| Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function. | Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function.
Fabiano M, Oikawa N, Kerksiek A, Furukawa JI, Yagi H, Kato K, Schweizer U, Annaert W, Kang J, Shen J, Lütjohann D, Walter J., Free PMC Article | 07/2/2024 |
| Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation. | Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation.
Yoo SS, Lee DW, Ham HJ, Yeo IJ, Chang JY, Yun J, Son DJ, Han SB, Hong JT., Free PMC Article | 03/4/2024 |
| Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes. | Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes.
Si Y, Chen J, Shen Y, Kubra S, Mei B, Qin ZS, Pan B, Meng B. | 08/10/2023 |
| Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury. | Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury.
Ma L, Liao L, Zhou N, Tao H, Zhou H, Tan Y, Chen W, Cao F, Chen X., Free PMC Article | 03/21/2023 |
| Chronic seizures induce sex-specific cognitive deficits with loss of presenilin 2 function. | Chronic seizures induce sex-specific cognitive deficits with loss of presenilin 2 function.
Knox KM, Beckman M, Smith CL, Jayadev S, Barker-Haliski M. | 02/4/2023 |
| Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBalpha. | Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα.
Nam H, Lee Y, Kim B, Lee JW, Hwang S, An HK, Chung KM, Park Y, Hong J, Kim K, Kim EK, Choe HK, Yu SW., Free PMC Article | 07/23/2022 |
| Exercise Reverses Amyloid beta-Peptide-Mediated Cognitive Deficits in Alzheimer's Disease Mice Expressing Mutant Presenilin-2. | Exercise Reverses Amyloid β-Peptide-Mediated Cognitive Deficits in Alzheimer's Disease Mice Expressing Mutant Presenilin-2.
Hwang DJ, Choi DH, Kwon KC, Kim EH, Kim TK, Koo JH, Cho JY. | 07/16/2022 |
| Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling. | Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling.
Bi HR, Zhou CH, Zhang YZ, Cai XD, Ji MH, Yang JJ, Chen GQ, Hu YM., Free PMC Article | 01/1/2022 |
| Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease. | Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease.
Rossi A, Galla L, Gomiero C, Zentilin L, Giacca M, Giorgio V, Calì T, Pozzan T, Greotti E, Pizzo P., Free PMC Article | 10/16/2021 |
| Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition. | Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.
Beckman M, Knox K, Koneval Z, Smith C, Jayadev S, Barker-Haliski M., Free PMC Article | 01/9/2021 |
| PS1- and PS2-dependent substrate processing in murine cells lacking presenilins (PSs) or stably re-expressing human PS1 or PS2 in an endogenous PS-null (PSdKO) background, were studied. | Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
Stanga S, Vrancx C, Tasiaux B, Marinangeli C, Karlström H, Kienlen-Campard P., Free PMC Article | 04/27/2019 |
| Study uncovers a role of PS in presynaptic mechanisms, through APP cleavage and regulation of Syt7, that highlights aberrant synaptic vesicle processing as a possible new pathway in Alzheimer's disease. | Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.
Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U, Mulle C., Free PMC Article | 04/20/2019 |
| The altered expressions of hippocampal microRNAs were associated to the imbalance between neurotoxic and neuroprotective functions and seemed to affect neurodegeneration in PSEN1/PSEN2 double knockout mice more severely than in wild-type mice. | MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice.
Ham S, Kim TK, Lee S, Tang YP, Im HI. | 02/9/2019 |
| These observations illustrate a novel PS2-dependent means of modulating LPS-mediated immune responses and identify a functional distinction between PS1 and PS2 in innate immunity. | Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.
Agrawal V, Sawhney N, Hickey E, McCarthy JV. | 12/23/2017 |
| Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline | Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.
Fontana R, Agostini M, Murana E, Mahmud M, Scremin E, Rubega M, Sparacino G, Vassanelli S, Fasolato C. | 10/7/2017 |
| Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2). | Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.
Filadi R, Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P. | 09/23/2017 |
| Study shows that the binding of HSF-1, Cdx1, Ets-1 and Sp1 to Presenilin 1 promoter and that of Nkx2.2, HFH-2, Cdx1 and NF-kappaB to Presenilin 2 promoter regulate their differential expression during brain development. | Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex.
Kumar A, Thakur MK. | 06/24/2017 |
| ARF4 is required for Presenilin basal body localization, Notch signaling, and subsequent epidermal differentiation. | A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.
Ezratty EJ, Pasolli HA, Fuchs E., Free PMC Article | 06/3/2017 |
| Results suggest that mutation of PS2 can lead to NF-kappaB mediate amyloidogensis, and this effect can be amplified by the absence of estrogen. | Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-κB dependent beta-secretase activation in presenilin 2 mutant mice.
Hwang CJ, Park MH, Choi MK, Choi JS, Oh KW, Hwang DY, Han SB, Hong JT. | 01/14/2017 |
| Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 and PS2 during cerebral cortical development | Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development.
Kumar A, Thakur MK. | 07/16/2016 |
| This study presents novel evidence for the differential expression of PS proteins in a nongenetic model for aging, resulting in an overall increase of the PS2 to PS1 ratio. | Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.
Kaja S, Sumien N, Shah VV, Puthawala I, Maynard AN, Khullar N, Payne AJ, Forster MJ, Koulen P., Free PMC Article | 05/21/2016 |
| The loss of PS2 could have a critical role in lung tumor development through the upregulation of iPLA2 activity by reducing gamma-secretase. | Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.
Yun HM, Park MH, Kim DH, Ahn YJ, Park KR, Kim TM, Yun NY, Jung YS, Hwang DY, Yoon DY, Han SB, Hong JT., Free PMC Article | 05/2/2015 |
| One mechanism by which PS2 works to reign in proinflammatory microglial behavior and PS2 dysfunction or deficiency could result in unchecked proinflammatory activation. contributing to neurodegeneration. | Presenilin 2 influences miR146 level and activity in microglia.
Jayadev S, Case A, Alajajian B, Eastman AJ, Möller T, Garden GA., Free PMC Article | 05/17/2014 |
| At the transcriptional level, Psen1/2 removal induced cyclic AMP response element-binding protein (CREB)/CREB-binding protein binding. | Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.
Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS., Free PMC Article | 02/15/2014 |
| Upregulation of PS1/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease. | Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.
Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC., Free PMC Article | 02/7/2014 |