| Inefficient Sox9 upregulation and absence of Rspo1 repression lead to sex reversal in the B6.XYTIR mouse gonaddagger. | Inefficient Sox9 upregulation and absence of Rspo1 repression lead to sex reversal in the B6.XYTIR mouse gonad†.
Cao J, El Mansouri F, Reynoso S, Liu Z, Zhu J, Taketo T., | 07/8/2024 |
| Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos. | Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.
Shinozuka T, Aoki M, Hatakeyama Y, Sasai N, Okamoto H, Takada S. | 04/4/2024 |
| Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/beta-catenin pathway. | Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/β-catenin pathway.
Su X, Zhou G, Tian M, Wu S, Wang Y. | 10/16/2021 |
| R-spondin substitutes for neuronal input for taste cell regeneration in adult mice. | R-spondin substitutes for neuronal input for taste cell regeneration in adult mice.
Lin X, Lu C, Ohmoto M, Choma K, Margolskee RF, Matsumoto I, Jiang P., Free PMC Article | 05/8/2021 |
| Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKalpha-SREBP2 pathway. | Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
Liu S, Gao Y, Zhang L, Yin Y, Zhang W., Free PMC Article | 05/1/2021 |
| A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/beta-catenin signaling. | A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
Geng A, Wu T, Cai C, Song W, Wang J, Yu QC, Zeng YA., Free PMC Article | 02/13/2021 |
| Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland. | Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland.
Cai C, Geng A, Wang M, Yang L, Yu QC, Zeng YA. | 08/15/2020 |
| the Rspo3-Lgr5 axis simultaneously regulates both antimicrobial defence and mucosal regeneration | R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Sigal M, Reinés MDM, Müllerke S, Fischer C, Kapalczynska M, Berger H, Bakker ERM, Mollenkopf HJ, Rothenberg ME, Wiedenmann B, Sauer S, Meyer TF. | 11/30/2019 |
| blocking Rspo-Lgr4 signaling overcame Lewis lung carcinoma (LLC) resistance to anti-PD-1 therapy and improved the efficacy of PD-1 immunotherapy against B16F10 melanoma, indicating vital roles of Rspo-Lgr4 in host antitumor immunity and a potential therapeutic target in cancer immunotherapy. | Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization.
Tan B, Shi X, Zhang J, Qin J, Zhang N, Ren H, Qian M, Siwko S, Carmon K, Liu Q, Han H, Du B, Liu M. | 09/21/2019 |
| reciprocal control of antagonistic Wnt signaling pathways by Rspo1 in muscle stem cell progeny is a key step ensuring normal tissue architecture restoration following acute damage. | R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways.
Lacour F, Vezin E, Bentzinger CF, Sincennes MC, Giordani L, Ferry A, Mitchell R, Patel K, Rudnicki MA, Chaboissier MC, Chassot AA, Le Grand F., Free PMC Article | 12/2/2017 |
| In Rspo1 knock-out mice during pregnancy, a stronger expression of mesenchymal markers was observed, without modifications to the structure of mammary epithelial tissue. Mammary epithelial cell immunohistochemical analysis revealed a persistence of virgin markers, which signify a delay in cell differentiation. | Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.
Chadi S, Polyte J, Lefevre L, Castille J, Ehanno A, Laubier J, Jaffrézic F, Le Provost F., Free PMC Article | 09/2/2017 |
| RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration. | The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS. | 06/3/2017 |
| Rspo1 and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt/beta-catenin signaling for bone formation. | Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation.
Shi GX, Zheng XF, Zhu C, Li B, Wang YR, Jiang SD, Jiang LS., Free PMC Article | 04/29/2017 |
| We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT response and mammary cell expansion | RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.
Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R., Free PMC Article | 06/4/2016 |
| R-spondin 1/dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis | R-spondin 1/dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis.
Caruso M, Ferranti F, Corano Scheri K, Dobrowolny G, Ciccarone F, Grammatico P, Catizone A, Ricci G., Free PMC Article | 01/23/2016 |
| The ascl2 is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt/R-spondin can activate this regulatory loop. | Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.
Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H. | 12/19/2015 |
| RSPO1, WNT4, and beta-catenin have roles in the signaling pathway during ovarian differentiation in mice. | R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiation.
Chassot AA, Gillot I, Chaboissier MC. | 11/28/2015 |
| Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary | Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
Maatouk DM, Mork L, Chassot AA, Chaboissier MC, Capel B., Free PMC Article | 06/8/2015 |
| Rspo1 is required for ovarian differentiation by activation of the WNT/CTNNB1 signalling pathway | Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC. | 06/8/2015 |
| Rspo1 is involved in the progenitor cells proliferation of the coelomic epithelium of the undifferentiated gonad of the mouse embryo | WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.
Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC. | 06/8/2015 |
| ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain. | Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P., Free PMC Article | 04/4/2015 |
| overexpressed in culture-activated hepatic stellate cells | R-spondin1 arguments hepatic fibrogenesis in vivo and in vitro.
Xinguang Y, Huixing Y, Xiaowei W, Xiaojun W, Linghua Y. | 02/28/2015 |
| R-spondin1 (Rspo1) as a novel hormonal mediator in the mammary gland | R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal.
Cai C, Yu QC, Jiang W, Liu W, Song W, Yu H, Zhang L, Yang Y, Zeng YA., Free PMC Article | 12/20/2014 |
| Findings indicate that R-spondin1 (Rspo1) is a negative regulator of beta-cell neogenesis and suggest that Rspo1 may serve as a therapeutic target for the preservation or restoration of functional [beta]-cells in diabetes. | R-spondin1 deficiency enhances β-Cell neogenesis in a murine model of diabetes.
Chahal JK, Wong VS, Chaboissier MC, Brubaker PL. | 08/16/2014 |
| R-Spondin 1 is upregulated by mechanical signals and secreted. R-Spondin 1 promotes bone formation in three mouse models of osteoporosis. | R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis.
Wang H, Brennan TA, Russell E, Kim JH, Egan KP, Chen Q, Israelite C, Schultz DC, Johnson FB, Pignolo RJ., Free PMC Article | 07/19/2014 |