| Mechanisms of mGluR-dependent plasticity in hippocampal area CA2. | Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
Samadi M, Hales CA, Lustberg DJ, Farris S, Ross MR, Zhao M, Hepler JR, Harbin NH, Robinson ESJ, Banks PJ, Bashir ZI, Dudek SM., Free PMC Article | 05/31/2023 |
| Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology. | Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.
Taylor D, Kneynsberg A, van Roijen M, Götz J., Free PMC Article | 01/21/2023 |
| Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner. | Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP(61)) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.
Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J., Free PMC Article | 12/11/2021 |
| Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP. | Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
Rajagopal S, Yang C, DeMars KM, Poddar R, Candelario-Jalil E, Paul S., Free PMC Article | 06/12/2021 |
| Levels of Ptpn5 protein are elevated in a mouse model of sepsis-associated encephalopathy with associated decreases in phosphorylated forms of GluN2B, CREB, PSD95, ERK1, BDNF, and ERK2. | Disruption of Striatal-Enriched Protein Tyrosine Phosphatase Signaling Might Contribute to Memory Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.
Zong MM, Yuan HM, He X, Zhou ZQ, Qiu XD, Yang JJ, Ji MH. | 04/4/2020 |
| Deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of Huntington's disease. | Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.
García-Forn M, Martínez-Torres S, García-Díaz Barriga G, Alberch J, Milà M, Azkona G, Pérez-Navarro E. | 09/7/2019 |
| STEP61 undergoes proteolytic degradation in conditions leading to synaptic strengthening and memory formation | Proteolytic Degradation of Hippocampal STEP(61) in LTP and Learning.
Saavedra A, Ballesteros JJ, Tyebji S, Martínez-Torres S, Blázquez G, López-Hidalgo R, Azkona G, Alberch J, Martín ED, Pérez-Navarro E. | 07/13/2019 |
| activation of synaptic NMDAR by bicuculline or D-serine results in the ubiquitination and proteasomal degradation of STEP61, and increased surface localization of GluN1/GluN2B receptors. | Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61).
Xu J, Kurup P, Nairn AC, Lombroso PJ., Free PMC Article | 03/2/2019 |
| STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release. | Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.
Bosco F, Valente P, Milanese M, Piccini A, Messa M, Bonanno G, Lombroso P, Baldelli P, Benfenati F, Giovedì S. | 12/22/2018 |
| STEP61 degradation is an important event in BDNF-mediated effects. | BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.
Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E., Free PMC Article | 01/20/2018 |
| STEP has a key role in the regulation of psychomotor action and physical dependency to morphine. These data suggest that STEP inhibition may be a critical target for the treatment of withdrawal symptoms associated with morphine. | STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance.
Kim YJ, Kang Y, Park HY, Lee JR, Yu DY, Murata T, Gondo Y, Hwang JH, Kim YH, Lee CH, Rhee M, Han PL, Chung BH, Lee HJ, Kim KS., Free PMC Article | 10/22/2016 |
| This study demonistrated that behavioral, molecular, and electrophysiological data indicate that spinal STEP61 plays a regulatory role in nociception. | Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.
Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E., Free PMC Article | 10/22/2016 |
| STEP61 regulates BDNF expression, with implications for cognitive functioning in CNS disorders. | Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.
Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ., Free PMC Article | 07/30/2016 |
| The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2. | Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.
Poddar R, Rajagopal S, Shuttleworth CW, Paul S., Free PMC Article | 05/21/2016 |
| STEP contributes, at least in part, to the protection against the ingestion of aversive agents. | Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.
Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D., Free PMC Article | 04/23/2016 |
| These results indicate that STEP61 is a novel substrate of parkin, although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD. | STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC., Free PMC Article | 04/25/2015 |
| Abeta regulating STEP61 activity is mediated by Abeta binding to alpha7 nAChRs | Tyrosine phosphatase STEP61 negatively regulates amyloid β-mediated ERK/CREB signaling pathways via α7 nicotinic acetylcholine receptors.
Zhang L, Xie JW, Yang J, Cao YP. | 06/21/2014 |
| Increased STEP and calpain activation contribute to altered NMDAR localization in an Huntington's disease mouse model. | Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.
Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA., Free PMC Article | 12/22/2012 |
| genetically reducing STEP significantly diminishes seizures and restores select social and nonsocial anxiety-related behaviors in Fmr1(KO) mice | Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.
Goebel-Goody SM, Wilson-Wallis ED, Royston S, Tagliatela SM, Naegele JR, Lombroso PJ., Free PMC Article | 11/24/2012 |
| the first study to identify Pyk2 as a substrate for STEP. | Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.
Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ., Free PMC Article | 08/25/2012 |
| Increased STEP61 plays a role in amyloid Abeta-mediated internalization of the (AMPAR) subunits GluA1/GluA2 (formerly GluR1/GluR2). | Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.
Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ., Free PMC Article | 12/3/2011 |
| The absence of STEP improves cognitive performance, and may do so by the regulation of downstream effectors necessary for synaptic transmission. | Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory.
Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ., Free PMC Article | 10/29/2011 |
| STEP pathway is severely downregulated in the presence of mutant huntingtin and may participate in compensatory mechanisms activated by striatal neurons that lead to resistance to excitotoxicity. | Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.
Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E., Free PMC Article | 08/27/2011 |
| STEP may be required for ethanol's amnesic effects. | Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.
Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD., Free PMC Article | 06/18/2011 |
| Electrical stimulation of the hippocampal-entorhinal cortex pathway in STEP knockout mice resulted in less activation of the dentate gyrus granule cell layer (GCL), but greater activation of the hilus in STEP knockouts, compared with heterozygous slices. | STEP regulation of seizure thresholds in the hippocampus.
Briggs SW, Walker J, Asik K, Lombroso P, Naegele J, Aaron G., Free PMC Article | 05/14/2011 |