| Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1alpha Hyperactivation. | Prostaglandin E(2)-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation.
Wang W, Qin X, Lin L, Wu J, Sun X, Zhao Y, Ju Y, Zhao Z, Ren L, Pang X, Guan Y, Zhang Y. | 04/30/2022 |
| Adipocyte-derived PGE2 is required for intermittent fasting-induced Treg proliferation and improvement of insulin sensitivity. | Adipocyte-derived PGE2 is required for intermittent fasting-induced Treg proliferation and improvement of insulin sensitivity.
Wang C, Zhang X, Luo L, Luo Y, Yang X, Ding X, Wang L, Le H, Feldman LER, Men X, Yan C, Huang W, Feng Y, Liu F, Yang XO, Liu M., Free PMC Article | 04/16/2022 |
| Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. | Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker KA. | 03/12/2022 |
| Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation. | Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation.
Li YH, Zhu D, Yang T, Cheng L, Sun J, Tan L. | 10/9/2021 |
| Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance. | Prostaglandin E(2)-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.
Inazumi T, Yamada K, Shirata N, Sato H, Taketomi Y, Morita K, Hohjoh H, Tsuchiya S, Oniki K, Watanabe T, Sasaki Y, Oike Y, Ogata Y, Saruwatari J, Murakami M, Sugimoto Y. | 09/25/2021 |
| E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis. | E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
Patankar JV, Müller TM, Kantham S, Acera MG, Mascia F, Scheibe K, Mahapatro M, Heichler C, Yu Y, Li W, Ruder B, Günther C, Leppkes M, Mathew MJ, Wirtz S, Neufert C, Kühl AA, Paquette J, Jacobson K, Atreya R, Zundler S, Neurath MF, Young RN, Becker C. | 09/25/2021 |
| Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling. | Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling.
Ying F, Liu H, Ching Tang EH, Lakhani I, Liu N, Xia Z, Liu S. | 09/11/2021 |
| Epithelial EP4 plays an essential role in maintaining homeostasis in colon. | Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
Matsumoto Y, Nakanishi Y, Yoshioka T, Yamaga Y, Masuda T, Fukunaga Y, Sono M, Yoshikawa T, Nagao M, Araki O, Ogawa S, Goto N, Hiramatsu Y, Breyer RM, Fukuda A, Seno H., Free PMC Article | 11/21/2020 |
| EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes. | EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes.
Yasui-Kato M, Patlada S, Yokode M, Kamei K, Minami M., Free PMC Article | 10/3/2020 |
| Studied the role of prostaglandin E receptor 4 (EP4) in pathological vascular remodeling; found EP4 is critical for vascular homeostasis; demonstrated EP4 knockout exacerbates AngII-induced aortic dissection thru inflammation and increased blood pressure. | VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure.
Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y., Free PMC Article | 03/28/2020 |
| this study shows that T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation in psoriasis | T cell-intrinsic prostaglandin E(2)-EP2/EP4 signaling is critical in pathogenic T(H)17 cell-driven inflammation.
Lee J, Aoki T, Thumkeo D, Siriwach R, Yao C, Narumiya S., Free PMC Article | 02/22/2020 |
| Role of prostaglandin E2 receptor 4 in the modulation of apoptosis and mitophagy during ischemia/reperfusion injury in the kidney. | Role of prostaglandin E2 receptor 4 in the modulation of apoptosis and mitophagy during ischemia/reperfusion injury in the kidney.
Ding C, Han F, Xiang H, Wang Y, Dou M, Xia X, Li Y, Zheng J, Ding X, Xue W, Tian P. | 02/8/2020 |
| EP4 activated PI3K and then induced Ca(2+) influx from the extracellular space through Orai1. | Prostaglandin E(2) receptor EP4 regulates cell migration through Orai1.
Osawa K, Umemura M, Nakakaji R, Tanaka R, Islam RM, Nagasako A, Fujita T, Yokoyama U, Koizumi T, Mitsudo K, Ishikawa Y., Free PMC Article | 01/18/2020 |
| EPRAP regulates gluconeogenesis in hepatocytes and is associated with hyperglycemia in diabetic mice. | EP(4) receptor-associated protein regulates gluconeogenesis in the liver and is associated with hyperglycemia in diabetic mice.
Higuchi S, Fujikawa R, Nakatsuji M, Yasui M, Ikedo T, Nagata M, Mishima K, Irie K, Matsumoto M, Yokode M, Minami M. | 12/21/2019 |
| PGE2 regulates metabolism of hepatocytes mainly through EP4 receptor. | Application of a dye-based mitochondrion-thermometry to determine the receptor downstream of prostaglandin E(2) involved in the regulation of hepatocyte metabolism.
Shen L, Xie TR, Yang RZ, Chen Y, Kang JS., Free PMC Article | 10/26/2019 |
| CD4(+) T effector cells either deficient in prostaglandin E synthase (mPGES-1) or the prostaglandin E2 alpha (PGE2) prostaglandin EP4 receptor (receptor EP4) are less colitogenic. | mPGES-1-Mediated Production of PGE(2) and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.
Maseda D, Banerjee A, Johnson EM, Washington MK, Kim H, Lau KS, Crofford LJ., Free PMC Article | 10/26/2019 |
| Removal of the IP receptors unmasks a protective role of mPGES-1-derived PGE2 in limiting injury-induced vascular hyperplasia. EP4, in the endothelial compartment, is essential to promote reendothelialization and restrain neointimal formation after injury. | Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE(2) (Prostaglandin E(2)) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.
Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M., Free PMC Article | 07/13/2019 |
| Overexpression of EP4 improves cardiac function post myocardial infarction. | Overexpression of prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction.
Bryson TD, Gu X, Khalil RM, Khan S, Zhu L, Xu J, Peterson E, Yang XP, Harding P., Free PMC Article | 06/29/2019 |
| Study reports that mPGES-1 protects against acute myocardial ischemia-reperfusion (I/R) injury in mice and this is attributed to its critical role in preserving microcirculation and limiting inflammation in I/R. The cardioprotective effect of mPGES-1 is partially mediated through PGE2 action on the endothelial PGE receptor-4. | The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury.
Zhu L, Xu C, Huo X, Hao H, Wan Q, Chen H, Zhang X, Breyer RM, Huang Y, Cao X, Liu DP, FitzGerald GA, Wang M., Free PMC Article | 06/15/2019 |
| Our data suggest that deletion of EP4 in S100a4-lineage cells inhibits range of motion-limiting scar tissue without further compromising mechanical properties. | Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing.
Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE., Free PMC Article | 03/16/2019 |
| EP4 enhancement aggravated imbalanced mesangial cell proliferation stimulated by TGFbeta1 and GS of mice treated with 5/6 nephrectomy through the Smad and mitogenactivated protein kinase pathways. | EP4 knockdown alleviates glomerulosclerosis through Smad and MAPK pathways in mesangial cells.
Cao Y, Pan T, Chen X, Wu J, Guo N, Wang B. | 02/2/2019 |
| EP4 is a novel regulator of bile acid synthesis, and its activation protects against hypercholesterolemia. | EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia.
Ying F, Cai Y, Wong HK, Chen XY, Huang IB, Vanhoutte PM, Xia Z, Xu A, Tang EHC. | 12/1/2018 |
| Paricalcitol also attenuated the infiltration of inflammatory cells and production of proinflammatory cytokines after IR injury. EP4 antagonist abolished these antioxidant, anti-inflammatory, and antiapoptotic effects. The EP4 plays a pivotal role in the protective effects of paricalcitol in renal IR injury. | Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E(2) Receptor EP4 Pathway.
Hong YA, Yang KJ, Jung SY, Park KC, Choi H, Oh JM, Lee SJ, Chang YK, Park CW, Yang CW, Kim SY, Hwang HS., Free PMC Article | 02/24/2018 |
| These results demonstrate a novel role for prostaglandin receptor EP4 in the mediation of barrier-enhancing and anti-inflammatory effects caused by oxidized phospholipids. | Prostaglandin E receptor-4 receptor mediates endothelial barrier-enhancing and anti-inflammatory effects of oxidized phospholipids.
Oskolkova O, Gawlak G, Tian Y, Ke Y, Sarich N, Son S, Andreasson K, Bochkov VN, Birukova AA, Birukov KG., Free PMC Article | 10/14/2017 |
| The deletion of EP4 increases mitochondrial biogenesis and oxidative capacity in WAT, and fat mass loss ensues in mice. | Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue.
Ying F, Cai Y, Cai Y, Wang Y, Tang EHC. | 10/14/2017 |