| PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance. | PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
de Castro Moreira AR, Trarbach E, Bueno CBF, Monteiro ALS, Grande IPP, Padula M, Maciel GAR, Glezer A. | 06/22/2023 |
| [Prolactin and its receptor: From animal models to pituitary pathophysiology]. | [Prolactin and its receptor: From animal models to pituitary pathophysiology].
Begon E, Bernard V. | 03/2/2023 |
| Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring. | Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
Gauthier MF, de Andrade AA, Fisch J, Feistauer V, Morás AM, Reinhardt LS, de Moura AC, Moura DJ, de Almeida S, Guedes RP, Giovenardi M. | 03/5/2022 |
| The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro. | The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
Yuzhen C, Zheng F. | 03/5/2022 |
| Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice. | Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
Ramirez-Hernandez G, Adan-Castro E, Diaz-Lezama N, Ruiz-Herrera X, Martinez de la Escalera G, Macotela Y, Clapp C., Free PMC Article | 12/11/2021 |
| Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. | Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
Georgescu T, Ladyman SR, Brown RSE, Grattan DR. | 10/30/2021 |
| The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. | The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
Chen Y, Moutal A, Navratilova E, Kopruszinski C, Yue X, Ikegami M, Chow M, Kanazawa I, Bellampalli SS, Xie J, Patwardhan A, Rice K, Fields H, Akopian A, Neugebauer V, Dodick D, Khanna R, Porreca F., Free PMC Article | 07/17/2021 |
| Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling. | Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
Paige C, Barba-Escobedo PA, Mecklenburg J, Patil M, Goffin V, Grattan DR, Dussor G, Akopian AN, Price TJ., Free PMC Article | 01/23/2021 |
| Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. | Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
Tian RH, Bai Y, Li JY, Guo KM. | 10/24/2020 |
| Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent. | Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
Patil M, Hovhannisyan AH, Wangzhou A, Mecklenburg J, Koek W, Goffin V, Grattan D, Boehm U, Dussor G, Price TJ, Akopian AN., Free PMC Article | 10/24/2020 |
| Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy. | Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy.
Augustine RA, Knowles PJ, Khant Aung Z, Grattan DR, Ladyman SR. | 10/24/2020 |
| Data dhow that prolactin receptor (PRLR) signaling target genes promote a state of increased cellular metabolism and/or proliferation. | Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.
Pepin ME, Bickerton HH, Bethea M, Hunter CS, Wende AR, Banerjee RR., Free PMC Article | 12/21/2019 |
| miR-142-3p regulates milk synthesis and the structure of murine mammary glands via PRLR-mediated multiple signaling pathways. | miR-142-3p Regulates Milk Synthesis and Structure of Murine Mammary Glands via PRLR-Mediated Multiple Signaling Pathways.
Tian L, Zhang L, Cui Y, Li H, Xie X, Li Y, Wang C. | 10/26/2019 |
| Study shows prolactin receptors in Rip-cre cells, but not in AgRP neurones, are involved in energy homeostasis. Results indicate that Rip-Cre neurones in the arcuate nucleus are responsive to prolactin and may play a role in the orexigenic effects of prolactin, whereas prolactin does not directly affect Agrp neurones. | Prolactin receptors in Rip-cre cells, but not in AgRP neurones, are involved in energy homeostasis.
Ladyman SR, MacLeod MA, Khant Aung Z, Knowles P, Phillipps HR, Brown RSE, Grattan DR. | 06/9/2018 |
| The estrogen-responsive pituitary hormone prolactin (PRL), through specific PRL receptor (PRLR), down-regulates hepatic triglyceride (TG) accumulation. | Ablation of prolactin receptor increases hepatic triglyceride accumulation.
Shao S, Yao Z, Lu J, Song Y, He Z, Yu C, Zhou X, Zhao L, Zhao J, Gao L. | 05/5/2018 |
| Truncating mutations of Prlr promote tumor growth in a model of human ERalpha+ breast cancer. | Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas.
Griffith OL, Chan SR, Griffith M, Krysiak K, Skidmore ZL, Hundal J, Allen JA, Arthur CD, Runci D, Bugatti M, Miceli AP, Schmidt H, Trani L, Kanchi KL, Miller CA, Larson DE, Fulton RS, Vermi W, Wilson RK, Schreiber RD, Mardis ER., Free PMC Article | 11/18/2017 |
| This study demonstrated that there are at least two functional subpopulations of dopamine neurons in the arcuate nucleus, with approximately 50% of these neurons expressing GABA. | Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.
Brown RS, Kokay IC, Phillipps HR, Yip SH, Gustafson P, Wyatt A, Larsen CM, Knowles P, Ladyman SR, LeTissier P, Grattan DR., Free PMC Article | 08/19/2017 |
| MafB deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy. | Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells.
Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK., Free PMC Article | 06/10/2017 |
| Of the four placenta-specific, Prl-related hormones that have been shown to interact with the Prlr, their gene expression localizes to different endocrine cell types | Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis.
Rawn SM, Huang C, Hughes M, Shaykhutdinov R, Vogel HJ, Cross JC., Free PMC Article | 06/28/2016 |
| Prolactin transport into mouse brain is independent of prolactin receptor. | Prolactin transport into mouse brain is independent of prolactin receptor.
Brown RS, Wyatt AK, Herbison RE, Knowles PJ, Ladyman SR, Binart N, Banks WA, Grattan DR. | 06/28/2016 |
| Prolactin receptor was upregulated in proximal kidney tubule cells of mice with cardiac disease. | Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice.
Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, Yamamoto T, Narita I. | 05/14/2016 |
| This study showed in knockout mice showed no effect of PRL and PRL-R gene ablation on heat and cold hyperalgesia in male mice, while heat hyperlgesia were reduced 3-72 h post-surgery in female PRL and PRL-R knockout mice | Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice.
Patil MJ, Green DP, Henry MA, Akopian AN., Free PMC Article | 06/21/2014 |
| The in utero environment of the Prlr(+/-) mother confers long-term changes in the pancreatic islets of her offspring such that when the offspring themselves became pregnant, they cannot adapt to the increased insulin demands of their own pregnancy. | Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive β-cell responses during pregnancy.
Huang C., Free PMC Article | 08/31/2013 |
| results provide direct genetic evidence that PRLR affects energy balance and metabolic adaptation in rodents via effects on brown adipose tissue differentiation and function | Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity.
Auffret J, Viengchareun S, Carré N, Denis RG, Magnan C, Marie PY, Muscat A, Fève B, Lombès M, Binart N. | 12/29/2012 |
| Germline knockout of prolactin or its receptor has failed to reveal a key role for prolactin signaling in mouse prostate physiology. | Prolactin regulation of the prostate gland: a female player in a male game.
Goffin V, Hoang DT, Bogorad RL, Nevalainen MT., Free PMC Article | 08/18/2012 |