SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson MC, Santos LN, Le Sommer S, Fang B, Koomen JM, Seeliger M, Qu CK, Yart A, Kontaridis MI, Mahajan K, Mahajan NP., Free PMC Article

MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
Perrin S, Protic S, Bretegnier V, Laurendeau I, de Lageneste OD, Panara N, Ruckebusch O, Luka M, Masson C, Maillard T, Coulpier F, Pannier S, Wicart P, Hadj-Rabia S, Radomska KJ, Zarhrate M, Ménager M, Vidaud D, Topilko P, Parfait B, Colnot C.

Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation.
Han X, Wei J, Zheng R, Tu Y, Wang M, Chen L, Xu Z, Zheng L, Zheng C, Shi Q, Ying H, Liang G.

The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice.
Liu M, Fu D, Gao T, Jiang H, Yang P, Li X., Free PMC Article

Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis.
Li T, Xu B, Li W, Cheng X, Tantai W, Zheng H, Zhao L, Li N, Han C.

Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution.
Liu M, Ji M, Cheng J, Li Y, Tian Y, Zhao H, Wang Y, Zhu S, Zhang L, Xu X, Feng GS, Liang X, Bao H, Tang Y, Kong S, Lu J, Wang H, Lu Z, Deng W., Free PMC Article

Hepatic protein tyrosine phosphatase Shp2 disruption mitigates the adverse effects of ethanol in the liver by modulating oxidative stress and ERK signaling.
Hsu MF, LeBleu G, Flores L, Parkhurst A, Nagy LE, Haj FG.

SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.
Hou B, Hu Y, Zhu Y, Wang X, Li W, Tang J, Jia X, Wang J, Cong Y, Quan M, Yang H, Zheng H, Bao Y, Chen XL, Wang HR, Xu B, Gascoigne NRJ, Fu G.

Protein Tyrosine Phosphatase SHP2 in Macrophages Acts as an Antiatherosclerotic Regulator in Mice.
Wu C, Zheng P, Ma L, Xu C, Hu L, Yang Z, Fei F, Shen Z, Zhang X, Wu Z, Cheng H, Mao W, Ke Y.

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation.
Gao Q, Lu Y, Zhou W., Free PMC Article

Deletion of PDK(1) Caused Cardiac Malmorphogenesis and Heart Defects Due to Profound Protein Phosphorylation Changes Mediated by SHP(2).
Luo H, Yang Z, Li J, Jin H, Jiang M, Shan C.

Long non-coding RNA MM2P suppresses M1-polarized macrophages-mediated excessive inflammation to prevent sodium taurocholate-induced acute pancreatitis by blocking SHP2-mediated STAT3 dephosphorylation.
Peng K, Biao C, Zhao YY, Jun LC, Wei W, A Bu Li Zi YLNYZ, Song L.

Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia.
Pasupuleti SK, Chao K, Ramdas B, Kanumuri R, Palam LR, Liu S, Wan J, Annesley C, Loh ML, Stieglitz E, Burke MJ, Kapur R., Free PMC Article

Neuronal Ptpn1 and Socs3 deletion improves metabolism but not anovulation in a mouse polycystic ovary syndrome model.
Kerbus RI, Inglis MA, Anderson GM.

LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
Li Y, Guo J, Zhang H, Li Z, Ren Y, Jiang Y, Liu X, Hu X., Free PMC Article

Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals.
Wu X, Guan S, Lu Y, Xue J, Yu X, Zhang QI, Wang X, Li T., Free PMC Article

SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor.
Chen L, Zhao W, Li M, Yang Y, Tian C, Zhang D, Chang Z, Zhang Y, Zhao ZJ, Chen Y, Ma L., Free PMC Article

Knockdown of SHP2 attenuated LPS-induced ferroptosis via downregulating ACSL4 expression in acute lung injury.
Li B, Wang Z, Yuan J, Liang D, Cheng Y, Wang Z.

G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2.
Bono F, Tomasoni Z, Mutti V, Sbrini G, Kumar R, Longhena F, Fiorentini C, Missale C., Free PMC Article

The Cell-Specific Role of SHP2 in Regulating Bone Homeostasis and Regeneration Niches.
Zhang J, Ye C, Zhu Y, Wang J, Liu J., Free PMC Article

Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling.
Wei X, Zheng L, Tian Y, Wang H, Su Y, Feng G, Wang C, Lu Z., Free PMC Article

Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia.
Hsu MF, Ito Y, Afkarian M, Haj FG., Free PMC Article

α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes.
Tseng CC, Zheng RH, Lin TW, Chou CC, Shih YC, Liang SW, Lee HH., Free PMC Article

PD-1 Suppresses the Osteogenic and Odontogenic Differentiation of Stem Cells from Dental Apical Papilla via Targeting SHP2/NF-κB Axis.
Li N, Li Z, Fu L, Yan M, Wang Y, Yu J, Wu J.

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation.
Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D, Seifert U., Free PMC Article