasaka M, Labarrière N, Laplaud D, Le Bas-Bernardet S, Blanquart C, Catros V, Gouraud PA, Archambeaud I, Aublé H, Metairie S, Mosnier JF, Costantini D, Blancho G, Conchon S, Vanhove B, Poirier N., Free PMC Article

SIRPα on CD11c(+) cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis.
Nishimura T, Saito Y, Washio K, Komori S, Respatika D, Kotani T, Murata Y, Ohnishi H, Mizobuchi S, Matozaki T.

Signal regulatory protein α protects podocytes through promoting autophagic activity.
Li L, Liu Y, Li S, Yang R, Zeng C, Rong W, Liang H, Zhang M, Zhu X, Kidder K, Liu Y, Liu Z, Zen K., Free PMC Article

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.
Elberg G, Liraz-Zaltsman S, Reichert F, Matozaki T, Tal M, Rotshenker S., Free PMC Article