| The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc<sup>Min/+</sup> mice. | The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc(Min/+) mice.
Bruno A, Contursi A, Tacconelli S, Sacco A, Hofling U, Mucci M, Lamolinara A, Del Pizzo F, Ballerini P, Di Gregorio P, Yu Y, Patrignani P. | 11/12/2022 |
| Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. | Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation.
Mitchell JA, Shala F, Pires MEL, Loy RY, Ravendren A, Benson J, Urquhart P, Nicolaou A, Herschman HR, Kirkby NS., Free PMC Article | 04/23/2022 |
| Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback. | Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback.
Haidey JN, Peringod G, Institoris A, Gorzo KA, Nicola W, Vandal M, Ito K, Liu S, Fielding C, Visser F, Nguyen MD, Gordon GR. | 02/12/2022 |
| Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases. | Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases.
Makabe K, Sugita S, Futatsugi Y, Takahashi M., Free PMC Article | 06/12/2021 |
| Exposure to growth hormone is associated with hepatic up-regulation of cPLA2alpha and COX. | Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX.
Piazza VG, Matzkin ME, Cicconi NS, Muia NV, Valquinta S, Mccallum GJ, Micucci GP, Freund T, Zotta E, González L, Frungieri MB, Fang Y, Bartke A, Sotelo AI, Miquet JG., Free PMC Article | 05/29/2021 |
| PTGS1-modified cells were incubated with synthograft and transplanted into the dorsal space of mice. .. HE staining showed that the PTGS1sh group generated much more bone-like tissue compared with the NC group , and quantitative analysis verified that silencing of PTGS1 greatly promoted bone-like tissue formation in vivo | Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling.
Wang Y, Liu Y, Zhang M, Lv L, Zhang X, Zhang P, Zhou Y., Free PMC Article | 05/9/2020 |
| Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice | Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.
Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P. | 01/4/2020 |
| Transgenic mice study revealed that knock-in COX-1 failed to substitute for the loss of COX-2 in COX-1>COX-2 mice during implantation, indicating that COX-1 may be replaced by COX-2, but not vice versa. A panel of prostaglandins detected in uterus and ovary demonstrates that prostaglandin biosynthesis preferentially depends on native COX-1, but not COX-2. | Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.
Li X, Ballantyne LL, Crawford MC, FitzGerald GA, Funk CD., Free PMC Article | 11/2/2019 |
| Expression of COX-1 and production of thromboxane A2 in platelets of STZ-induced diabetic mice were elevated. | Effects of three-month streptozotocin-induced diabetes in mice on blood platelet reactivity, COX-1 expression and adhesion potential.
Przygodzki T, Kassassir H, Talar M, Siewiera K, Watala C., Free PMC Article | 07/13/2019 |
| Manipulation of COXs 1 & 2 revealed isoform-specific compensatory functions and variable degrees of interchangeability for PG biosynthesis in cells/tissues | Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.
Li X, Mazaleuskaya LL, Yuan C, Ballantyne LL, Meng H, Smith WL, FitzGerald GA, Funk CD., Free PMC Article | 05/25/2019 |
| the highly expressed knockin COX-2 enzyme barely makes any PGs or thromboxane in neonatal P8 or adult mice, demonstrating that prostanoid biosynthesis requires native COX-1 and cannot be rescued by the knockin COX-2. In summary, the 2 COX isoforms can preferentially compensate for some renal functions, which appears to be independent of the PG-synthetic capacity. | Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.
Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD., Free PMC Article | 04/6/2019 |
| IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis. | Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E(2).
Newson J, Motwani MP, Kendall AC, Nicolaou A, Muccioli GG, Alhouayek M, Bennett M, Van De Merwe R, James S, De Maeyer RPH, Gilroy DW., Free PMC Article | 06/30/2018 |
| Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions. | Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility.
Herington JL, O'Brien C, Robuck MF, Lei W, Brown N, Slaughter JC, Paria BC, Mahadevan-Jansen A, Reese J., Free PMC Article | 02/24/2018 |
| Data suggest that Il4 (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 = interleukin-4; Cox1 = cyclooxygenase 1; Ampk = AMP-activated protein kinase) | IL-4 up-regulates cyclooxygenase-1 expression in macrophages.
Shay AE, Diwakar BT, Guan BJ, Narayan V, Urban JF Jr, Prabhu KS., Free PMC Article | 09/30/2017 |
| Specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections. | Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P., Free PMC Article | 05/20/2017 |
| Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase. | Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.
Joshi V, Umashankara M, Ramakrishnan C, Nanjaraj Urs AN, Suvilesh KN, Velmurugan D, Rangappa KS, Vishwanath BS. | 04/29/2017 |
| role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas | Role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas.
Li S, Liu B, Luo W, Zhang Y, Li H, Huang D, Zhou Y. | 10/22/2016 |
| Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation. | Effects of Cyclooxygenase on the Urothelium of the Urinary Bladder of Mice Exposed to Pelvic Radiation.
Ozbilgin MK, Onal T, Ozcan C, Temel M, Aktas C, Gareveran MS, Uluer ET, Inan S, Kurtman C. | 08/13/2016 |
| COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin. | Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice.
Mederle K, Meurer M, Castrop H, Höcherl K. | 11/7/2015 |
| Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance. | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury.
Xiao J, Liong EC, Huang H, On Tse W, Lau KS, Pan J, Nanji AA, Fung ML, Xing F, Tipoe GL. | 10/3/2015 |
| Data suggest that multitarget FAAH/Cox blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase/cyclooxygenases (FAAH, Cox-1, and Cox-2) are overactive. | Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.
Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D., Free PMC Article | 08/29/2015 |
| In arteries from non-insulin-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 synthesis that evokes vasoconstrictor activity under the pathological condition. | Vasoconstrictor role of cyclooxygenase-1-mediated prostacyclin synthesis in non-insulin-dependent diabetic mice induced by high-fat diet and streptozotocin.
Zhu N, Liu B, Luo W, Zhang Y, Li H, Li S, Zhou Y. | 02/21/2015 |
| specific inhibition of mmu-miR-100-5p significantly enhanced expression of Il6, Ptgs1/2 and Tlr4 mRNA | MicroRNA-100-5p indirectly modulates the expression of Il6, Ptgs1/2 and Tlr4 mRNA in the mouse follicular dendritic cell-like cell line, FL-Y.
Aungier SR, Ohmori H, Clinton M, Mabbott NA., Free PMC Article | 02/14/2015 |
| COX1/2-derived prostanoids appear to play an important role in the TLR response, with elevated cytokine levels following COX1/2 inhibition or genetic deletion. | Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns.
Wright WR, Kirkby NS, Galloway-Phillipps NA, Reed DM, Paul-Clark MJ, Mitchell JA. | 08/9/2014 |
| Data suggest deletion of Cox1 delays ovarian follicle development prior to reproductive maturation of mutant mouse strain (Wv); inhibition of Cox1 (but not Cox2) may prolong ovarian follicle lifespan and delay the onset of premature ovarian failure. | Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.
Smith ER, Yang WL, Yeasky T, Smedberg J, Cai KQ, Xu XX., Free PMC Article | 05/31/2014 |